CAS: 135484-83-2; Methyl 2-Amino-4-Bromobenzoate

相似化合物

20776-50-5 59278-65-8 946122-05-0

上下游产品

2-氨基-4-溴苯甲酸 2-Amino-4-Bromobenzoic Acid 20776-50-5
2-硝基-4-溴苯甲酸甲酯 Methyl 4-Bromo-2-Nitrobenzoate 158580-57-5
4-溴-2-硝基苯甲酸 4-Bromo-2-Nitrobenzoic Acid 99277-71-1

6-溴靛红置于硫酸,Sodium Hydroxide体系中,化学反应 13.5H,反应生成2-氨基-4-溴苯甲酸甲酯
参考文献:一类新型4,5-取代-7-甲酸甲酯吲哚二酮衍生物 及其在抗肿瘤药物中的应用
标题:一类新型4,5-取代-7-甲酸甲酯吲哚二酮衍生物 及其在抗肿瘤药物中的应用
摘要:本发明涉及一类新型4,5-取代-7-甲酸甲酯吲哚二酮衍生物及其在抗肿瘤药物中的应用,所述衍生物为4-氟-5-溴-7-甲酸甲酯吲哚二酮,4-氟-5-硝基-7-甲酸甲酯吲哚二酮,4-氯-5-溴-7-甲酸甲酯吲哚二酮,4,5-二溴-7-甲酸甲酯吲哚二酮等.本申请合成出该类4,5-取代-7-甲酸甲酯吲哚二酮衍生物,并对其进行了体外肿瘤细胞抑制活性的测试,结果显示这类衍生物对人白血病细胞(K562),人结肠癌细胞(Ht-29)和人肝癌细胞(Hepg2)有一定的抑制作用(Ic50<10μm),在抗肿瘤药物开发应用方面具有广阔的前景.

专利信息

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.