📜4-甲氧基吡啶-N-氧化物置于palladium On Activated Charcoal 过氧乙酸,硼酸三甲酯,氢气,苯基锂体系中,化学反应生成3-羟基-4-甲氧基吡啶
参考文献:Total Synthesis Of The Antifungal Dilactones Uk-2A And Uk-3A: The Determination Of Their Relative And Absolute Configurations,Analog Synthesis And Antifungal Activities
标题:Total Synthesis Of The Antifungal Dilactones Uk-2A And Uk-3A: The Determination Of Their Relative And Absolute Configurations,Analog Synthesis And Antifungal Activities
摘要:The Synthesis Of The Antifungal Dilactones,Uk-2A And Uk-3A,Is Described. In Addition To Providing A Workable Synthetic Route To These Potent Antifungal Antibiotics,This Has Allowed Us To Determine The Assignment Of The Relative And Absolute Configurations In The Nine-Membered Ring. Furthermore,Uk-2A Analogs Were Also Synthesized And Evaluated Their Antifungal Activities And Cytotoxic Activities Along With Uk-2A,(2R,3R,4S,7R)-Uk-2A,Uk-3A,(2R,3R,4S,7R)-Uk-3A,And Antimycin A. The Structural Requirements For The Selective Cytotoxicity Against Yeasts And Filamentous Fungi Will Also Be Suggested. (C) 1998 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0040-4020(98)00777-7