CAS: 26538-44-3; (7R,11S)-7,15,17-Trihydroxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),15,17-Trien-13-One

上下游产品

CAS号17924-92-4 玉米赤霉烯酮 | CAS号106315-76-8 (3S,7R)-14,16-d... | CAS号36455-72-8 ALPHA-玉米赤霉烯醇 | CAS号34297-69-3 2-[10(S)-Hydrox... | CAS号325142-22-1 (3S,7R)-7,14,16... | CAS号37786-44-0 (3S)-14,16-dihy...

玉米烯酮置于sodium Tetrahydroborate,5 Mol% Pd/c,氢气体系中,用 甲醇,乙醇 用作溶剂,化学反应 3.0H,反应生成折仑诺
参考文献:半合成玉米赤霉烯酮类似物的合成和细胞毒活性
标题:半合成玉米赤霉烯酮类似物的合成和细胞毒活性
摘要:玉米赤霉烯酮是具有多种生物活性的β-间苯二酸大环内酯.本文中,我们报道了34种玉米赤霉烯酮类似物的合成及其对人口腔表皮样癌(kb)和人乳腺腺癌(mcf-7)细胞以及非癌性vero细胞的杀伤活性.一些玉米赤霉烯酮类似物对两种癌细胞显示出适度增强的细胞毒活性.我们发现了潜在的先导化合物,对vero细胞的细胞毒性降低或没有.初步的结构-活性关系研究表明,玉米赤霉烯酮核心1'和2'位置的双键对于这两种细胞系的细胞毒活性均至关重要.此外,对于玉米赤霉烯醇类似物,C-2处未保护的羟基和c-4处的烷氧基取代基在两种细胞系的细胞毒性作用中均起关键作用.
Doi:10.1016/j.Bmcl.2016.06.007

专利信息

专利号:US-7553979-B2
优先权日:2001-11-09
标题:HSP90-inhibiting zearalanol compounds and methods of producing and using same
发明人：KASIBHATLA SRINIVAS R; LE BRAZIDEC JEAN-YVES; MCHUGH SEAN KONRAD; BOEHM MARCUS F
权利人:CONFORMA THERAPEUTICS CORP
摘要:Zearalanol compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various disorders. Methods of synthesis and use of such compounds are also described and claimed.

专利号:WO-2012131010-A1
优先权日:2011-03-29
标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents

专利号:EP-2691372-A1
优先权日:2011-03-29
标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.