CAS: 205526-39-2; (S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-2-(2,3-Dihydro-1H-Inden-2-yl)Acetic Acid

专利信息

专利号:WO-2023105497-A1
优先权日:2021-12-10
标题:Synthesis of glp-1 analogues
发明人：GODHA ATUL KASTURCHAND; NARAYANASWAMY SATHYA VANGANUR; BHAGYARAJ ARETI VENKATA; BAVADEKAR ASLAM JAHANGIR; LAKSHMANAPPA RUDRESH; NAGOOR SHEIKSYEDALI; MURUGAN RANJITHKUMAR; GADAKH AMOL VASANTRAO; SAMBASIVAM GANESH
权利人:ANTHEM BIOSCIENCES PVT LTD
摘要:The present invention provides a method of preparation of GLP-1 peptides by using different peptide fragments having amino acid sequences SEQ ID NO:1 (Fragment IG), SEQ ID NO:2 (Fragment SG), Fragment BG, SEQ ID NO:3, and SEQ ID NO:4 5 and combinations thereof. The method of preparation is environmentally benign, simple, straightforward, and efficient and provides the end product in high yield and purity. The purification method of the peptides is also described.

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:WO-2023279324-A1
优先权日:2021-07-08
标 题 :Method for synthesizing glp-1 analog
发明人：WANG WEI; HUANG JIACHENG; YIN CHUANLONG; TANG YANGMING
权利人:HYBIO PHARMACEUTICAL CO LTD
摘要:The present invention relates to the technical field of polypeptide synthesis, in particular to a method for synthesizing a GLP-1 analog. In the present invention, fragment 1 at positions 1-4 of an N terminus of a GLP-1 analog is firstly synthesized, and then amino acids as shown in SEQ ID NO: 2 and fragment 1 are sequentially coupled on a solid-phase carrier in a sequence from a C terminus to the N terminus to obtain a peptide resin which is cleaved to obtain a crude peptide. Liraglutide and semaglutide are synthesized using a specific synthesis strategy of the present invention, so that the purity and the yield are high, and the amount of the impurity Des-Thr5 is small. Moreover, in the present invention, the synthesis process is simple, and the method is suitable for large-scale production.

专利号:WO-2024156694-A1
优先权日:2023-01-24
标 题:Method for synthesizing polypeptides
发明人：GLAFFIG MARKUS; HENNIG RABEA; HANSEN ANNA METTE; FOMSGAARD JENS; PAWLAS JAN
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to a method for synthesizing a polypeptide based on solid phase peptide synthesis, the polypeptide comprising a backbone, the backbone comprising one amino acid moiety Δ selected from diamino alkanoic acids comprising from 3 up to 10 carbon atoms and one peptide side chain covalently attached to the amino acid moiety Δ, the amino acid moiety Δ being coupled to an amino acid moiety W of the backbone, the method comprising at least one reaction cycle comprising providing an amino acid building block, activating the amino acid building block in absence of a solid phase at a defined temperature and time period, and coupling the amino acid building block to the backbone.

专利号:CA-2614226-A1
优先权日:2005-07-06
标 题 :High yield synthesis methods for producing organic salts of strontium

专利号:AU-2006265491-A1
优先权日:2005-07-06
标 题:High yield synthesis methods for producing organic salts of strontium