CAS: 125-13-3; 3,3-Bis(4-Hydroxyphenyl)Indolin-2-One

上下游产品

3,3-dichloro-2,3-dihydro-1H-indol-2-one phenol indole-2,3-dione Phenyl acetate 2,4-Bis-(4-nitro-phenylazo)-phenol Bisatin 3,3-bis(4-methoxyphenyl)indolin-2-one

📜3,3-Dichloroindolin-2-One,苯酚 反应生成3,3-二(4-羟基苯基)-2(3H)-吲哚酮
参考文献:Inagaki,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1933,Vol. 53,P. 686,696;Dtsch.Ref.S.133
标题:Inagaki,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1933,Vol. 53,P. 686,696;Dtsch.Ref.S.133

专利信息

专利号:US-2007299102-A1
优先权日:2004-04-08
标题:Diphenyl Ox-Indol-2-One Compounds and Their Use in the Treatment of Cancer
发明人：FELDING JAKOB; PEDERSEN HANS C; KROG-JENSEN CHRISTIAN; PRAESTEGAARD MORTEN; BUTCHER STEVEN P; LINDE VIGGO; COULTER THOMAS S; MONTALBETTI CHRISTIAN; UDDIN MOHAMMED; REIGNIER SERGE
权利人:TOPOTARGET AS
摘要:The present invention relates to substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, and the use of such compounds for the preparation of a medicament for the treatment of cancer in a mammal. It is postulated that treatment of cancers is achieved in which inhibition of protein synthesis and/or inhibition of activation of the mTOR pathway is an effective method for reducing cell growth. Examples of such cancers are breast cancer, renal cancer, multiple myeloma, leukemia, glia blastoma, rhabdomyosarcoma, prostate, soft tissue sarcoma, colorectal sarcoma, gastric carcinoma, head and neck squamous cell carcinoma, uterine, cervical, melanoma, lymphoma, and pancreatic cancer. A particular subclass of compounds are represented by the formula (II) n n nwherein at least one of X 1 and X 2 is a heteroatom substituent, e.g. 6-chloro-3,3-bis-(4-hydroxy-phenyl)-7-methyl-1,3-dihydro-indol-2-one.

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优先权日:2016-07-19
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优先权日:2024-03-13
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