CAS: 402-44-8; 1-Fluoro-4-(Trifluoromethyl)Benzene

上下游产品

CAS号128796-39-4 4-(三氟甲基)苯硼酸 | CAS号188748-63-2 三乙氧基[4-(三氟甲基)苯基]硅烷 | CAS号402-54-0 4-硝基三氟甲苯 | CAS号1765-93-1 4-氟苯硼酸 | CAS号2926-29-6 三氟代甲烷亚磺酸钠 | CAS号455-13-0 4-碘三氟甲苯 | CAS号455-14-1 4-氨基三氟甲苯 | CAS号402-42-6 4-氟三氯苄 | CAS号352-32-9 对氟甲苯 | CAS号349-65-5 2-甲氧基-5-三氟甲基苯胺 | CAS号352535-96-7 2-氟-5-(三氟甲基)苯硼酸 | CAS号367-86-2 3-硝基-4-氟三氟甲苯 | CAS号394-25-2 4-甲氧基-3-硝基三氟甲苯 | CAS号39634-42-9 4-(4-(三氟甲基)苯氧基苯酚 | CAS号535-52-4 2-氟-5-三氟甲基苯胺 | CAS号352-32-9 对氟甲苯 | CAS号459-47-2 1-乙基-4-氟苯 | CAS号403-39-4 4-氟异丙基苯 | CAS号402-42-6 4-氟三氯苄

4-硝基三氟甲苯置于四丁基氟化铵体系中,用 二甲基亚砜 作为反应溶剂,化学反应 2.0H,反应生成 4-氟三氟甲苯
参考文献:室温亲核芳族氟化:实验和理论研究.
标题:室温亲核芳族氟化:实验和理论研究.
摘要:
DOI:10.1002/anie.200504555

专利信息

专利号:US-6846957-B2
优先权日:2002-11-22
标题 :Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor
发明人：ZELENIN ALEXANDER
权利人:UNIV TEXAS
摘要:The present invention concerns a method of synthesizing fluoxetine hydrochloride. The method includes the synthesis of 3-methylamino-1-phenyl-1-propanol by reduction of 1-phenyl-3-methylamino-2-propen-1-one with sodium borohydride and acetic acid.

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-2023399302-A1
优先权日:2020-10-29
标题:Process for the preparation of heteroaryl-substituted sulfur(vi) compounds
发明人：LOPCHUK JUSTIN M; SHULTZ ZACHARY P; SCATTOLIN THOMAS
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.

专利号:WO-0021917-A1
优先权日:1998-10-13
标题 :Pharmaceutical intermediate for the synthesis of fluoxetine and a process for the preparation thereof
发明人：REITER JOZSEFNE; SIMIG GYULA; MEZEI TIBOR; IMRE JANOS; VERECZKEYNE DONATH GYOERGYI; NAGY KALMAN; NEMETH NORBERT; SZABO TIBOR
权利人:EGYT GYOGYSZERVEGYESZETI GYAR; REITER JOZSEFNE; SIMIG GYULA; MEZEI TIBOR; IMRE JANOS; VERECZKEYNE DONATH GYOERGYI; NAGY KALMAN; NEMETH NORBERT; SZABO TIBOR
摘要:The invention relates to N,N-dimethyl-{3-phenyl-3-[(4-trifluoromethyl)-phenoxy]-propyl-amine}-p-toluenesulfonate of Formula (I) and an improved process for the preparation thereof. The new compound of Formula (I) is a valuable pharmaceutical intermediate useful in the preparation of the antidepressant having the generic name fluoxetine.

专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-5998627-A
优先权日:1997-08-04
标题 :Preparation and uses of hydrocarbylnitrones
发明人：THERIOT KEVIN J
权利人:ALBEMARLE CORP
摘要:Nitrones are produced by reaction of primary amine with aldehyde or ketone, in the presence of a transition metal-containing oxidation catalyst, and a peroxidic compound. The nitrone can then be reacted with a vinylaromatic compound to produce a 2-hydrocarbyl-5-arylisoxazolidine. Both such reactions can be conducted concurrently by including the vinylaromatic compound in the initial reaction mixture. Hydrogenation of the 2-hydrocarbyl-5-arylisoxazolidine, e.g., using hydrogen and a palladium-carbon catalyst, forms an N-hydrocarbyl-3-aryl-3-hydroxypropylamine. Such reactions enable, inter alia, synthesis of the racemic hydrochloride salt of N-methyl-3-phenyl-3-[4-trifluoromethyl)phenoxy]-propylamine, known generically as fluoxetine hydrochloride, a widely used antidepressant.