CAS: 32539-85-8; Cyclopentadecanolide

英文名称Cyclopentadecanolide
中文名称环十五内酯
CAS编号32539-85-8
MFCD编号:MFCD30719664
FDA UNII编号:4N2UX27F2A
分子式:C15H28O2
分子量:240.38
产品CID: 1316364
产品分类香精与香料 → 合成香料 → 麝香和大环类香料

相似结构搜索
产品信息参考;
InChIKey: LVECZGHBXXYWBO-UHFFFAOYNA-N
1S/C15H28O2/c1-14-12-10-8-6-4-2-3-5-7-9-11-13-15(16)17-14/h14H,2-13H2,1H3…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数0.0

物理性质

熔点34-38 °C(文献)
沸点137 °C2 mm Hg(文献)
闪点141.1 °C
密度0.878g/cm3
PSA:26.3
LogP:4.6129
折射率1.432
蒸汽压8.87E-05 mmHg at 25 °C
产品应用环十五内酯(32539-85-8)的用途:本品可用于生产香精,香料和化妆品.
性质描述环十五内酯(32539-85-8)的性状:稠厚的油状液体.有琥珀和麝香的气味.在真空中升华,成针状结晶.溶于乙醇.相对密度0.9549.熔点32°C.沸点176°C(2.00kPa).折光率1.4708.

上下游产品

CAS号3344-77-2 12-溴-1-十二烷醇 | CAS号73367-80-3 12-溴十二烷酸 | CAS号81819-08-1 13-bromo-2-hydr... | CAS号81819-07-0 12-bromododecanal | CAS号78812-89-2 2-(13-hydroxyte...

合成工艺路线路线简述

12-溴十二烷酸置于celite,Sensitox 盐酸,正丁基锂,硼烷,氧气,对甲苯磺酸,二异丙胺,Pyridinium Chlorochromate,Sodium Iodide体系中,用四氢呋喃,甲醇,乙醚,正己烷,二氯甲烷用作溶剂,化学反应 73.0H,反应生成环十五内酯
参考文献:恶唑的光氧化作用活化的羧酸盐:应用于累西腓利特,卡维拉林和其他大环内酯类化合物的合成
标题:恶唑的光氧化作用活化的羧酸盐:应用于累西腓利特,卡维拉林和其他大环内酯类化合物的合成
摘要:恶唑可用作活化羧酸的掩蔽形式,因为它们在与单线态氧反应时容易形成三酰胺.对于2-烷基-4,5-二苯基恶唑,在光氧化作用下形成的三酰胺在衍生自2-恶唑位置的酰基羰基上经历选择性的亲核攻击.使用2-(ω-羟烷基)-4,5-二苯基恶唑作为底物,氧化-酰化序列可用于合成大环内酯类化合物,包括(+/-)-瑞奇奥利德和(+/-)-二-0-甲基曲维林.
Doi:10.1016/s0040-4020(01)93281-8

海关参考信息

2905122000-异丙醇
2909110000-乙醚
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-5936100-A
优先权日:1996-12-16
标题:Synthesis of functionalized macrocycles by ring closing metathesis
发明人：FUERSTNER ALOIS; LANGEMANN KLAUS; KINDLER NICOLE
权利人:STUDIENGESELLSCHAFT KOHLE MBH
摘要:The invention concerns an improved process for the preparation of macrocyclic products with 12 or more ring atoms containing one or more polar functional groups on the ring and/or one or more heteroatoms within the ring by ring closing metathesis (RCM) of suitably substituted diene precursors even if the substrates are devoid of any kind of conformational preorganization. Metal carbene complexes of Ru, Mo, W, Re, Os, which are tolerant towards the respective functional group and can either be isolated or prepared in situ are used as catalysts or catalyst precursors. Preferred catalysts or catalyst precursors are ruthenium complexes of the general type XX1LL1Ru=CRR1, wherein X, X1=halogen, L, L1=trialkylphosphine, R, R1=H, Ph, CH=CPh2 denote the most preferred embodiment. The process can be applied to the synthesis of olfactory compounds, perfumary ingredients, pheromones, crown ethers, antibiotics and pharmaceuticals for human and veterinary medicine.

专利号:FR-1002688-A
优先权日:1948-12-01
标题 :Process for the preparation by synthesis of pentadecanolide

专利号:JP-H10175882-A
优先权日:1996-12-13
标题 :Synthesis of Functionalized Macrocycles by Ring Closing Metathesis

专利号:JP-H067173-A
优先权日:1991-03-29
标题:DNA fragment containing a lipase-producing gene capable of lactone synthesis