CAS: 621-03-4; 2-Cyano-N-Phenylacetamide

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Benzoylacetonitrile phenyl is°Cyanate cyanoacetic acid potassium cyanide 3-amino-propionanilide (E)-3-(benzo[d][1,3]dioxol-5-yl)-2-cyano-N-phenylacrylamide 2-cyano-3ξ-(6-nitro-benzo[1,3]dioxol-5-yl)-acrylic acid anilide α-cyanobenzoylacetanilide

📜氰乙酸置于1-羟基苯并三唑,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,三乙胺体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以46%的收率获得产物2-氰基乙酰苯胺
参考文献:Discovery,Structure-Activity Relationship Study And Biological Evaluation Of 2-Thioureidothiophene-3-Carboxylates As A Novel Class Of C-X-C Chemokine Receptor 2 (Cxcr2) Antagonists
标题:Discovery,Structure-Activity Relationship Study And Biological Evaluation Of 2-Thioureidothiophene-3-Carboxylates As A Novel Class Of C-X-C Chemokine Receptor 2 (Cxcr2) Antagonists
摘要:The C-X-C Motif Ligand 8 And C-X-C Chemokine Receptor 2 (Cxcl8-Cxcr2) Axis Is Involved In Pathogenesis Of Various Diseases Including Inflammation And Cancers. Various Cxcr2 Antagonists Are Under Development For Several Diseases. Our Previous High-Throughput Cell-Based Assay Specific For Cxcr2 Has Identified A Pyrimidine-Based Compound Cx797 Acting On Cxcr2 Down-Stream Signaling. A Lead Optimization Campaign Through Scaffold-Hopping Strategy Led To A Series Of 2-Thioureidothiophene-3-Carboxylates (Tutp) As Novel Cxcr2 Antagonists. Structure-Activity Relationship Study Of Tutps Led To The Identification Of Compound 52 That Significantly Inhibited Cxcr2-Mediated Beta-Arrestin Recruitment Signaling (Ic50 = 1.1 +/-0.01 Mu M) With Negligible Effect On Cxcl8-Mediated Camp Signaling And Calcium Flux. Similar To The Known Cxcr2 Antagonist Sb265610,Compound 52 Inhibited Cxcl8-Cxcr2 Induced Phosphorylation Of Erk1/2. Tutp Compounds Also Inhibited Cxcl8-Mediated Cell Migration And Showed Synergy With Doxorubicin In Ovarian Cancer Cells,Thereby Supporting Tutps As Promising Compounds For Cancer Treatment. (C) 2020 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2020.112387

专利信息

专利号:WO-0031040-A1
优先权日:1998-11-23
标 题 :Process for preparing bis n-substituted perylenetetra carboximides via bis (hydroxymethyl) perylenetetra carboximide
发明人：HENDI SHIVAKUMAR BASALINGAPPA
权利人:CIBA SC HOLDING AG
摘要:Process for preparing a bis (hydroxymethyl) perylenetetra carboximide compound by reacting perylene-3,4,9,10-tetracarboximide with formaldehyde. The bis (hydroxymethyl) perylenetetra carboximide can be isolated or further reacted in a one pot synthesis to yield a compound of formula (I), wherein X1 and X2, each independently of the other, are organic radicals, D is chlorine or bromine, and n is an integer from 0 to 4; which perylene derivative contains from 0 to 6 moles of -SO3M per mole of the perylene derivative; wherein M is hydrogen or a metal or ammonium cation.

专利号:US-5919945-A
优先权日:1996-06-05
标题 :Process for preparing diketopyrrolopyrrole derivatives
发明人：HENDI SHIVAKUMAR BASALINGAPPA
权利人:CIBA SC HOLDING AG
摘要:This disclosure relates to a process for preparing bis(hydroxymethyl)pyrrolopyrrole compounds of the formula wherein A1 and A2 are aryl radicals, by reacting a 1,4-diketopyrrolopyrrole with formaldehyde. The compound of formula (II) can be isolated or further reacted in a one pot synthesis to yield a compound of the formula wherein B1 and B2 are organic radicals.

专利号:US-6441174-B1
优先权日:1998-11-23
标题:Process for preparing bis(hydroxymethyl)perylenetetracarboximide
发明人：HENDI SHIVAKUMAR BASALINGAPPA
权利人:CIBA SC HOLDING AG
摘要:The invention is directed to a process for preparing a bis(hydroxymethyl)perylenetetracarboximide compound by reacting perylene-3,4,9,10-tetracarboximide with formaldehyde. The bis(hydroxymethyl)perylenetetracarboximide can be isolated or further reacted in a one pot synthesis to yield a compound of the formulawherein X1 and X2 are organic radicals.

专利号:US-4644010-A
优先权日:1982-09-28
标题:Certain β-oxo-α-carbamoylpyrrolepropionitriles
发明人：WALKER GORDON N
权利人:CIBA GEIGY CORP
摘要:1-Unsubstituted β-oxo-α-(phenylcarbamoyl)-β-pyrrolylpropionitriles, e.g. those of the formula ##STR1## wherein R 1 and R 2 =H or alkyl, and R 3 and R 4 =H, alkyl, alkoxy, OH, halogen or CF 3 , are analgesic, and antiarthritic agents. Their synthesis, pharmaceutical compositions thereof, and methods of treatment utilizing such compounds are included.