CAS: 175135-63-4; 2-(2,4-Difluorophenoxy)Pyridin-3-Amine

相似化合物

175135-62-3 175135-66-7 175135-64-5

上下游产品

CAS号175135-62-3 2-(2,4-二氟苯氧基)-3-硝基吡啶 | CAS号5470-18-8 2-氯-3-硝基吡啶 | CAS号367-27-1 2,4-二氟苯酚

📜2-(2,4-二氟苯氧基)-3-硝基吡啶置于sodium Dithionite,水体系中,用 四氢呋喃 用作溶剂,化学反应 2.5H,以80%的收率获得3-氨基-2-(2,4-二氟苯氧基)吡啶
参考文献:Synthesis Of N-[2-(2,4-Difluorophenoxy)Trifluoromethyl-3-Pyridyl]Sulfonamides And Their Inhibitory Activities Against Secretory Phospholipase A2
标题:Synthesis Of N-[2-(2,4-Difluorophenoxy)Trifluoromethyl-3-Pyridyl]Sulfonamides And Their Inhibitory Activities Against Secretory Phospholipase A2
摘要:N-[2-(2,4-二氟苯氧基)三氟甲基-3-吡啶基]磺酰胺衍生物3-6是通过3-吡啶胺与磺酰氯的反应制备的.这些化合物对分泌型磷脂酶a2(spla2)的抑制活性进行了研究,发现n-[2-(2,4-二氟苯氧基)-5-三氟甲基-3-吡啶基]-2-萘磺酰胺(5C)对spla2的抑制作用最强,其ic50值为90μm.
Doi:10.1248/cpb.59.1069

专利信息

专利号:US-2020087149-A1
优先权日:2015-07-22
标 题 :Method for the synthesis of nanofluids
发明人：TALAEI ZEINAB; RASHIDI ALIMORAD; AMROLLAHI BIYOUKI AZADEH; MAHJOUB ALLREZA; LOTFI ROGHAYYEH; RASHTCHI MARYAM
权利人:RES INSTITUTE OF PETROLEUM INDUSTRY
摘要:The present invention relates to a method for the synthesis of nanofluids including functionalization of carbon nanostructures through a new method comprising the addition of carbon nanostructures to water; ultrasonication of the solution; addition of persulfate salt and one or several metal hydroxides of the first column of the periodic table to the aqueous solution containing carbon nanostructure; re-exposing the solution to ultrasonic waves; and then, the separation of the functionalized carbon nanostructures from the solution and washing the carbon nanostructures with water to neutralize them and mixing the nanoparticles obtained from the previous step with the fluid. By presenting a new method for the synthesis of the functionalized carbon nanostructures with specific amount of functional groups and their application in the synthesis of nanofluids, an increase in the stability and thermal conductivity of nanofluids takes place.

专利号:US-6717007-B1
优先权日:1999-09-16
标 题:Regiospecific synthesis of phosphonous acids
发明人：DUBEY SUSHIL KUMAR; RAJGOPAL VENKAT; SINGH ANIL VIR; LAHIRI SASWATA; WANI MUKESH JAGANNATH
权利人:LUPIN LTD
摘要:An improved regiospecific synthesis of organic phosphonous acids, comprising of hydrophosphorylation of an olefin with hydrophosphorous acid in the presence of an inorganic persulfate, which acts as a source of free radicals at a pH ranging from 4.5 to 7.0, in which the orientation of addition is anti-Markonikoff. The process enables production of organic phosphonous acids at lower temperature and atmospheric pressure under milder pH conditions for better regioselectivity in hydrophosphorylation and obtain the phosphonous acid with good yield and purity following simple isolation procedure. Phosphonous acids obtained by the process are commercially valuable as effective detergents and wetting agents, lubricants and lubricant additives, plasticizers for plastics and resins, corrosion inhibitors, chemicals including insecticides and pesticides, cobalt extractants and as key intermediates for preparation of commercially important angiotensin converting enzyme (ACE) inhibitors.

