CAS: 140-87-4; Cyanoacetohydrazide

该化合物是多用途有机化合物,分子式为C3H5N3O,具有西诺和氢氮功能组,其反应场有助于在热循环合成中应用,特别是用于制备,和三氮衍生物.该化合物是制药和农用化学研究的宝贵中间体,因为它能够形成稳定的环流手架.其高纯度和连续的再活动使它适合精细化学合成和催化剂发展.Cyanoacetohydazide还被用于化学协调,作为金属复合物的结链和结链.建议控制条件下的妥善处理,因为它对湿度和热度敏感.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号105-56-6 氰乙酸乙酯 | CAS号105-34-0 氰乙酸甲酯 | CAS号36140-83-7 1-氰基乙酰-3,5-二甲基吡唑 | CAS号141-82-2 丙二酸 | CAS号7664-41-7 氨 | CAS号7727-37-9 氮气 | CAS号4974-44-1 ACETIC ACID, CY... | CAS号120-46-7 二苯甲酰甲烷 | CAS号28491-52-3 5-氨基-1H吡唑-3-酮 | CAS号15119-34-3 香豆素-3腈 | CAS号30866-24-1 3-氧代-3-肼基丙酸乙酯 | CAS号65884-46-0 喹赛多(氰多司)

合成工艺路线路线简述

    📜氰乙酸乙酯置于肼体系中,用 乙醇 用作溶剂,化学反应生成氰乙酰肼
    参考文献:Combinatorial Synthesis Of 3,5-Dimethylene Substituted 1,2,4-Triazoles
    标题:Combinatorial Synthesis Of 3,5-Dimethylene Substituted 1,2,4-Triazoles
    摘要:通过相应的腈和羧酸分别生成的带有亚甲基连接r基团的咪达特和酰肼进行组合环化反应,提供了大量3,5-二亚甲基取代的1,2,4-三唑库.
    Doi:10.2174/138620711794474033

    海关参考信息

    专利信息


    专利号:US-2024400552-A1
    优先权日:2016-11-11
    标题 :Heterocyclic modulators of lipid synthesis
    发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11622968-B2
    优先权日:2011-03-08
    标 题:Heterocyclic modulators of lipid synthesis
    发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11034690-B2
    优先权日:2016-11-11
    标 题:Heterocyclic modulators of lipid synthesis
    发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-9809591-B2
    优先权日:2011-03-08
    标题 :Heterocyclic modulators of lipid synthesis
    发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
    权利人:3-V BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

    专利号:US-9868746-B2
    优先权日:2012-02-23
    标题:Substituted 5-aminothieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
    发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; TARR JAMES C; SALOVICH JAMES M; POSLUSNEY MICHAEL S
    权利人:UNIV VANDERBILT
    摘要:In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    专利号:WO-9600148-A1
    优先权日:1994-06-23
    标题 :Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof

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    主要参考文献


    1: POTWOROWSKA M. [Cyanoacetic acid hydrazide]. Gruzlica. 1956 Feb;24(2):129-36. Polish. German. Minerva Med. 1955 Sep 1;46(70):460-2. Italian. Minerva Med. 1955 Sep 1;46(70):462-8. Italian.
    6: SISTI MA, SCODITTI G. [Effect of cyanacetic acid hydrazide in anti-tuberculosis therapy on indices of organic resistance; clinico-functional studies]. Lotta Tuberc. 1957 Sep;27(9):760-2 passim. Italian. Czech. Italian. German. Minerva Med. 1955 Oct 27;46(86):1141-4. Italian. Spanish. German. Czech. German. German. Italian. Minerva Med. 1955 Sep 1;46(70):453-60. Italian. Italian. French.

    合成参考文献


    摘要:Zhang, J., Science of Synthesis Knowledge Updates, (2010) 4, 248.
    摘要:Hagen, T. J.; Helgren, T. R., Science of Synthesis Knowledge Updates, (2015) 2, 155.
    摘要:A. Albert. Nature 177, 525 (1956).
    摘要:S. Zommer and J. Szuszkiewicz. Chem. Anal. (Warsaw) 14, 1075 (1969); CA 72, 89616n.
    摘要:E. V. Titov, L. M. Kapkan, V. I. Rybachenko and N. G. Korzhenevskaya, Org. React. (USSR) 5, 273 (1968).
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