CAS: 932-77-4; 1-Bromo-3-(Chloromethyl)Benzene

该化合物是一种有机化合物,其特点是存在溴原子和附于苯环的氯甲基组,在室内温度下,它是一种无色的黄色淡液,具有独特的芳香味,它被归类为烷基卤化物,以其反应性为名,特别是因其在氯甲基组中存在电活性碳而导致的核生殖替代反应而闻名.其分子结构具有一种溴原子,它位于苯环上与氯甲基组相对的位置,影响其化学行为和再活动. 3-Bromobenzyl氯化物在诸如乙醚和氯仿等有机溶剂中溶解,但水中的溶解性有限.它被用于各种用途,包括作为合成制药,农业化学品和其他有机化合物的中间体.与许多卤化化合物一样,它在处理时应当考虑到潜在的毒性和环境关切.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号15852-73-0 3-溴苯甲醇 | CAS号591-17-3 3-溴甲苯 | CAS号583-68-6 2-溴-4-甲基苯胺 | CAS号7791-25-5 磺酰氯 | CAS号94-36-0 过氧化苯甲酰 | CAS号123-91-1 1,4-二氧六环 | CAS号7647-01-0 盐酸 | CAS号456-43-9 3-(fluoromethyl... | CAS号107558-73-6 2-(3-溴苄基)丙二酸二乙酯 | CAS号42287-90-1 3-(3-溴苯基)丙酸 | CAS号90433-27-5 3-(3-甲基-3-丁烯-1-基)溴苯 | CAS号39959-54-1 3-溴苄胺盐酸盐 | CAS号90433-28-6 4-(3-CYANOPHENY... | CAS号20600-29-7 1-溴-3-(苯氧基甲基)苯 | CAS号876473-54-0 2-(3-bromo-benz... | CAS号18257-89-1 1-3 -烯丙基溴苯 | CAS号34598-49-7 5-溴-1-茚酮 | CAS号1878-67-7 3-溴苯乙酸

合成工艺路线路线简述

  • 15852-73-0 = 932-77-4
    反应条件:1.1 Reagents: Phosphorus Pentachloride
    标题:Solvophobically Driven π-Stacking Of Phenylene Ethynylene Macrocycles And Oligomers
    作者:Lahiri,Shreyasi; Thompson,Julie L.; Moore,Jeffrey S.
    参考文献:Journal Of The American Chemical Society 日期:2000 卷标:122(46) 页码:11315-11319]

    15852-73-0 = 932-77-4
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dimethylformamide,Dichloromethane; 0 °C; 1 H,Rt
    标题:Site-Selective Carbonylation Of Arenes Via C(Sp2)-H Thianthrenation: Direct Access To 1,2-Diarylethanones
    作者:Zhang,Jiajun; Wang,Le-Cheng; Bao,Zhi-Peng; Wu,Xiao-Feng
    参考文献:Chemical Science 日期:2023 卷标:14(28) 页码:7637-7641]

    = 932-77-4 [标题:Reaction Conditions
    标题:Neurotropic And Psychotropic Substances. Xvi. Derivatives Of 5,6,7,8,9,10-Hexahydro-5,9,-Methanobenzocyclooctene And Its Lower Homolog
    作者:Adlerova,Edita; Protiva,Miroslav
    参考文献:Collection Of Czechoslovak Chemical Communications 日期:1967 卷标:32 页码:3177-85]

    15852-73-0 = 932-77-4 + 98-11-3
    反应条件:1.1 Reagents: N-Methyl-2-Pyrrolidone,Oxygen Solvents: 1,2-Dichloroethane; 1.5 H,80 °C
    标题:Nmp-Mediated Chlorination Of Aliphatic Alcohols With Aryl Sulfonyl Chloride For The Synthesis Of Alkyl Chlorides
    作者:Zheng,Dagui; Mao,Liu-Liang; Zhu,Xian-Hong; Zhou,An-Xi
    参考文献:Synthetic Communications 日期:2018 卷标:48(21) 页码:2793-2800]

    15852-73-0 = 932-77-4 + 823-78-9
    反应条件:1.1 Reagents: Cyanuric Chloride Solvents: Dimethylformamide; 25 °C1.2 Reagents: Sodium Bromide Solvents: Dichloromethane; 10 H,25 °C1.3 25 Min,Rt
    标题:A Chemoselective,Easy Bromination Of (Hydroxymethyl)Phenols
    作者:Nieddu,Giammario; De Luca,Lidia; Giacomelli,Giampaolo
    参考文献:Synthesis 日期:2008 卷标:(24) 页码:3937-3940]

    3132-99-8 = 932-77-4
    反应条件:1.1 Reagents: Titanium Tetrachloride,Ammonia Borane Solvents: Dichloromethane; 0 °C; 1 Min,0 °C; 3 H,Rt; Rt -> 0 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 0 °C
    标题:Balancing Lewis Acidity And Carbocation Stability For The Selective Deoxyhalogenation Of Aryl Carbonyls And Carbinols
    作者:Ramachandran,P. Veeraraghavan; Alawaed,Abdulkhaliq A.; Hamann,Henry J.
    参考文献:Organic Letters 日期:2023 卷标:25(25) 页码:4650-4655]

    15852-73-0 = 932-77-4
    反应条件:1.1 Reagents: Tetrabutylammonium Iodide,Triphenylphosphine Solvents: 1,2-Dichloroethane; 0.5 H,120 °C
    标题:Halogenation Through Deoxygenation Of Alcohols And Aldehydes
    作者:Chen,Jia; Lin,Jin-Hong; Xiao,Ji-Chang
    参考文献:Organic Letters 日期:2018 卷标:20(10) 页码:3061-3064]

