CAS: 74285-86-2; (3Br,9Bs)-6-Hydroxy-7-Isopropyl-9B-Methyl-3B,4,5,9B,10,11-Hexahydrophenanthro[1,2-C]Furan-1(3H)-One

相似化合物

74311-48-1 1209485-40-4 79548-61-1

上下游产品

(3Br-反式)-3B,4,5,9B,10,11-六氢-6-甲氧基-9B-甲基-7-(1-甲基乙基)-菲并(1,2-C)呋喃-1(3H)-酮 (3Br,9Bs)-7-Isopropyl-6-Methoxy-9B-Methyl-3B,4,5,9B,10,11-Hexahydrophenanthro[2,1-C]Furan-1(3H)-One 74311-48-1
Trifluoro-Methanesulfonic Acid (4As,10Ar)-1-Hydroxymethyl-7-Isopropyl-8-Methoxy-4A-Methyl-3,4,4A,9,10,10A-Hexahydro-Phenanthren-2-Yl Ester 238746-44-6
(4As,10Ar)-7-Isopropyl-8-Methoxy-4A-Methyl-2-Trifluoromethanesulfonyloxy-3,4,4A,9,10,10A-Hexahydro-Phenanthrene-1-Carboxylic Acid (1S,2R,5S)-5-Methyl-2-(1-Methyl-1-Phenyl-Ethyl)-Cyclohexyl Ester 238746-43-5
(1S,4As,10As)-7-Isopropyl-8-Methoxy-4A-Methyl-2-Oxo-1,2,3,4,4A,9,10,10A-Octahydro-Phenanthrene-1-Carboxylic Acid (1S,2R,5S)-5-Methyl-2-(1-Methyl-1-Phenyl-Ethyl)-Cyclohexyl Ester 238746-42-4

(3Br-反式)-3B,4,5,9B,10,11-六氢-6-甲氧基-9B-甲基-7-(1-甲基乙基)-菲并(1,2-C)呋喃-1(3H)-酮置于三溴化硼体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,以99%的收率获得产物雷酚内酯
参考文献:(-)-雷公藤内酯,(-)-雷公藤内酯,(+)-雷公藤内酯和(+)-雷公藤内酯的对映选择性全合成.
标题:(-)-雷公藤内酯,(-)-雷公藤内酯,(+)-雷公藤内酯和(+)-雷公藤内酯的对映选择性全合成.
摘要:(-)-雷公藤甲素(1),(-)-雷公藤酮(2),(+)-雷公藤酚(3)和(+)-雷公醌(4)的第一对映选择性全合成完成.关键步骤涉及镧系元素三氟甲磺酸盐催化由mn(oac)3介导的(+)-8-苯基薄荷基酯30的氧化自由基环化,为中间体31提供了非常好的化学收率(77%)和出色的非对映选择性(dr 38:1).然后以＞ 99%对映体过量(＞ 99%ee)制备(+)-三苯酚甲醚(5),并容易地转化为天然产物1-4.此外,提出了过渡态模型来解释在手性β-酮酯17(无α-取代基)和17A(有α-氯取代基)的氧化自由基环化反应中观测到的相反的手性诱导作用.
DOI:10.1021/jo9919613

专利信息

专利号:US-2025263763-A1
优先权日:2020-08-27
标 题 :Production of oxygenated diterpenoid compounds
发明人：ANDERSEN-RANBERG JOHAN; HANSEN NIKOLAJ; FORMAN VICTOR
权利人:UNIV COPENHAGEN
摘要:Disclosed is a method for production of oxygenated diterpenoid compounds, such as triptophenolide, triptonide and triptolide, by inserting genes encoding particular cytochrome P450 enzymes and expressing the genes in selected host cells for synthesis of the compounds. Further disclosed are particular cytochrome P450 enzymes suitable for this synthesis.

专利号:WO-2022043461-A1
优先权日:2020-08-27
标 题 :Production of oxygenated diterpenoid compounds
发明人：ANDERSEN-RANBERG JOHAN; HANSEN NIKOLAJ; FORMAN VICTOR
权利人:UNIV COPENHAGEN
摘要:Disclosed is a method for production of oxygenated diterpenoid compounds, such as triptophenolide, triptonide and triptolide, by inserting genes encoding particular cytochrome P450 enzymes and expressing the genes in selected host cells for synthesis of the compounds. Further disclosed are particular cytochrome P450 enzymes suitable for this synthesis.