CAS: 5396-38-3; 1-(Tert-Butyl)-4-Methoxybenzene

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4132-48-3 33733-83-4 5351-07-5

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CAS号98-54-4 对叔丁基苯酚 | CAS号74-88-4 碘甲烷 | CAS号4637-24-5 N,N-二甲基甲酰胺二甲基缩醛 | CAS号77-78-1 硫酸二甲酯 | CAS号67-56-1 甲醇 | CAS号3972-56-3 1-叔丁基-4-氯苯 | CAS号3001-72-7 1,5-二氮杂双环[4.3.0... | CAS号616-38-6 碳酸二甲酯 | CAS号507-20-0 氯代叔丁烷 | CAS号100-66-3 苯甲醚 | CAS号98-54-4 对叔丁基苯酚 | CAS号108-95-2 苯酚 | CAS号51-28-5 2,4-二硝基酚 | CAS号85943-26-6 5-(叔丁基)-2-甲氧基苯甲醛 | CAS号77055-30-2 4-叔丁基-2,6-二硝基苯甲醚 | CAS号132098-47-6 4-tert-butyl-2-... | CAS号100-17-4 4-硝基苯甲醚 | CAS号91247-60-8 Benzene, 4-(1,1... | CAS号2944-48-1 Benzene,1-(1,1-... | CAS号33733-83-4 1-叔丁基-3-甲氧基苯

📜在 三氟乙酸,间氯过氧苯甲酸体系中,用 四氢呋喃,甲苯,二氯甲烷 作为反应溶剂,化学反应 8.0H,以31 Mg的收率获得产物4-叔丁基茴香醚
参考文献:通过钛环丁烷的质子分解进行位点特异性烯烃氢甲基化
标题:通过钛环丁烷的质子分解进行位点特异性烯烃氢甲基化
摘要:甲基在生物活性分子中普遍存在.因此,将这种烷基片段引入多官能结构的新策略引起了人们的极大兴趣.考虑到这一目标,报告了一种烯烃马尔可夫尼科夫氢甲基化的直接方法.该方法利用了cp 2 Ti(μ-Cl)(μ-Ch 2)Alme 2 (Tebbe试剂)中的钛亚甲基与未活化的烯烃之间的简并复分解反应.所得环丁烷钛的原位质子解作用以化学,区域和位点选择性方式实现氢甲基化.该方法的广泛实用性在一系列含有侧醇,醚,酰胺,氨基甲酸酯和碱性胺的单取代和二取代烯烃中得到了证明.
DOI:10.1002/anie.202103278

专利信息

专利号:US-11661406-B2
优先权日:2018-08-13
标 题 :Method for producing intermediate useful for synthesis of SGLT inhibitor
发明人：LI QING RI; YOON HEE KYOON
权利人:DAEWOONG PHARMACEUTICAL CO LTD
摘要:A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-11247977-B2
优先权日:2018-06-22
标题 :Compound and use thereof in synthesis of brivaracetam intermediate and crude drug
发明人：FENG YAN; WANG RUYONG; YE YIZHANG; ZHANG FENGSEN; GONG XUAN; WANG ZHONGHONG; KANG XINSHAN
权利人:FUJIAN HAIXI PHARMACEUTICALS CO LTD
摘要:The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2016317682-A1
优先权日:2015-04-30
标题:PREPARATION OF Ag18F AND ITS USE IN THE SYNTHESIS OF PET RADIOTRACERS
发明人：SCOTT PETER J H; BROOKS ALLEN F; ICHIISHI NAOKO; SANFORD MELANIE S
权利人:UNIV MICHIGAN REGENTS; THE REGENTS OFTHE UNIV OF MICHIGAN
摘要:Copper-catalyzed radiofluorination of aryl iodides using Ag 18 F, methods of preparing Ag 18 F, and compounds obtained by copper-catalyzed radiofluorination of aryl iodides using Ag 18 F are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed.

专利号:US-11365211-B2
优先权日:2018-02-01
标 题 :Stereoselective synthesis and process for the manufacturing of 2′-deoxynucleosides
发明人：ZHANG LIANHAO; VISHNUVAJJALA BABURAO; MORRIS JOEL; BAHDE ROBERT; DENYSENKO SERGIY M; LOPEZ OMAR DIEGO; WISHKA DONN GREGORY
权利人:THE USA AS REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVICES; ALCHEM LABORATORIES CORP; US HEALTH
摘要:Methods for stereoselective synthesis and manufacturing of 2′-deoxynucleosides, such as 2′-ribonucleosides, are disclosed. In some embodiments, the 2′-deoxynucleoside is a β-anomer of a 2′-deoxynucleoside having a 3′ α hydroxyl, 4′ β hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4′-thio-2′-deoxycytidine (T-dCyd) and 5-aza-4′-thio-2′-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).