    15852-73-0 = 932-77-4
    反应条件:1.1 Reagents: Tosyl Chloride,1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Dichloromethane; 0 °C -> Rt; 10 Min,Rt
    标题:Facile Chlorination Of Benzyl Alcohols Using 1,8-Diazabicyclo[5.4.0]Undec-7-Ene (Dbu) And Sulfonyl Chlorides
    作者:Kim,Hyung Woo; Lee,Yun-Sang; Shetty,Dinesh; Lee,Hak Jeong; Lee,Dong Soo; Et Al
    参考文献:Bulletin Of The Korean Chemical Society 日期:2010 卷标:31(11) 页码:3434-3436]

    15852-73-0 = 932-77-4
    反应条件:1.1 Reagents: Thionyl Chloride; 30 Min; 2 H
    标题:Syntheses Of Compounds Active Toward Glutamate Receptors: Ii. Synthesis Of Spiro Hydantoins Of The Indan Series
    作者:Matveeva,E. D.; Podrugina,T. A.; Morozkina,N. Yu.; Zefirova,O. N.; Seregin,I. V.; Et Al
    参考文献:Russian Journal Of Organic Chemistry (Translation Of Zhurnal Organicheskoi Khimii) 日期:2002 卷标:38(12) 页码:1769-1774]

    = 932-77-4 [标题:Reaction Conditions
    标题:Process And Lewis Acid Catalysts For The Chloromethylation Of Aromatic Hydrocarbons And Aromatic Group-Containing (Co)Polymers With Chloromethyl Methyl Carbonate
    参考文献:Belgium]

    = 932-77-4 [标题:Reaction Conditions
    标题:N-(Arylalkoxy)-2-Pyrimidinecarboximidamides,A Method For Their Preparation And Their Use As Pesticides And Agrochemical Fungicides
    参考文献:European Patent Organization]

    = 932-77-4 [标题:Reaction Conditions
    标题:Simultaneous Preparation Of Benzyl Chlorides And Aromatic Acid Amides
    参考文献:Japan]

    = 932-77-4 [标题:Reaction Conditions
    标题:Simultaneous Preparation Of Aromatic Acid Amides And Benzyl Chlorides
    参考文献:Japan
📜3-溴苯甲醇置于n-甲基吡咯烷酮,苯磺酰氯体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 1.5H,以97%的收率获得产物3-溴苄氯
参考文献:Nmp 介导的脂肪醇氯化与芳基磺酰氯用于合成烷基氯
标题:Nmp 介导的脂肪醇氯化与芳基磺酰氯用于合成烷基氯
摘要:摘要 Nmp 介导的脂肪醇氯化已被开发用于合成烷基氯.这种简便,高效和实用的方法使用简单易得的芳基磺酰氯作为氯化试剂,在温和的条件和广泛的底物范围内以非常好到优异的收率构建 C-Cl 键.图形概要
DOI:10.1080/00397911.2018.1482498

海关参考信息

专利信息


专利号:DK-2137202-T3
优先权日:2007-03-14
标题:PROCEDURE FOR SYNTHESIS OF IB-MECA

专利号:HU-E034474-T2
优先权日:2007-03-14
标题:Method for the synthesis of IB-meca

专利号:PT-2137202-T
优先权日:2007-03-14
标 题:PROCESS FOR THE SYNTHESIS OF IB-MECA

专利号:EP-2137202-B1
优先权日:2007-03-14
标 题:Process for the synthesis of ib-meca

专利号:WO-0039055-A1
优先权日:1998-12-23
标 题:Rapid purification by polyaromatic quench reagents
发明人：DA SILVA MARIANNE; DOWNING DENNIS MICHAEL; WARMUS JOSEPH SCOTT; ZHANG LU-YAN
权利人:WARNER LAMBERT CO; DA SILVA MARIANNE; DOWNING DENNIS MICHAEL; WARMUS JOSEPH SCOTT; ZHANG LU YAN
摘要:Novel polyaromatic hydrocarbon quenching reagents of Formula (I), wherein: P is a polyaromatic hydrocarbon of low chemical reactivity which is soluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers or dendritic linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

专利号:WO-2016091228-A1
优先权日:2014-12-11
标题 :Substituted phenyltetrazole, its use and pharmaceutical preparation containing it
发明人：ROH JAROSLAV; NEMECEK JAN; HRABALEK ALEXANDR; KLIMESOVA VERA; KARABANOVICH GALINA; PAVEK PETR; SYCHRA PAVEL
权利人:UNIV KARLOVA
摘要:A nitro group-substituted phenyltetrazole of general formula (I) wherein R is selected from the group consisting of: H, C 1 -C 11 alkyl, phenyl- or phenyl- substituted in positions 2, 3, 4 or 5 by one or more electron-acceptor groups and/or by one or more electron-donor groups. These compounds can be prepared by easy synthesis and have significant activity against mycobacteria including their multidrug resistant strains. The invention provides also a pharmaceutical preparation having nitro group-substituted phenyltetrazole of formula (I) as the active ingredient, as well as the use of this nitro group-substituted phenyltetrazole as antituberculosis drug.

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合成参考文献


参考文献:10.1007/bf01518661
参考文献:10.1023/a:1022567630253
摘要:Matveeva ED, Podrugina TA, Morozkina NY, Zefirova ON, Seregin IV, Bachurin SO, Pellicciari R, Zefirov NS. Syntheses of Compounds Active toward Glutamate Receptors: II. Synthesis of Spiro Hydantoins of the Indan Series. Russian Journal of Organic Chemistry. 2002 Dec;38(12):1769–74. doi: 10.1023/a:1022567630253.
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