CAS: 4712-55-4; Diphenyl Phosphite

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CAS号2310-89-6 hydroxy-oxo-phe... | CAS号108-95-2 苯酚 | CAS号101-02-0 亚磷酸三苯酯 | CAS号54921-72-1 phenyl H-phosph... | CAS号5382-00-3 Diphenyl phosph... | CAS号598-02-7 磷酸二乙酯 | CAS号7647-01-0 盐酸 | CAS号367508-01-8 (N-甲氧基-N-甲氨基甲酰甲... | CAS号19758-98-6 [(methoxyamino)... | CAS号2310-89-6 hydroxy-oxo-phe... | CAS号20442-56-2 Phosphonic acid... | CAS号101-02-0 亚磷酸三苯酯 | CAS号19348-92-6 N-[diphenoxypho... | CAS号19047-85-9 双十二烃基磷酸 | CAS号19348-89-1 N-(diphenoxypho... | CAS号2752-95-6 磷酸丁基二苯酯 | CAS号3049-24-9 苯膦酸二苯酯

亚磷酸三苯酯置于三氟甲磺酸,水体系中,用91%的收率获得产物亚磷酸二苯酯
参考文献:水决定了产物:意外的布朗斯台德酸催化p(iii)酯的po-R裂解,选择性地产生p(o)-H和p(o)-R化合物
标题:水决定了产物:意外的布朗斯台德酸催化p(iii)酯的po-R裂解,选择性地产生p(o)-H和p(o)-R化合物
摘要:发现水能够确定布朗斯台德酸催化的亚磷酸三烷基酯的c-O裂解反应的选择性:与水一起,该反应在室温下迅速发生,从而定量获得h-膦酸酯的收率.在不加水的情况下,该反应选择性地以高收率提供了烷基膦酸酯,为著名的michaelis-Arbuzov反应提供了一种新型的无卤化物替代方案.该方法是通用的,因为它可以很容易地扩展到亚膦酸酯和次膦酸酯以及大规模的反应,而催化剂的负载却低得多,从而能够简单,有效和实用地制备相应的有机磷化合物.
DOI:10.1039/c9Gc01254K

专利信息

专利号:WO-2016005407-A1
优先权日:2014-07-07
标 题:One-pot synthesis of squaramides
发明人：MÃ?RQUEZ LÓPEZ MARÃ?A EUGENIA; ALEGRE REQUENA JUAN VICENTE; PÉREZ HERRERA RAQUEL
权利人:UNIV ZARAGOZA; CONSEJO SUPERIOR INVESTIGACION
摘要:The present invention refers to the first one-pot synthesis of squaramides. The one-pot synthesis of squaramides described herein is an easy and straightforward procedure to obtain squaramide derivatives which saves energy, avoids time consuming purification steps, reduces costs and provides better yields as compared with those squaramides obtained through the traditional 'stop-and-go' approach. Moreover, the authors of the present invention herein demonstrate the efficiency of this one-pot process with the synthesis of three biologically active structures, improving in most of the cases the results of the previous stepwise syntheses.

专利号:US-6909010-B2
优先权日:2001-04-11
标题:Facile synthesis of symmetric esters of alkylenebisphosphonic acids
发明人：HERLINGER ALBERT W; STEPINSKI DOMINIQUE C
权利人:UNIV LOYOLA CHICAGO
摘要:A facile synthesis of symmetric esters of C 1 -C 10 alkylenebisphopsphonic acids is disclosed in which a C 1 -C 10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1H-tetrazole and a base in an aprotic solvent to form a first reaction mixture. The first reaction mixture is maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(chloro ester phosphonate) that is reacted under basic conditions with an excess of a hydroxylated compound to form a second reaction mixture that is itself maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(ester phosphonate) partial ester, homoleptic tetraester or mixed tetraester. The material so formed can be recovered or used as is.

专利号:US-9416113-B2
优先权日:2011-02-10
标 题:Formation of N-protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine
发明人：FREEMAN JOHN J; STAMPER ADRIENNE; HEITMANN MELISSA
权利人:MANNKIND CORP; MANNKIND CORP
摘要:The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular improved methods for the cyclocondensation and purification of N-protected 3,6-(aminoalkyl)-2,5-diketopiperazines from N-protected amino acids. Disclosed embodiments describe methods for the synthesis of 3,6-bis-[N-protected aminoalkyl]-2,5-diketopiperazine comprising heating a mixture of an amino acid in the presence of a catalyst in an organic solvent. The catalyst is selected from the group comprising sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl phosphonic acid and phosphorous pentoxide among others. The solvent is selected from the group comprising: dimethylacetamide, N-methyl-2-pyrrolidone, diglyme, ethyl glyme, proglyme, ethyldiglyme, m-cresol, p-cresol, o-cresol, xylenes, ethylene glycol and phenol among others.

专利号:WO-2013117440-A1
优先权日:2012-02-09
标 题 :Synthesis of water-soluble phosphine oxides by pd/c-catalyzed p-c coupling in water
发明人：RANOCCHIARI MARCO; RUMMELT STEPHAN; VAN BOKHOVEN JEROEN A
权利人:SCHERRER INST PAUL
摘要:Cross-coupling between diphenylphosphine oxide and halogenated benzoic acids catalyzed by Pd/C in water is a green, simple and fast protocol to obtain water-soluble tertiary phosphine oxides without the addition of ligands and additives. Low reaction times, microwave irradiation, and high substrate scope make this method general and excellent for lab- and large-scale synthesis without the need to use organic solvents for neither reaction nor workup.

专利号:US-10899878-B2
优先权日:2017-04-06
标 题:Phosphorus-containing caprolactone monomers for synthesis of flame retardant polycaprolactones
发明人：CAMPBELL ERIC J; CZAPLEWSKI SARAH K; KOBILKA BRANDON M; WERTZ JASON T
权利人:IBM
摘要:A process of forming a flame retardant monomer includes forming a hydroxyl-functionalized caprolactone molecule, and reacting the hydroxyl-functionalized with a phosphorus-containing flame retardant molecule to form a flame retardant-functionalized caprolactone monomer. A flame retardant monomer includes at least one moiety derived from a hydroxyl-functionalized caprolactone molecule and at least one phosphorus-containing flame retardant moiety. A flame retardant polymer includes at least two flame retardant monomer repeat units, each flame retardant monomer repeat unit including at least one moiety derived from a hydroxyl-functionalized caprolactone molecule and at least one phosphorus-containing flame retardant moiety.

专利号:WO-2025010390-A1
优先权日:2023-07-05
标题 :Synthesis of pyruvate kinase activators
发明人：FANDRICK DANIEL; LEUNG CHUN YUEN; CRANE SHELDON; LACHANCE NICOLAS; LE ROUX ANTOINE; PATEL JIGNESH; VALAMALE ASHALATHA
权利人:AGIOS PHARMACEUTICALS INC
摘要:Provided herein are methods for preparing activators of Pyruvate Kinase (PK) or a salt or a hydrate thereof.