CAS: 262423-77-8; 2,4-Dichloronicotinc Acid

相似化合物

134031-24-6 180995-12-4 442903-28-8

上下游产品

CAS号26452-80-2 2,4-二氯吡啶 | CAS号124-38-9 二氧化碳 | CAS号109-09-1 2-氯吡啶 | CAS号153034-86-7 2-氯-4-碘吡啶 | CAS号78607-36-0 2-氯-3-碘吡啶 | CAS号442903-28-8 2,4-二氯烟酸甲酯 | CAS号38025-90-0 2-氯-6-羟基烟酸

2,4-二氯吡啶置于lithium Diisopropyl Amide,二氧化碳,盐酸,氢氧化钾,水体系中,用 四氢呋喃,正庚烷,苯 用作溶剂,化学反应 2.0H,以70%的收率获得2,4-二氯烟酸
参考文献:Novel Kinase Inhibitors
标题:Novel Kinase Inhibitors
摘要:具有该公式的化合物对抑制蛋白酪氨酸激酶具有用处.本发明还揭示了制备这些化合物的方法,含有这些化合物的组合物以及使用这些化合物进行治疗的方法.

专利信息

专利号:US-11542234-B2
优先权日:2018-03-16
标题 :2-alkoxy-6-[18F]fluoronicotinoyl substituted lys-c(O)-glu derivatives as efficient probes for imaging of PSMA expressing tissues
发明人：NEUMAIER BERND; ZLATOPOLSKIY BORIS; KRAPF PHILIPP; RICHARZ RAPHAEL; DRZEZGA ALEXANDER
权利人:UNIV KOELN
摘要:6-[18F]Fluoro-2-alkoxynicotinoyl substituted Lys-C(O)-Glu derivatives were identified as efficient imaging probes for PSMA expressing tissues in comparison to other known PSMA specific ligands like [18F]DCFPyL, [68Ga]HBED-CC-PSMA, [18F]PSMA-1007 and [Al18F]HBED-CC-PSMA. Unexpectedly, the 6-[18F]fluoro-2-alkoxy and 6-[18F]fluoro-4-alkoxy substituted analogs showed significant differences in accumulation in PSMA expressing prostate tumor cells. Whereas the 2-alkoxy derivative showed cellular uptake values higher than [18F]DCFPyL, the cellular uptake of the corresponding 4-alkoxy substituted derivative was significantly lower. Furthermore, in vivo PET studies with 2-alkoxy-substituted probes demonstrated excellent visualization of PSMA positive ganglia with extremely high target to background ratio. In contrast, the 4-alkoxy substituted derivatives showed less favorable biodistribution with significantly lower uptake in PSMA positive tissues. Especially, the 18F-labeled 2-methoxy derivate ((2S)-2-({[(1S)-1-carboxy-5-[(6-[18F]fluoro-2-methoxypyridin-3-yl)formamido]pentyl]carbamoyl}-amino)pentanedioic acid) demonstrated exceptional clinical efficiency in detecting small PCa lesions, including those which could not be visualized with [68Ga]HBED-CC-PSMA representing currently the gold standard for the diagnosis of recurrent PCa. Furthermore, this probe is easily accessible on a preparative scale in commercially available automated synthesis modules like GE FASTlab and TRACERlab FX N Pro. Consequently, the novel probe is a valuable tool for the visualization of ganglia and reendothelialization as well as for the diagnosis of glioma, neuropathic pain and atherosclerotic plaques.

专利号:WO-2022262686-A1
优先权日:2021-06-13
标题 :Kras g12d inhibitors
发明人：HAN YING; LI DAPENG; WANG TONG
权利人:JINGRUI BIOPHARMA CO LTD
摘要:Disclosed are novel compounds which are KRAS G12D inhibitors, their synthesis and their use for treating diseases or conditions, such as cancer, and in particular for inhibiting the activity of KRAS G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

专利号:WO-2012131037-A1
优先权日:2011-03-31
标 题 :Radiolabelled flumazenil derivatives
发明人：SOLBAKKEN MAGNE; GAETA ALESSANDRA; O'SHEA DENNIS; JACKSON ALEXANDER; TRIGG WILLIAM JOHN
权利人:GE HEALTHCARE LTD; SOLBAKKEN MAGNE; GAETA ALESSANDRA; O'SHEA DENNIS; JACKSON ALEXANDER; TRIGG WILLIAM JOHN
摘要:A novel 18F- labelled compound suitable for use as a PET tracer for imaging GABA receptors is provided as well as a precursor compound for use in its synthesis and methods for its preparation. Also disclosed herein is an in vivo imaging method comprising administration of said 18F- labelled compound, which finds use in the diagnosis of conditions in which expression of the GABAA receptor is abnormal, or in the monitoring of such conditions.

专利号:US-7361671-B2
优先权日:2001-11-15
标 题 :Substituted heteroarylalkanoic acids
发明人：VAN ZANDT MICHAEL C; GERACI LEO
权利人:INST PHARMACEUTICAL DISCOVERY
摘要:Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.

专利号:CN-208436829-U
优先权日:2018-05-18
标题:A kind of dichloronicotinic acid synthesis device