CAS: 1001-58-7; 3-Mercaptopropanenitrile

上下游产品

thioacetic acid acrylonitrile S‐(2‐cyanoethyl)isothiouronium chloride 3,3'-dithiobis(propionitrile) 1,4-Dithiane 3,3'-thiobis-propanenitrile 3,3'-dithiobis(propionitrile) 3-(4-nitrophenyldithio)propionitrile

📜丙烯腈置于硫化氢体系中,用 乙醇 用作溶剂,化学反应 1.0H,以86%的收率获得2-氰基乙硫醇
参考文献:一种硫醇化合物的制备方法
标题:一种硫醇化合物的制备方法
摘要:本发明提供了一种硫醇化合物的制备方法,即:在温度为20oc‑80°C,压力为0.10‑0.12Mpa的条件下,硫化氢与含有碳碳双键的有机化合物在固体碱催化剂和反应溶剂中经michael加成进行气液相反应制备硫醇化合物的方法.所述制备方法反应条件温和;所采用的固体碱催化剂碱性强,碱性催化位具有较大位阻作用,适用性广;固体碱催化剂容易过滤回收,经活化后可重复使用;反应转化率和选择性高,减少副反应的发生,反应的原子经济利用率高.

专利信息

专利号:US-6998484-B2
优先权日:2000-10-04
标 题:Synthesis of purine locked nucleic acid analogues
发明人：KOCH TROELS; JENSEN FLEMMING REISSIG
权利人:SANTARIS PHARMA AS
摘要:The present invention relates to a new method for the synthesis of purine LNA (Locked Nucleic Acid) analogues which provides a higher overall yield. The method comprising a regioselective 9-N purine glycosylation reaction followed by a one-pot nucleophilic aromatic substitution reaction of the 6-substituent in the purine ring and simultaneous nucleophile-induced intramolecular ring closure of the C-branched carbohydrate to form novel purine LNA analogues. The novel strategy is illustrated by the synthesis of the novel compound (1S,3R,4R,7S)-7-benzyloxy-1-methanesulfonylmethyl-3-(guanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane which is easily converted into (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-((2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane after isobutyryl protection of the 2-amino purine group and subsequent substitution of 1-methanesulfonyl with benzoate, debenzoylation and debenzylation.

专利号:US-6291620-B1
优先权日:1994-11-09
标 题:Polymer synthesis
发明人：MOAD GRAEME; MOAD CATHERINE LOUISE; KRSTINA JULIA; RIZZARDO EZIO; DARLING THOMAS ROBERT; BERGE CHARLES THOMAS
权利人:DU PONT; COMMW SCIENT IND RES ORG
摘要:Process for the synthesis of block polymers, homopolymers and copolymers of narrow polydispersity having formula (1) by contacting selected vinyl monomer(s), vinyl-terminated compound(s) and free radicals in which effective control of production of polymer is achieved by controlling the mole ratio of vinyl monomer(s), vinyl-terminated compound(s) and free radicals relative to one another; and polymers produced thereby

专利号:US-8710210-B2
优先权日:2010-06-30
标题:Method of using N-thio compounds for oligonucleotide synthesis
发明人：HE YIGANG; SOROKIN VICTOR; MAZUR WIESLAW ADAM
权利人:HE YIGANG; SOROKIN VICTOR; MAZUR WIESLAW ADAM; GIRINDUS AMERICA INC
摘要:A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the oligonucleotide, wherein R is an aryl group or a heteroaryl group, which is bonded to the S-atom through an annular carbon atom; and R 1 and R 2 are independently organic residues, preferably a C1-C20 hydrocarbon residue. The method may further comprise purifying the oligonucleotide. Also included is a process for the synthesis of the sulfurizing agent.

专利号:US-7019127-B2
优先权日:1997-08-13
标 题 :Solution phase synthesis of oligonucleotides
发明人：REESE COLIN BERNARD; SONG QUANLAI
权利人:AVECIA LTD
摘要:A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a coupling agent to form an H-phosphonate diester. The H-phosphonate diester is oxidised in situ with a sulfur transfer agent to produce the phosphorothioate triester. Preferably, the H-phosphonate and alcohol are protected nucleosides or oligonucleotides. Oligonucleotide H-phosphonates which can be used in the formation of phosphorothioate triesters are also provided.

专利号:US-5856501-A
优先权日:1997-03-11
标题 :Synthesis of thiazole derivatives
发明人：MALCOLM ARCELIO J; WU TSE-CHONG
权利人:ALBEMARLE CORP
摘要:N- 4-(cyanoethylthiomethyl)-2-thiazolyl!guanidine--a key intermediate for preparing the pharmaceutical, famotidine--is produced by mixing in a liquid medium formed from a chemically indifferent organic solvent and water, and under an inert atmosphere, (i) a 2-guanidino-4-halomethylthiazole or a hydrohalide complex thereof, (ii) an S-(2-cyanoethyl)isothiourea or a hydrohalide complex thereof, and (iii) a strong alkali metal base. In lieu of (ii), an alkali metal salt of 2-cyanoethyl-1-thiol can be used, and in such case use of (iii) is optional, but preferable.

专利号:WO-0127126-A1
优先权日:1999-10-14
标题 :Process for the preparation of phosphorothioate triesters and oligonucleotides
发明人：DOUGLAS MARK EDWARD; SCOTT KEVIN GERARD
权利人:AVECIA LTD; DOUGLAS MARK EDWARD; SCOTT KEVIN GERARD
摘要:A process for the synthesis of a phosphorothioate triester is provided. The process comprises the reaction, in the presence of a coupling agent, of an H-phosphonate with a substrate comprising a free hydroxy group and bonded to a solid support, thereby forming a supported H-phosphonate diester, and subjecting the H-phosphonate diester to sulphur transfer with a sulphur transfer agent.