CAS: 55804-65-4; 11-Oxo-2,3,5,6,7,11-Hexahydro-1H-Pyrano[2,3-F]Pyrido[3,2,1-Ij]Quinoline-10-Carboxylic Acid

相似化合物

142730-52-7 55804-66-5 55804-68-7

上下游产品

coumarin 343 methyl ester 8-hydroxyjulolidine 8-methoxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline 9-formyl-8-hydroxyjulolidineacetophenone H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carboxylic acid 4-(2-bromo-2-methyl-propionyloxy)-phenyl ester10-oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carboxylic acid 4-(2-bromo-2-methyl-propionyloxy)-phenyl ester H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carboxylic acid pentafluorophenyl ester10-oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carboxylic acid pentafluorophenyl ester 28H31BN2O5C28H31BN2O5

📜香豆素 314置于盐酸,氨体系中,用 水 作为反应溶剂,化学反应 20.0H,以59%的收率获得产物香豆素 343
参考文献:基于拮抗剂net-C343荧光变化的便捷类维生素a X受体结合测定
标题:基于拮抗剂net-C343荧光变化的便捷类维生素a X受体结合测定
摘要:类维生素a X受体(rxr)调节剂(类维生素a)被认为具有治疗多种疾病的潜力,例如阿尔茨海默氏病和帕金森氏病.为了克服现有筛选方法的各种缺点,我们先前开发了使用荧光rxr配体cu-6Pmn(4)的rxr结合测定.但是,该配体不仅在配体结合域(lbd)上结合,而且在hrxrα的二聚体-二聚体界面上结合.这里,我们提出一个新的荧光rxr拮抗剂6-[ñ乙基ñ-(5-异丁氧基-4-异丙基-2-(11-氧代-2,3,6,7-四氢-1-ħ,5 ħ,11 H-吡喃基[2,3-F]吡啶基[3,2,1-Ij]喹啉-10-甲酰氨基)苯基)氨基]烟酸(net-C343,7),其发射只有当结合于rxr-Lbd强的荧光.它使我们能够执行快速,简单且无害的结合测定,不需要结合/自由分离,而使用标准的酶标仪.将获得的已知化合物的k I值与使用标准[3 H] 9顺式-视黄酸测定法获得的k I值相关.
DOI:10.1021/acs.Jmedchem.0C01883

专利信息

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-8263755-B2
优先权日:2006-11-20
标题:Synthesis of compounds useful as modulators of amyloid-beta production
发明人：FINDEIS MARK A
权利人:FINDEIS MARK A; SATORI PHARMACEUTICALS INC
摘要:As described herein, the present invention provides methods for preparing compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.

专利号:US-8268936-B2
优先权日:2005-01-04
标题:Synthesis of hybrid block copolymers and uses thereof
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.

专利号:US-2012196989-A1
优先权日:2005-02-11
标题:Synthesis of homopolymers and block copolymers
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to homopolymers and block copolymers and methods of preparing the same.

专利号:US-11959137-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

专利号:US-2024376536-A1
优先权日:2015-09-28
标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis