CAS: 29781-80-4; (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(Octyloxy)Tetrahydro-2H-Pyran-3,4,5-Triol

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CAS号2280-44-6 D-glucopyranose | CAS号111-87-5 正辛醇 | CAS号492-62-6 α-D-葡萄糖 | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号604-69-3 β-D-葡萄糖五乙酸酯 | CAS号9004-34-6 微晶纤维素 | CAS号572-09-8 2,3,4,6-四乙酰氧基-a... | CAS号80-69-3 亚酒石酸 | CAS号147-73-9 內消旋酒石酸 | CAS号87-69-4 酒石酸 | CAS号526-95-4 葡萄糖酸 | CAS号87-73-0 葡萄糖二酸 | CAS号144-62-7 草酸 | CAS号124-07-2 辛酸

📜辛基-D-吡喃葡萄糖苷置于吡啶,Sodium Methylate体系中,用 甲醇 用作溶剂,化学反应生成正辛基 α-D-葡萄糖苷
参考文献:探索超分子环境中糖构型的含义:通过itc和NMR光谱比较六个辛基糖苷胶束†
标题:探索超分子环境中糖构型的含义:通过itc和NMR光谱比较六个辛基糖苷胶束†
摘要:合成了一系列甘露糖基-半乳糖基和葡萄糖基辛基α-和β-糖苷,并将其用于水中均胶束和杂胶束的形成.临界胶束浓度(cmc),消解的热力学量以及糖胶束的流体力学半径通过等温滴定量热法(itc)和扩散NMR研究确定.这项工作的目的是确定对于相应糖苷的超分子特征,端基异构体构型以及在糖环上差向异构化的重要性.提出了新的糖苷结构预测,以促进这方面的结构-性质关系的解释.
Doi:10.1039/c4Md00122B

专利信息

专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人：KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-2006211083-A1
优先权日:2005-01-21
标题:Products and processes for in vitro synthesis of biomolecules
发明人：KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
权利人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
摘要:Provided herein are products and processes for efficiently synthesizing biomolecules in vitro using cell-free extracts derived from mammalian cells and insect cells. In an embodiment, provided is a process for preparing a cell-free extract from insect cells and mammalian cells that efficiently synthesizes post-translationally modified target proteins (e.g., glycosylated target proteins). In some embodiments, a ribonucleic acid is synthesized in vitro that comprises a cap, a 5′ untranslated region comprising an 18S rRNA binding ribonucleotide sequence, and a target ribonucleotide sequence. It has been determined that such ribonucleic acids result in efficient in vitro synthesis of a target protein using cell-free extracts derived from non-rabbit mammalian cells and insect cells.

专利号:US-4739043-A
优先权日:1984-07-19
标题 :Method for the synthesis of alkyl, cycloalkyl or alcenyl aldosides or polyaldosides
发明人：DEFAYE JACQUES; WONG EMILE; PEDERSEN CHRISTIAN; CHEDIN JEAN; BOUCHU ALAIN
权利人:BEGHIN SAY SA
摘要:PCT No. PCT/FR85/00197 Sec. 371 Date Apr. 18, 1986 Sec. 102(e) Date Apr. 18, 1986 PCT Filed Jul. 18, 1985 PCT Pub. No. WO86/00906 PCT Pub. Date Feb. 13, 1986.The process comprises the action of a saturated aliphatic or cycloaliphatic alcohol or an aliphatic or cycloaliphatic alcohol comprising a double ethylenic bound not situated in alpha of the hydroxyl group with an aldose, aldoside or polyaldoside in the solvent and reactant formed by the hydrogen fluoride. Application to the synthesis of surfactants or as additives for rigidifying polyurethane foams.

专利号:US-2001049117-A1
优先权日:1998-08-20
标 题 :Analogs of udp-murnac peptides, assays, kits and related methods of their use
发明人：AXELROD HELENA R; BRANSTROM ARTHUR A
摘要:General compositions and methods for detecting Lipid I, Lipid II and peptidoglycan synthesis is disclosed. A method of screening for potential antibacterial agents is provided which requires bacterial membrane preparations or enriched enzyme preparations including at least one bacterial enzyme involved in the synthesis of Lipid I from UDP-MurNAc pentapeptide and undecaprenyl phosphate, at least one bacterial enzyme involved in the synthesis of Lipid II from Lipid I and UDP-GlcNAc and one or more bacterial enzymes involved in the further processing of Lipid II toward the downstream synthesis of peptidoglycan. The methods disclosed herein further provides a labeled UDP-MurNAc-peptide capable of serving as a substrate for a bacterial enzyme involved in the synthesis of Lipid I and a labeled UDP-GlcNAc capable of serving as a substrate for a bacterial enzyme involved in the synthesis of Lipid II. Conditions for further processing of Lipid II toward the downstream synthesis of peptidoglycan are also discribed.

专利号:US-6121430-A
优先权日:1998-12-28
标 题 :Regiospecific synthesis of glucose-based surfactants
发明人：LINHARDT ROBERT J; BAZIN HELENE G
权利人:UNIV IOWA RES FOUND
摘要:New glucose-based surfactants and methods of their synthesis are described. The surfactants are synthesized through the preparation of an intermediate glucose 4,6-cyclic sulfate. The surfactants are economical to prepare and have excellent surface-active properties.