专利号:US-9085538-B2 优先权日:2010-07-26 标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof 发明人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO 权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS 摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.
专利号:US-2005009055-A1 优先权日:2002-07-12 标 题 :System and method for examination of microarrays using scanning electron microscope 发明人:CICCOLELLA PAUL C; HOZBOR MARIA A 权利人:AFFYMETRIX INC 摘要:The present invention provides methods to detect biomolecules on a microarray using a scanning electron microscope. In one embodiment of the invention, errors in oligonucleotide synthesis during manufacturing of microarrays are detected by monitoring synthesis of control probes on the chips. In another embodiment, misalignment of features on the chip is determined. In yet another embodiment, the size, shape and edge definition of features on the chip is determined. In further embodiments, methods are provided for analyzing interactions between an oligonucleotide target and an oligonucleotide probe on a microarray and methods for testing conditions in a microarray manufacturing process.
专利号:US-9121110-B2 优先权日:2002-12-19 标 题 :Quasirandom structure and function guided synthesis methods 发明人:GOULIAEV ALEX HAAHR; HOLTMANN ANETTE; PEDERSEN HENRIK; FRANCH THOMAS 权利人:GOULIAEV ALEX HAAHR; HOLTMANN ANETTE; PEDERSEN HENRIK; FRANCH THOMAS; NUEVOLUTION AS 摘要:The present invention is directed to the synthesis of molecules guided by connector polynucleotides (CPNs) capable of hybridizing to complementary connector polynucleotides (CCPNs) harboring at least one functional entity comprising at least one reactive group. At least one of the CCPNs is capable of hybridizing to at least two CPNs. Each CPN will “callâ€? for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of reactive groups results in the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNsâ€? to at least one “acceptor CCPNâ€? with which the transferred functional entities were not associated prior to the transfer.
专利号:US-2004081985-A1 优先权日:2002-07-12 标题:Systems and method for examination of microarrays using scanning electron microscope 发明人:CICCOLELLA PAUL C; HOZBOR MARIA A 权利人:AFFYMETRIX INC 摘要:The present invention provides methods to detect biomolecules on a microarray using a scanning electron microscope. In one embodiment of the invention, errors in oligonucleotide synthesis during manufacturing of microarrays are detected by monitoring synthesis of control probes on the chips. In another embodiment, misalignment of features on the chip is determined. In yet another embodiment, the size, shape and edge definition of features on the chip is determined. In further embodiments, methods are provided for analyzing interactions between an oligonucleotide target and an oligonucleotide probe on a microarray and methods for testing conditions in a microarray manufacturing process.
专利号:US-2014051854-A1 优先权日:2010-07-26 标题 :Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
专利号:WO-2012013325-A1 优先权日:2010-07-26 标题 :Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
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