CAS: 548-57-2; Lucanthone Hydrochloride

该化合物是一种二氧化二氮衍生物,在生化和药理研究中具有显著应用性,可用作托波异构体酶II抑制剂,并已研究过其潜在的抗菌素和抗寄生素特性,特别是防止血吸虫病.该化合物显示出对DNA具有内在联系性,干扰核酸合成和复制.其盐分形式会增加溶解性,促进体外和体外实验使用.Lucanthone Hitrodrodroide因其在研究DNA交互剂方面的功能和实用性而备受重视.研究人员优先考虑该物质在针对甲状腺酶抑制物的实验中的可复制性及其在探索乳气抑制物战略中的作用.由于其生物活性,需要妥善处理.

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      专利号:US-9409879-B2
      优先权日:2011-03-29
      标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
      发明人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA
      权利人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA; CENTRE NAT RECH SCIENT
      摘要:Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.

      专利号:US-12145139-B2
      优先权日:2016-02-09
      标题 :Manganese based complexes and uses thereof for homogeneous catalysis
      发明人:MILSTEIN DAVID; NERUSH ALEX; VOGT MATTHIAS; MUKHERJEE ARUP; ESPINOSA-JALAPA NOEL ANGEL; CHAKRABORTY SUBRATA
      权利人:YEDA RES & DEV; NERUSH ARKADI
      摘要:The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C—C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

      专利号:CN-105061515-A
      优先权日:2015-08-08
      标题 :Synthesis of a phosphorescent iridium complex and its use in fluorescent labeling of cercariae of Schistosoma japonicum

      专利号:US-2014121238-A1
      优先权日:2011-03-29
      标 题:Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents

      专利号:WO-2012131010-A1
      优先权日:2011-03-29
      标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents

      专利号:CN-103534238-A
      优先权日:2011-03-29
      标 题:Total synthesis of redox active 1, 4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistosomimetics

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      主要参考文献


      1: Fu W, Li X, Lu X, Zhang L, Li R, Zhang N, Liu S, Yang X, Wang Y, Zhao Y, Meng X, Zhu WG. A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells. Cell Death Dis. 2017 Oct 5;8(10):e3086. doi: 10.1038/cddis.2017.498.
      2: Laev SS, Salakhutdinov NF, Lavrik OI. Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1). Bioorg Med Chem. 2017 May 1;25(9):2531-2544. doi: 10.1016/j.bmc.2017.01.028. Epub 2017 Jan 21. Review. doi: 10.1080/15548627.2017.1280222. Epub 2017 Jan 24.
      4: Lima RT, Sousa D, Paiva AM, Palmeira A, Barbosa J, Pedro M, Pinto MM, Sousa E, Vasconcelos MH. Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells. Molecules. 2016 Oct 10;21(10). pii: E1343. doi: 10.1021/acs.jcim.6b00317. Epub 2016 Sep 1. doi: 10.1016/j.nano.2014.08.001. Epub 2014 Aug 13.

      合成参考文献


      摘要:National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program., JAN1986
      摘要:O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 1002
      摘要:
      摘要:Bases R et al; Cancer Research 37 (7): 2177-2181 (1977)
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