CAS: 3754-19-6; Ambuside

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CAS号5436-21-5 4,4-二甲氧基-2-丁酮 | CAS号3921-09-3 2-Allylsulfamoy...

📜4,4-二甲氧基-2-丁酮,2-Allylsulfamoyl-5-Chlor-4-Sulfamoyl-Anilin 在 盐酸体系中,获得 Ambuside
参考文献:利尿剂.6-取代的3-酮烷基-3,4-二氢-2H-1,2,4-苯并噻二嗪1,1-二氧化物和相关的苯胺,肟和氢酮.
标题:利尿剂.6-取代的3-酮烷基-3,4-二氢-2H-1,2,4-苯并噻二嗪1,1-二氧化物和相关的苯胺,肟和氢酮.
摘要:
Doi:10.1021/Jm00325A018

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-6972330-B2
优先权日:1996-02-13
标题:Chemical synthesis of methoxy nucleosides
发明人：BEIGELMAN LEONID; HAEBERLI PETER; KARPEISKY ALEXANDER; SWEEDLER DAVID
权利人:SIRNA THERAPEUTICS INC
摘要:Process for chemical synthesis of methoxy nucleosides.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-4461726-A
优先权日:1982-05-17
标题 :Desulfurization of penicillins to prepare azetidinones
发明人：WEI CHUNG-CHEN; WEIGELE MANFRED
权利人:HOFFMANN LA ROCHE
摘要:A process for the Raney nickel desulfurization of penicillins is described. In the process of the invention, amino penicillanic acid or derivatives thereof are reacted with Raney nickel under controlled conditions of temperature and time to yield azetidinones which are useful as intermediates for the synthesis of monocyclic beta-lactam antibiotics.

专利号:US-5962675-A
优先权日:1996-02-13
标 题:Chemical syntheses of 2'-O-methoxy purine nucleosides
发明人：BEIGELMAN LEONID; SWEEDLER DAVID; HAEBERLI PETER; KARPEISKY ALEXANDER
权利人:RIBOZYME PHARM INC
摘要:Several processes for the chemical synthesis of 2'-O-methoxy purine nucleosides are herein disclosed.

专利号:WO-9106589-A1
优先权日:1989-11-03
标题 :New anti-hiv compounds belonging to aurintricarboxylic acid
发明人：HAUGWITZ RUDIGER D; NARAYANAN VENKATACHALA
权利人:US COMMERCE; PURDUE RESEARCH FOUNDATION
摘要:The invention relates to the synthesis of compounds with anti-retroviral activity. The synthesis of substantially pure aurintricarboxylic acid monomer and structurally defined polymers, analogs and derivatives thereof, is described. The compounds are shown to have potent anti-retroviral activity, particularly against HIV-1.