CAS: 3014-80-0; H-Val-Nh2.Hcl

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(R)-(R)-2-((Tert-Butoxycarbonyl)Amino)-3-Methylbutanoic (Ethyl Carbonic) Anhydride置于盐酸,氨体系中,用 水,乙酸乙酯 作为反应溶剂,化学反应生成 L-缬氨酰胺盐酸盐
参考文献:[2,3]烯丙基硒酰亚胺的正向重排:肽,拟肽和n-芳基乙烯基甘氨酸合成策略
标题:[2,3]烯丙基硒酰亚胺的正向重排:肽,拟肽和n-芳基乙烯基甘氨酸合成策略
摘要:Ncs介导的对映体富集的烯丙基硒化物的胺化/ [2,3]-σ重排的范围已得到扩展,可以提供三种新产品类别.使用ñ-保护的氨基酸酰胺提供用于访问含有非天然乙烯基甘氨酸氨基酸残基的肽链的新策略.还报道了使用氨基酸酯,其允许非对映选择性地合成n,N-二羧甲基胺,这是许多药物中发现的基序.此外,使用多种n-芳族和n-杂芳族胺可形成对映体富集的n-芳基氨基酸,一种在许多合成和生物学上令人感兴趣的化合物中发现的基序.
DOI:10.1021/jo500341E

专利信息

专利号:US-6495693-B2
优先权日:1996-11-22
标题:N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; FOLMER BEVERLY K; JOHN VARGHESE; LATIMER LEE H; NISSEN JEFFREY S; PORTER WARREN J; THORSETT EUGENE D; WU JING
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-3190917-A
优先权日:1961-06-08
标 题 :Synthesis of alpha-amino acid amide hydrohalides
发明人：JOHNSON HERBERT E; CROSBY DONALD G
权利人:UNION CARBIDE CORP

专利号:CH-422814-A
优先权日:1961-06-08
标 题 :Process for the synthesis of alpha-amino acid amide halohydrates

专利号:US-5663149-A
优先权日:1994-12-13
标 题:Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
发明人：PETTIT GEORGE R; SRIRANGAM JAYARAM K; KANTOCI DARKO
权利人:UNIV ARIZONA
摘要:The synthesis and elucidation of nineteen heterocyclic or halophenyl amideerivatives of dolastatin 10 are disclosed. These compounds and the methods of producing those compounds offer demonstrated significant in vitro activity against several human cancer cell lines. These compounds and the methods of producing those compounds offer a commercially viable alternative to natural and synthetic dolastatin 10.

专利号:US-6096782-A
优先权日:1996-11-22
标 题:N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

专利号:CA-2270876-A1
优先权日:1996-11-22
标 题:N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds