CAS: 173054-11-0; (R)-3-(4-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)Phenyl)-2-((Tert-Butoxycarbonyl)Amino)Propanoic Acid

该化合物是一种受保护的氨酸衍生物,常用于peptide合成中,该化合物具有保护氨基组,在化学反应中通常用于保护氨基组;Fmoc(9-氟乙氧基碳基)组的存在表明,该物质在氨基位置也受到保护,允许在温和条件下有选择地进行保护."p-mino"指苯丙胺残留物的苯环上的配氨替代物,可影响化合物的再活性和相互作用.这种氨酸衍生物在固相聚聚物合成中特别有用,因为保护和非保护战略对于聚苯丙胺酯的成功组装配至关重要.其结构特征有助于其在生物化学和医药化学领域开发基于丙基的治疗和研究应用.

英文名称(R)-3-(4-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)Phenyl)-2-((Tert-Butoxycarbonyl)Amino)Propanoic Acid
中文名称Boc-D-4-(9-芴甲氧羰基氨基)苯丙氨酸
IUPAC名称(R)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
其它别名Boc-D-Phe(4-Nhfmoc)-Oh; (R)-3-(4-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)Phenyl)-2-((Tert-Butoxycarbonyl)Amino)Propanoic Acid; Boc-D-(4-Fmoc)-Aminophenylalanine; Boc-P-Amino-D-Phe(Fmoc)-Oh; Boc-D-(4-Fmoc)Aminophenylalanine; (2R)-3-[4-(9H-Fluoren
CAS编号173054-11-0
MFCD编号:MFCD00151888
分子式:C29H30N2O6
分子量:502.56
产品CID: 885132
产品分类生物化工 → 氨基酸及其衍生物 → 苯丙氨酸类衍生物

相似结构搜索
InChIKey: ZKSJJSOHPQQZHC-RUZDIDTESA-N
InChI=1S/C29H30N2O6/c1-29(2,3)37-28(35)31-25(26(32)33)16-18-12-14-19(15-13-18)30-27(34)36-17-24-22-10-6-4-8-20(22)21-9-5-7-11-23(21)24/h4-15…
计算化学: 氢键受体数6.0氢键供体数3.0可旋转键数10.0

物理性质

沸点671 °C at 760 mmHg
闪点359.6 °C
密度1.28g/cm3
pKa:3.90±0.10(预测)
PSA:113.96
LogP:6.0319
外观形态白色至类白色粉末
储存条件密封干燥,2-8°C
产品应用该化合物用作将PEPTIDES与GONADOTROPIN-RELEASING 激素对抗性活性合成.

上下游产品

L-N-tert-butoxycarbonyl-p-aminophenylalanine N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (2R)-3-(4-aminophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid80H102ClN15O13SC80H102ClN15O13S

合成工艺路线路线简述

海关参考信息

2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-9834113-A1
优先权日:1997-02-04
标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; HOUGHTEN RICHARD A; BLONDELLE SYLVIE E; SCHONER CHRISTA C
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-6359144-B1
优先权日:1997-02-04
标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
权利人:LION BIOSCIENCE AG
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.