CAS: 186296-23-1; (S)-N-(1-(4-Bromophenyl)Ethyl)Acetamide

该化合物是一种有机化合物,其特性为氨化功能组,该物质具有一种溴化芳香环,特别是半溴联苯组,有助于其化学特性和潜在的生物活动.附于氮原子的乙基组的存在表明它是一种二次粘合.该化合物的立体化学由能够影响其相互作用和再活动的一种(S)配置界定.一般而言,这种化合物可能具有多种特性,例如有机溶剂中的溶性,标准条件下的中度稳定性,制药或有机合成中的中间体的潜在应用.该溴亚基元素可增强该化合物的再活动性,并可能影响其红地特性,例如脂性以及与生物目标的亲近性.

英文名称(S)-N-(1-(4-Bromophenyl)Ethyl)Acetamide
中文名称(S)-N-(1-(4-溴苯基)乙基)乙酰胺
IUPAC名称(S)-N-(1-(4-bromophenyl)ethyl)acetamide
其它别名(S)-N-(1-(4-Bromophenyl)Ethyl)Acetamide; (S)-N-Acetyl-1-(4-Bromophenyl)Ethylamine; Acetamide, N-[(1S)-1-(4-Bromophenyl)Ethyl]-
CAS编号186296-23-1
MFCD编号:MFCD20926114
分子式:C10H12BrNO分子量:242.12
产品CID: 950262
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: DRRCKKJEBGEBGR-ZETCQYMHSA-N
InChI=1S/C10H12BrNO/c1-7(12-8(2)13)9-3-5-10(11)6-4-9/h3-7H,1-2H3,(H,12,13)/t7-/m0/s1
计算化学: 氢键受体数1.0氢键供体数1可旋转键数2

相似化合物

36283-44-0 36065-27-7 92520-16-6

MSDS等安全信息

上下游产品

(S)-(-)-1-(4-溴苯)乙胺 (S)-1-(4-Bromophenyl)Ethylamine 27298-97-1
4-溴-α-甲基苄胺 1-(4-Bromophenyl)Ethylamine 24358-62-1
N-[1-(4-溴苯基)乙烯基]乙酰胺 N-{1-(4-Bromophenyl)Vinyl}Acetamide 177750-12-8

合成工艺路线路线简述

合成目标产物 (S)-N-(1-(4-Bromophenyl)Ethyl)Acetamide 主要起始原料 N - (1 - (4' - Bromophenyl)Vinyl)Acetamide
(文献来源)合成步骤主要原料 N - (1 - (4' - Bromophenyl)Vinyl)Acetamide

📜(S)-N-(1-(4-Hydroxyphenyl)Ethyl)Acetamide置于n-溴代丁二酰亚胺(Nbs),Copper(I) Bromide体系中,用乙腈用作溶剂,化学反应 12.0H,反应生成(S)-N-乙酰-1-(4-溴苯基)乙胺
参考文献:Chemoenzymatic Synthesis Of Boron-Containing Chiral Amines And Amides
标题:Chemoenzymatic Synthesis Of Boron-Containing Chiral Amines And Amides
摘要:The First Application Of Lipases As Catalysts To Obtain Optically Active Boron-Containing Amines And Amides Is Described. We Studied Several Reaction Conditions To Achieve The Kinetic Resolution Of Boron-Containing Amines Via Enantioselective Acylation Mediated By Candida Antarctica Lipase B (Cal-B). Excellent Enantioselectivity (E>200) And High Enantiomeric Excess (Up To >99%) Of Both The Remaining Amines And Amides Were Obtained. (C) 2010 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetasy.2010.09.011