CAS: 1912-28-3; Methyl Ethanesulfonate

该化合物是有机合成和诱变研究中常用的一种烷基剂,其主要优点包括作为甲基制剂的高度活性,能够有效地将甲基组转移到DNA,蛋白质和其他分子的核循环病原点;甲基乙烷磺酸盐(MES)因其能够对分子结构进行精确的修改,使其在遗传研究和化学合成中有用而受到重视;化合物在极地有机溶剂中表现出良好的溶解性,便利其在实验室环境中的应用;由于其碳基特性,MES还被用于研究诱变机制和DNA修复过程;适当处理由于其潜在毒性至关重要.

结构式图片

相似化合物

1912-30-7 62-50-0 66-27-3

欧盟法规

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CAS号67-56-1 甲醇 | CAS号594-44-5 乙基磺酰氯 | CAS号594-45-6 乙基磺酸 | CAS号149-73-5 原甲酸三甲酯 | CAS号124-41-4 甲醇钠

合成工艺路线路线简述

  • 合成目标产物 Methyl Ethanesulfonate 主要起始原料 Ethanesulfonic Acid And Trimethoxymethane
  • (文献来源)合成步骤主要原料 Ethanesulfonic Acid 和 Trimethoxymethane
📜乙基磺酸,原甲酸三甲酯 反应 14.0H,以83%的收率获得2-(N-吗啉)乙烷磺酸
参考文献:Padmapriya,A. A.; Just,G.; Lewis,N. G.,Synthetic Communications,1985,Vol. 15,# 12,P. 1057-1062
标题:Padmapriya,A. A.; Just,G.; Lewis,N. G.,Synthetic Communications,1985,Vol. 15,# 12,P. 1057-1062

海关参考信息

专利信息


专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:US-2005009055-A1
优先权日:2002-07-12
标 题 :System and method for examination of microarrays using scanning electron microscope
发明人:CICCOLELLA PAUL C; HOZBOR MARIA A
权利人:AFFYMETRIX INC
摘要:The present invention provides methods to detect biomolecules on a microarray using a scanning electron microscope. In one embodiment of the invention, errors in oligonucleotide synthesis during manufacturing of microarrays are detected by monitoring synthesis of control probes on the chips. In another embodiment, misalignment of features on the chip is determined. In yet another embodiment, the size, shape and edge definition of features on the chip is determined. In further embodiments, methods are provided for analyzing interactions between an oligonucleotide target and an oligonucleotide probe on a microarray and methods for testing conditions in a microarray manufacturing process.

专利号:US-9121110-B2
优先权日:2002-12-19
标 题 :Quasirandom structure and function guided synthesis methods
发明人:GOULIAEV ALEX HAAHR; HOLTMANN ANETTE; PEDERSEN HENRIK; FRANCH THOMAS
权利人:GOULIAEV ALEX HAAHR; HOLTMANN ANETTE; PEDERSEN HENRIK; FRANCH THOMAS; NUEVOLUTION AS
摘要:The present invention is directed to the synthesis of molecules guided by connector polynucleotides (CPNs) capable of hybridizing to complementary connector polynucleotides (CCPNs) harboring at least one functional entity comprising at least one reactive group. At least one of the CCPNs is capable of hybridizing to at least two CPNs. Each CPN will “callâ€? for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of reactive groups results in the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNsâ€? to at least one “acceptor CCPNâ€? with which the transferred functional entities were not associated prior to the transfer.

专利号:US-2004081985-A1
优先权日:2002-07-12
标题:Systems and method for examination of microarrays using scanning electron microscope
发明人:CICCOLELLA PAUL C; HOZBOR MARIA A
权利人:AFFYMETRIX INC
摘要:The present invention provides methods to detect biomolecules on a microarray using a scanning electron microscope. In one embodiment of the invention, errors in oligonucleotide synthesis during manufacturing of microarrays are detected by monitoring synthesis of control probes on the chips. In another embodiment, misalignment of features on the chip is determined. In yet another embodiment, the size, shape and edge definition of features on the chip is determined. In further embodiments, methods are provided for analyzing interactions between an oligonucleotide target and an oligonucleotide probe on a microarray and methods for testing conditions in a microarray manufacturing process.

专利号:US-2014051854-A1
优先权日:2010-07-26
标题 :Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

专利号:WO-2012013325-A1
优先权日:2010-07-26
标题 :Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

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合成参考文献


参考文献:10.1007/978-3-030-79229-9_15
摘要:Rattan A, Sharma D, Bhardwaj S, Pujari M, Kapoor D, Bhardwaj R, Sharma A. Role of Salicylic Acid in Mitigation of Biotic Stress. 2021. In: Salicylic Acid - A Versatile Plant Growth Regulator.
参考文献:10.1007/s00344-023-10990-5
摘要:Shumaila, Ullah S, Nafees M. Biochar Application to Soil and Seed Pre-Soaking on Growth, Yield and Physiological Response of Solanum melongena L. Under Induced Abiotic Stresses. J Plant Growth Regul. 2023 May 08;42(11):6980–7003. doi: 10.1007/s00344-023-10990-5.
参考文献:10.1007/978-981-96-2339-6_5
摘要:Nandedkar K, Jha Z, Verulkar SB. Rice and Maize Haploids. 2025. In: Doubled Haploids: Technological Advances and Role In Crop Improvement.
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