CAS: 106983-30-6; N-Octanoyl-Dl-Homoserine Lactone

相似化合物

87206-01-7 106983-28-2 98426-48-3

上下游产品

α-amino-γ-butyrolactone hydrobromide n-°Ctanoic acid chloride

📜α-氨基-γ-丁内酯氢溴酸盐,辛酰氯置于吡啶体系中,用 氯仿 用作溶剂,化学反应 16.0H,以67%的收率获得n-辛酰基-Dl-高丝氨酸内酯(2-8oc)
参考文献:Synthesis And Biological Evaluation Of New N-Acyl-Homoserine-Lactone Analogues,Based On Triazole And Tetrazole Scaffolds,Acting As Luxr-Dependent Quorum Sensing Modulators
标题:Synthesis And Biological Evaluation Of New N-Acyl-Homoserine-Lactone Analogues,Based On Triazole And Tetrazole Scaffolds,Acting As Luxr-Dependent Quorum Sensing Modulators
摘要:New Analogues Of N-Acyl-Homoserine-Lactone (Ahl),In Which The Amide Was Replaced By A Triazole Or Tetrazole Ring,Were Prepared And Tested For Their Activity As Luxr-Dependent Qs Modulators. Several Compounds Showed A Level Of Antagonistic Or Agonistic Activity,Notably Some 1,4-Triazolic And 1,5-Tetrazolic Derivatives,Whereas The 2,5-Tetrazolic Compounds Were Inactive. In 1,5-Tetrazoles,Substituted With Butyrolactone And An Alkyl Chain,The Activity Was Reversed,Depending On The Connection Between The Lactone And The Tetrazole. The C-N Connected Compounds Were Agonists Whereas The C-C Connected Ones Were Antagonists. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2012.06.007

专利信息

专利号:US-8222434-B1
优先权日:2009-04-04
标 题 :Bactobolin analog and synthesis method thereof
发明人：GREENBERG E PETER; CHANDLER JOSEPHINE R; DUERKOP BRECK; LIMA PATRICIA SILVA; BLODGETT JOSHUA ALAN; CLARDY JON; SEYEDSAYAMDOST MOHAMMAD R
权利人:GREENBERG E PETER; CHANDLER JOSEPHINE R; DUERKOP BRECK; LIMA PATRICIA SILVA; BLODGETT JOSHUA ALAN; CLARDY JON; SEYEDSAYAMDOST MOHAMMAD R; UNIV WASHINGTON CT COMMERCIALI; HARVARD COLLEGE
摘要:The present inventions are directed to a novel bactobolin analog bactobolin D. The present inventions also are directed to a method of producing a composition comprising at least one bactobolin analog using a bacteria strain comprising a bacterial cell comprising the biosynthetic locus of the bactobolin analog in Burkholderia thailandensis (bta cluster) or a homolog structure (at least 95% sequence identity) thereof, and further isolation and purification of the bactobolin analog. For example, the bacterial strain can be a wild type bacterial strain such as a Burkholderia strain comprising a bta cluster (e.g. Burkholderia thailandensis (e.g. E264, Bt4, and TXDOH) and Burkholderia pseudomallei (e.g. K96243, 1106a, and 1106b).

专利号:CN-115948483-A
优先权日:2022-12-30
标题:Method for enhancing synthesis of polyhydroxyalkanoate by bacteria based on quorum sensing signal molecules

专利号:CN-115948483-B
优先权日:2022-12-30
标 题 :A method for enhancing bacterial synthesis of polyhydroxyalkanoates based on quorum sensing signaling molecules