专利号:EP-0058173-B1
优先权日:1980-08-26
标 题:Process for the synthesis of aryloxy derivatives
摘要:Process for the synthesis of compounds of formula I (FORMULA) wherein O, is a substituted or unsubstituted aryl or heteroaryl group and U and V may be chosen from a range of substituents including hydrogen, halogen, alkyl and alkoxy; the process comprising reacting a sulfate ester of formula II, wherein Q is a cation, with a compound of formula III, wherein L is a leaving group (FORMULA) and hydrolysing the sulfate ester formed. Preferably the sulfate ester of formula II is prepared by the oxidation of a phenol of formula IV with a persulfate.

专利号:US-11414415-B2
优先权日:2020-04-23
标题 :6H-imidazo[4,5,1-ij]quinolone, synthesis method and use thereof
发明人：ZHANG PENGFEI; HUANG WEI; SHEN CHAO; XU JUN; SHEN JIABIN; XU WEIMING
权利人:UNIV HANGZHOU NORMAL
摘要:The present invention relates to the technical field of chemical synthesis of pharmaceutical chemicals, and provides a 6H-imidazo[4,5,1-ij]quinolone, a synthesis method and use thereof. 6H-imidazo[4,5,1-ij]quinolone derivatives provided by the present invention are a novel group of active quinolone derivatives, which have tumor cell inhibition activity and exhibit IC50 values equivalent to anti-lung cancer drug osimertinib; these quinolone derivatives have a broad application prospect in the preparation of antitumor drugs. The 6H-imidazo[4,5,1-ij]quinolone provided by the present invention is of high research and application value and has potential application prospects in fields of pharmaceutical chemicals, materials, dyes, etc. The present invention uses thioquinolinamide as a raw material to synthesize 6H-imidazo[4,5,1-ij]quinolones, featuring simple operation, excellent selectivity, high yield, mild reaction conditions, and easy product separation.

专利号:US-9505623-B1
优先权日:2014-06-24
标 题 :One-step synthesis of graphene quantum dots
发明人：QIN YIRU; Zhou shu-feng
权利人:QIN YIRU; Zhou shu-feng; UNIV SOUTH FLORIDA
摘要:Methods of making graphene quantums dots are provided. The methods can produce graphene quantum dots with a monodisperse size distribution. The graphene quantum dots are produced, via one-pot synthesis, from a graphene source and a strong oxidizing mixture at an elevated temperature. The strong oxidizing mixture can contain one or more permanganates and one or more oxidizing acids. Exemplary permanganates include sodium permanganate, potassium permanganate, and calcium permanganate. Exemplary oxidizing acids include nitric acid and sulfuric acid. The graphene quantum dots can have an average particle size of between about 1 nm and 20 nm and a monodisperse size distribution. For example, the size distribution can have a span about 1 or less and/or a coefficient of variance of about 0.5 or less. About 40% or more of the graphene quantum dots can have a diameter within ±5 nm of the average particle size of the graphene quantum dots.

专利号:US-10749177-B2
优先权日:2018-07-17
标 题 :Method of synthesizing phosphate salt of high purity for preparation of electrode material
发明人：HUANG GUIQING; MO BOSHAN; MO YOUDE
权利人:HUANG GUIQING; MO BOSHAN; MO YOUDE; GUANGXI NOWPHENE ENERGY STORAGE TECH CO LTD; BOSTON GLOBAL TECHNOLOGIES LLC
摘要:The present invention provides a cost-effective method of synthesizing phosphate salt of a metal M such as Fe and Mn that can be used for electrode active material of a lithium secondary battery. An oxidization-precipitation reaction is carried out on metal such as Fe(II) and Mn(II) to produce phosphate salt and hydroxide of the metal oxidized e.g. Fe(III) and Mn(III). With overdosed phosphoric acid, hydroxide of the oxidized metal is then converted to a phosphate salt. The invention also provides a method of preparing “wetâ€? phosphate salt nanoparticles and their application in the synthesis of a cathode material. The present invention exhibits numerous technical merits such as lower cost, easier operation, and being environmentally friendly.