CAS: 576-83-0; 2,4,6-Trimethylbromobenzene

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CAS号108-67-8 均三甲苯 | CAS号1483-92-7 Disulfide,bis(2... | CAS号88-05-1 2,4,6-三甲基苯胺 | CAS号37055-29-1 2,4,6-trimethyl... | CAS号3453-83-6 2-甲基磺酰氯 | CAS号7726-95-6 溴素 | CAS号7697-37-2 硝酸 | CAS号7727-15-3 三溴化铝 | CAS号527-53-7 1,2,3,5-四甲基苯 | CAS号33667-80-0 2,4,6-三甲基二苯硫醚 | CAS号5599-27-9 DIMESITYLDICHLO... | CAS号313-56-4 2,2,2-三氟-2',4',... | CAS号3112-46-7 荚基化氧乙醛酸 | CAS号34688-71-6 2,4,6-三甲基苯乙腈 | CAS号144650-37-3 dibromodimesity... | CAS号108343-63-1 dimesityltin di... | CAS号144650-36-2 bromo-chloro-bi...

均三甲苯置于碘苯,对甲苯磺酸,间氯过氧苯甲酸,Lithium Bromide体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 1.0H,以85%的收率获得产物2-溴-1,3,5-三甲基苯
参考文献:催化性高价碘(iii)试剂对富电子芳族化合物的高效区域选择性单溴化反应
标题:催化性高价碘(iii)试剂对富电子芳族化合物的高效区域选择性单溴化反应
摘要:富电子的芳族化合物的有效和区域选择性单溴化报道,其中碘苯被用作与组合可回收催化剂米氯过苯甲酸作为氧化剂终端.室温下,在四氢呋喃中,富电子的芳族化合物与溴化锂的溴化速度很快,从而提供了具有非常好收率的区域选择性单溴化产物. 单溴-高价碘试剂-催化氧化.
DOI:10.1055/s-0030-1258350

专利信息

专利号:US-6355826-B1
优先权日:1997-09-17
标题:Synthesis of stable nitrile oxide compounds
发明人：PARKER DANE KENTON
权利人:GOODYEAR TIRE & RUBBER
摘要:This invention discloses a process for the synthesis of stable aryl nitrile oxides which comprises the sequential steps of (1) halomethylating a halomethyl group onto a substituted aromatic compounds wherein said halomethyl group is halomethylated onto a position that is ortho to at least one of the substituent groups on the substituted aromatic compound; (2) converting the ortho halomethylated-substituted aromatic compound into an ortho-substituted aromatic aldehyde by reacting the ortho halomethylated-substituted aromatic compound with a salt selected from the group consisting of sodium 2-nitropropane and potassium 2-nitropropane in a lower alcohol solvent; (3) converting the ortho-substituted aromatic aldehyde into an ortho-substituted aromatic; and (4) converting the ortho-substituted aromatic oxime into the ortho-substituted aryl nitrile oxide by reacting the ortho-substituted aromatic oxime with an aqueous sodium hypochlorite solution.

专利号:US-5428166-A
优先权日:1992-06-18
标 题 :Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs
发明人：COMINS DANIEL L
权利人:UNIV NORTH CAROLINA STATE
摘要:A method of making racemic DE ring intermediates for the synthesis of camptothecin and camptothecin analogs employing novel intermediates of Formula XX and XXI: ##STR1## as precursors to the DE ring intermediate. The present invention also provides camptothecin analog of Formula I-A ##STR2## wherein: Hal is a halogen is selected from the group consisting of F, Cl, and Br; n R may be loweralkyl; n R 1 may be H, loweralkyl, loweralkoxy, or halo; n R 2 , R 3 , R 4 , and R 5 may each independently be H, amino, hydroxy, loweralkyl, loweralkoxy, loweralkyl-thio, di(loweralkyl)amino, cyano, methylenedioxy, formyl, nitro, halo, trifluoromethyl, amninomethyl, azido, amido, hydrazino, or any of the twenty standard amino acids bonded to the A ring via the amino-nitrogen atom. n Additionally, novel compounds useful in the preparation of the compounds of Formula I-A are also provided.

专利号:US-2007197797-A1
优先权日:2005-12-30
标 题 :Compounds and methods for carbazole synthesis
发明人：HARRINGTON PETER J
权利人:HARRINGTON PETER J
摘要:Compounds having bi-cyclic structure comprising a partially unsaturated 6-carbon first cyclic moiety interconnected to a 6-carbon second cyclic moiety second via a divalent linking moiety are provided. The compounds can be used as intermediates compounds in methods for the synthesis of carbazoles and derviatives thereof, including carvedilol, and tricyclic alkylhydroxamates, which do not require Fischer indole synthetic steps. Methods of preparing the compounds having bi-cyclic structures are also provided.

专利号:US-2020398222-A1
优先权日:2019-06-14
标题 :Control of composite covalent organic framework by varying functional groups inside the pore
发明人：LI-OAKEY KATIE DONGMEI; HOBERG JOHN; PARKINSON BRUCE ALAN
权利人:UNIV WYOMING
摘要:An ordered functional nanoporous material (OFMN) composition includes a pore defined by a sidewall, the sidewall comprising N—C—N linkages therein. A process for synthesis of a reagent includes the reaction of a 6,7-diaminoquinoxaline having R groups with hexaketocyclohexane (HKH) octahydrate, where R is independently in each occurrence H, Cl, Br, I, C4H4S (thiophenyl), SO3−, CO2−, C≡CH, CHâ•?CH2, NH2, OH, C≡N, C1-C4 alkyl, (CH2)xCHâ•?CH2, or (CH2)yCHâ•?CH(CH2)z where x or (y+z) is an integer of 0 to 4 inclusive, (CH2)jCH≡CH, or (CH2)kCH≡C(CH2)r where j or (k+r) 0 to 4 inclusive. A process of degasification that includes extracting a gas from a mixture by exposing the mixture to an OFNM to selectively pass the gas therethrough. A process of dehydrogenation includes exposing an aliphatically unsaturated feedstock to platinum modified OFNM under conditions to form hydrogen and selectively passing the hydrogen through the platinum modified OFNM.

专利号:US-11897827-B1
优先权日:2022-11-22
标 题 :Carbon isotope exchange mediated by vanadium complexes
发明人：BUKHRYAKOV KONSTANTIN
权利人:BUKHRYAKOV KONSTANTIN; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, carbon isotope exchange (CIE) on target bioactive molecules. Methods that allow CIE directly on drug candidates are of great importance to chemistry, biology, and medicine. Especially valuable are catalytic procedures that rely on a limited collection of available labeled materials. The instant method comprises converting a methyl group to terminal â•?CH2 utilizing transfer dehydrogenation catalysts to enable V-based olefin metathesis, followed by a hydrogenation step. The one-pot strategy allows the formal methylation/demethylation sequence and can be applied to an assortment of alkyl-containing compounds.

专利号:WO-2022256660-A1
优先权日:2021-06-04
标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
发明人：HARRISON CRISTIAN
权利人:VERTEX PHARMA
摘要:Provided in this application is a process for making Compound I (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. Processes for making various intermediate products, and suitable salts thereof, are also provided.