CAS: 99-04-7; 3-Methylbenzoic Acid(Flakes Or Chunks Or Granular)

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CAS号108-38-3 间二甲苯 | CAS号201230-82-2 carbon monoxide | CAS号591-17-3 3-溴甲苯 | CAS号312693-24-6 3-甲基苯基碘化锌溶液 | CAS号124-38-9 二氧化碳 | CAS号585-74-0 间甲基苯乙酮 | CAS号587-03-1 3-甲基苄醇 | CAS号1422-76-0 m-methylbenzene... | CAS号121612-23-5 2-羟基-1-(3-甲基苯基)乙酮 | CAS号618-51-9 间碘苯甲酸 | CAS号105576-60-1 4-amino-3-(3-me... | CAS号4316-23-8 4-甲基邻苯二甲酸 | CAS号3113-72-2 5-甲基-2-硝基苯甲酸 | CAS号3113-71-1 3-甲基-4-硝基苯甲酸 | CAS号5437-38-7 3-甲基-2-硝基苯甲酸 | CAS号3478-09-9 3-methyl-2,6-di... | CAS号41295-28-7 甲氧苯酮 | CAS号4389-45-1 2-氨基-3-甲基苯甲酸 | CAS号31719-77-4 3-(氯甲基)苯甲酸 | CAS号5471-82-9 3-甲基-2-硝基苯甲酸甲酯

3-甲基苄胺置于叔丁基过氧化氢体系中,用 水,乙腈 作为反应溶剂,化学反应 24.0H,以73%的收率获得产物间甲基苯甲酸
参考文献:通过串联邻萘醌催化和 Tbhp 促进的氧化序列将伯胺一锅直接氧化成羧酸
标题:通过串联邻萘醌催化和 Tbhp 促进的氧化序列将伯胺一锅直接氧化成羧酸
摘要:胺到羧酸的串联氧化序列是通过o-Nq 催化的胺有氧氧化成亚胺,然后是自由基引发的 Tbhp 促进的亚胺中间体氧化.从机制上讲,通过 Tbai 的帮助促进了o-Nq 催化剂体系的选择性亚胺形成,这在随后 Tbhp 促进的亚胺衍生物氧化以将亚胺分解为醛和胺中也很关键.反过来,释放的胺重新进入o-Nq 催化循环以产生亚胺中间体.
DOI:10.1002/chem.202103450

专利信息

专利号:US-5977301-A
优先权日:1992-09-24
标题 :Synthesis of N-substituted oligomers
发明人：ZUCKERMAN RONALD N; KERR JANICE M; KENT STEPHEN B H; MOOS WALTER H; SIMON REYNA J; GOFF DANE A
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a resin-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability.

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-4400550-A
优先权日:1982-02-12
标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal
发明人：BISHOP CLYDE E; MORROW GARY W
权利人:ALBANY INT CORP
摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.

专利号:US-6525061-B1
优先权日:1999-11-16
标题 :Methods for the solid phase synthesis of 2-amino-4(H)-quinazolinone derivatives
发明人：GOPALSAMY ARIAMALA; YANG HUI Y
权利人:WYETH CORP
摘要:The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I):having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:WO-2013144924-A1
优先权日:2012-03-29
标 题:An improved process for the synthesis of strobilurin fungicides viz trifloxystrobin and kresoxim-methyl
发明人：KAMARAJ PASUMPON; SATAM VIJAY SHRIKANT; AJJANNA MAHALINGAPPA SRIDHARA; NANDI TAPASKUMAR; BOBADE ANNA; SHINDE RAVINDRA; NAIK PARAG; MOHITE DHANAJI; KADAM SUBHASH; HINDUPUR RAMA MOHAN; PATI HARI NARAYAN; MANE AVINASH; VADIRAJ SUPHALA GOPINATH; VENKATESH PRABHU MOODBIDRI
权利人:RALLIS INDIA LTD
摘要:The present invention relates to an improved process for the synthesis of E -isomer of compound of formula (5). It further relates to the conversion of formula (5), wherein R is H, to Intermediate (I) and subsequently to substantially pure Trifloxystrobin, compound of formula (I) in good yield.

专利号:WO-2021033172-A1
优先权日:2019-08-20
标题:Process for the preparation of chlorantraniliprole
发明人：V ASHWIN; PRADHAN ASHOK KUMAR; PALIMKAR SANJAY SAMBHAJIRAO; MANE AVINASH SHESHRAO; KUNHIMON SYAM KUMAR UNNIARAN
权利人:EUROFINS ADVINUS LTD
摘要:The present invention relates to two novel, efficient and one-pot methods for synthesizing chlorantraniliprole. In the first scheme, Chlorantraniliprole is prepared by a novel telescopic process starting from 3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid a key raw material-A (Key RM-A). In the second scheme, starting from Key RM-A, the process steps use of a novel variant of anthranilic acid (Methyl 2-amino-5-chloro-3-methylbenzoate), to get Chlorantraniliprole. Furthermore, the present invention also relates to the synthesis of key starting material for the synthesizing chlorantraniliprole in-situ. All the in-situ steps of the disclosed synthesis methods obtain good yield, without using any expensive reagent or base or harsh reaction conditions, which makes the process simple, environment friendly and more cost effective. With this process the production cost of chlorantraniliprole and its intermediates is substantially reduced; fewer by-products are formed during its synthesis and since it's a one-pot reaction, isolation and purification are easy to achieve.