CAS: 51336-95-9; 2-Chloro-1-(3,4-Difluorophenyl)Ethanone

上下游产品

CAS号367-11-3 邻二氟苯 | CAS号79-04-9 氯乙酰氯 | CAS号220352-36-3 (1R,2S)-rel-2-(... | CAS号274693-27-5 替卡格雷 | CAS号1006376-61-9 (1R,2R)-2-(3,4-... | CAS号1006376-60-8 (ALPHAS)-ALPHA-... | CAS号1006376-62-0 (1R,2R)-2-(3,4-... | CAS号1006376-63-1 (S)-2-(3,4-二氟苯基)环氧乙烷 | CAS号175135-32-7 2-氨基-4-(3,4-二氟苯基)噻唑

1,2-二氟苯 以96%的收率获得产物
参考文献:Bercher H.; Ehlers D.; Grisk A.,Pharmazie,1976,31,No 6,351-354;
标题:Bercher H.; Ehlers D.; Grisk A.,Pharmazie,1976,31,No 6,351-354;

专利信息

专利号:EP-2644590-A1
优先权日:2012-03-30
标 题:Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-2018148745-A1
优先权日:2015-05-26
标题:Hemoprotein catalysts for improved enantioselective enzymatic synthesis of ticagrelor
发明人：ARNOLD FRANCIS H; RENATA HANS; MCINTOSH JOHN A; LEWIS RUSSELL D; KAN SEK BIK JENNIFER; HERNANDEZ KARI; COELHO PEDRO; ROZZELL DAVID; ZHANG CHEN
权利人:CALIFORNIA INST OF TECHN; PROVIVI INC
摘要:The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.

专利号:CN-111763662-A
优先权日:2019-11-29
标题 :Ketoreductase and its application in the synthesis of ticagrelor intermediates

专利号:CN-111763662-B
优先权日:2019-11-29
标题 :Ketoreductase and its application in the synthesis of ticagrelor intermediates

专利号:EP-2628721-A1
优先权日:2012-02-20
标题 :Synthesis of 2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

专利号:CN-118726287-A
优先权日:2024-07-01
标题:Short-chain dehydrogenase mutant and application thereof in synthesis of ticagrelor key chiral intermediate