CAS: 566-48-3; Formestane

上下游产品

Androstenedione 4ξ,5-dihydroxy-5ξ-androstane-3,17-dione acetic acid 4,5-epoxyandrostane-3,17-dione4-methoxyandrost-4-ene-3,17-dione 4-phenoxy-4-androstene-3,17-dione 4-acetoxyandrostenedione 4-(O-acetylsalicyloxy)androst-4-en-3,17-dione

3-Hydroxy-5β-Androst-2-Ene-4,17-Dione置于sodium体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,以80%的收率获得产物福美司坦
参考文献:福美斯坦 5β-环氧化物前体异常环裂解的 X 射线和氘标记研究
标题:福美斯坦 5β-环氧化物前体异常环裂解的 X 射线和氘标记研究
摘要:抗肿瘤类固醇福美烷 (4-Oha) 5 的新聚合合成已从 5 α-和 5 β-Androst-3-En-17-One 1A 和 1B 的易于获得的差向异构混合物进行,以尝试提高产量改进.对 5 个 α-和 5 个 β-差向异构体 1A 和 1B 应用两步氧化路线,然后进行碱催化异构化,无论是作为混合物还是分开,得到标题化合物 5.从差向异构体 1A 获得了一个有效的过程制备所需的芳香酶抑制剂福美斯坦.差向异构体 1B 导致了相同化合物 5 的形成.此外,1B 也被转化为 5β-羟基雄甾烷-3,17-二酮 12 和雄甾醇-4-烯-3,17-二酮 13,揭示了出乎意料的反应性3 测试版,4 β-Epoxy-5 β-Androstan-17-One 中间体 6 在与过甲酸的第一个氧化步骤中由 1B 形成.环氧化物 6 的裂解导致了反双轴和反赤道 Vic-二醇 7 和 8 以及 1,3-二醇 9.通过
DOI:10.1016/s0039-128X(01)00164-7

专利信息

专利号:WO-2009044115-A1
优先权日:2007-09-29
标 题:Endocrine disruptors
发明人：WARING ROSEMARY HOPE; RAMSDEN DAVID BOYER
权利人:UNIV BIRMINGHAM; WARING ROSEMARY HOPE; RAMSDEN DAVID BOYER
摘要:A method is provided for assessing the potential of one or more test compounds to disrupt the endocrine system. The method comprises measuring the effect of the test compound(s) on hormone sulphation, oestrogen synthesis, and thyroid hormone and/or growth hormone function. These tests may be carried out sequentially or in parallel. Also provided is a test kit for assessing the endocrine disruption potential of a compound. The kit comprises means for assessing the effect of a compound on hormone sulphation, oestrogen synthesis, and thyroid hormone and/or growth hormone function. The kit may also contain comprise one or more optional control test compounds.