CAS: 52663-70-4; 2,2',3,3',4,5',6'-Heptachloro-1,1'-Biphenyl

该化合物是多氯联苯(PCB)家族的成员,该家族由以其环境持久性和潜在毒性而闻名的合成有机化学品组成.PCB 177的特点是其氯化芳香结构,有助于其稳定性和降解抗药性.该复合体通常具有低挥发性和高脂性,导致活生物体中的生物累积性和食物链中的潜在生物放大作用.多氯联苯,包括PC 177,已知会扰乱内分泌功能,并可能造成各种健康风险,包括致癌影响.它们还因其长期的环境半衰期而被归类为持久性有机污染物.PCB PC 177主要用于工业应用,如电气设备和热传输液,尽管由于环境和健康问题,许多国家已基本禁止或限制其生产.目前正在开展监测和补救工作,以解决环境中的多氯联苯遗留问题.

英文名称2,2',3,3',4,5',6'-Heptachloro-1,1'-Biphenyl
中文名称2,2',3,3',4,5',6'-七氯-1,1'-联苯
IUPAC名称1,2,4,5-tetrachloro-3-(2,3,4-trichlorophenyl)benzene
其它别名2,2',3,3',4',5,6-七氯联苯; 2,2',3,3',4,5',6'-Heptachlorobiphenyl
CAS编号52663-70-4
MFCD编号:MFCD01310483
FDA UNII编号:LEE72YP9XF
分子式:C12H3Cl7分子量:395.32
产品CID: 2499416
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: CXOYNJAHPUASHN-UHFFFAOYSA-N
1S/C12H3Cl7/c13-5-2-1-4(9(16)12(5)19)8-10(17)6(14)3-7(15)11(8)18/h1-3H
计算化学: 氢键受体数*氢键供体数0可旋转键数1

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

CAS号62720-28-9 2,3,4-trichloro... | CAS号32770-82-4 1,2,4,5-tetrach... | CAS号3481-20-7 2,3,5,6-四氯苯胺 | CAS号87-61-6 1,2,3-三氯苯

合成工艺路线路线简述

📜2,3,5,6-四氯苯胺,三氯苯置于亚硝酸异戊酯体系中,化学反应生成 2,2',3,3',4',5,6-七氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4