苄基三甲基氯化铵置于ionac Na-38 [oh(-) Form]体系中,化学反应生成苄基三甲基氢氧化铵 参考文献:Guest−host Interactions In As-Made Al-Zsm-12: Implications For The Synthesis Of Zeolite Catalysts 标题:Guest−host Interactions In As-Made Al-Zsm-12: Implications For The Synthesis Of Zeolite Catalysts 摘要:Al-Zsm-12 Samples Have Been Prepared With Selectively Deuterated Benzyltrimethylammonium Cations As Structure-Directing Agents (Sdas) To Study The Motion Of The Sda And The Spatial Relationships Between The Sda And The Zeolite Framework. H-2 NMR Shows The Methyl Groups Of The Structure-Directing Agent Undergo At Least Two Rapid Rotations While The Benzyl Segment Is Essentially Immobile,Undergoing Only Small Angle Wobbling Motions,Cross-Polarization And Rotational Echo Double Resonance NMR Experiments Were Performed To Study The Spatial Relationships Between The Sda And The Framework Silicon And Aluminum. The Results From The Cpmas And Redor Experiments Show The Methylene Protons Of The Structure-Directing Agent Are Preferentially Located Near The Silicon Atoms Adjacent To The Framework Aluminum. As A Consequence There Is Relative Charge Ordering Between The Sda And The Framework Aluminum,Suggesting That The Framework Aluminum Is Directly Associated With The Charge Center Of The Sda. Given The Reduced Number Of Configurations Accessible To The Sdas In The As-Made Material,We Believe The Results Suggest A Possible Route To Tailoring The Spatial Arrangement Of Trivalent Framework Atoms Through Selection Of Sdas With Appropriate Charge Distributions. Doi:10.1021/jp992549U
专利信息
专利号:US-2024294462-A1 优先权日:2023-02-15 标题:Method for the Synthesis of Ionizable Lipids Using a Doubly Alkylated Intermediate 发明人:SAADATI FARIBA; TRAN HUY; CIUFOLINI MARCO; ATMURI N D PRASAD 权利人:NANOVATION THERAPEUTICS INC 摘要:Provided herein is a method for the preparation of ionizable, cationic amino lipids using a doubly alkylated nucleophilic intermediate to produce a ketone. The ketone, or a corresponding alcohol, is subjected to one or more synthesis steps to add an ionizable moiety thereto. The method can be advantageously employed for the synthesis of unsymmetrical analogues of the above lipids that would be considerably more difficult to make by alternative strategies. The method can also be used to prepare symmetrical ionizable, cationic amino lipids with fewer steps and/or with the use of fewer hazardous chemicals than known synthesis methods.
专利号:US-10865116-B2 优先权日:2017-03-24 标 题:Process for the synthesis of IZM-2 zeolite in the presence of a template, 1,6-bis(methylpiperidinium)hexane dihydroxide 发明人:MARTINEZ FRANCO RAQUEL; BATS NICOLAS 权利人:IFP ENERGIES NOW 摘要:A novel process is described for the preparation of a microporous crystalline solid, known as IZM-2 microporous solid or IZM-2 zeolite. This novel process consists of carrying out the synthesis of IZM-2 zeolite by conversion/transformation of a zeolite with structure type FAU in a fluorinated medium under hydrothermal conditions. In particular, said novel process consists of carrying out the synthesis of an IZM-2 zeolite in a fluorinated medium starting from a zeolite with structure type FAU used as the source of silicon and aluminium and a specific organic molecule or template comprising two quaternary ammonium functions, namely 1,6-bis(methylpiperidinium)hexane dihydroxide.
专利号:US-2005101763-A1 优先权日:2003-09-30 标 题 :Synthesis of photolabile 2-(2-nitrophenyl)propyloxycarbonyl protected amino acids 发明人:DELISI CHARLES P; LAURSEN RICHARD A; BHUSHAN KUMAR R 权利人:UNIV BOSTON 摘要:The 2-(2-nitrophenyl)propyloxycarbonyl (NPPOC) group has been introduced as a photolabile amino protecting group for amino acids to be used as building blocks in photolithographic solid-phase peptide synthesis. NPPOC-protected amino acids were found to be cleaved in the presence of UV light about twice as fast as the corresponding o-nitroveratryloxycarbonyl (NVOC)-protected amino acids. The protected amino acids are of particular use in the synthesis of peptide arrays.
专利号:US-2008103312-A1 优先权日:2006-08-29 标 题:Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole 发明人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D 权利人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D 摘要:Provided are processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole, an intermediate useful in the synthesis of irbesartan.
专利号:US-10875778-B2 优先权日:2017-03-24 标 题 :Process for the synthesis of IZM-2 zeolite in the presence of a template, 1,6-bis(methylpiperidinium)hexane dibromide 发明人:MARTINEZ FRANCO RAQUEL; BATS NICOLAS 权利人:IFP ENERGIES NOW 摘要:A novel process is described for the preparation of a microporous crystalline solid, known as IZM-2 microporous solid or IZM-2 zeolite. This novel process consists of carrying out the synthesis of IZM-2 zeolite by conversion/transformation of a zeolite with structure type FAU under hydrothermal conditions. In particular, said novel process consists of carrying out the synthesis of an IZM-2 zeolite starting from a zeolite with structure type FAU used as the source of silicon and aluminium and a specific organic molecule or template comprising two quaternary ammonium functions, namely 1,6-bis(methylpiperidinium)hexane dibromide.
专利号:EP-0439404-B1 优先权日:1990-01-25 标题 :Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom 发明人:KHATRI HIRALAL N; DEHOFF BRADLEY S 权利人:SANOFI SA 摘要:An improved process for the synthesis of 2-(2 min -thienyl)ethylamine from suitably functionalized derivatives of 2-(2 min -thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2 min -thienyl)ethylamine produced by this process is advantageously converted to the carbamic acid salt, which is suitably reconverted to 2-(2 min -thienyl)ethylamine, a useful intermediate in the synthesis of ticlopidine.
参考文献:10.1007/s11010-011-0953-8 摘要:Makowska M, Łukowska-Chojnacka E, Wińska P, Kuś A, Bilińska-Chomik A, Bretner M. Design and synthesis of CK2 inhibitors. Molecular and Cellular Biochemistry. 2011 Jul 13;356(1-2):91. doi: 10.1007/s11010-011-0953-8.