CAS: 2243-61-0; Naphthalene-1,4-Diamine

相似化合物

776-34-1 2243-62-1 2243-67-6

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📜1-氨基-4-硝基萘置于5%-Palladium/activated Carbon,氢气体系中,用 四氢呋喃 用作溶剂,化学反应 24.0H,以100%的收率获得1,4-二胺萘
参考文献:解构非共价kelch样ech相关蛋白1(keap1)抑制剂成碎片,以重建新的有效化合物.
标题:解构非共价kelch样ech相关蛋白1(keap1)抑制剂成碎片,以重建新的有效化合物.
摘要:靶向核因子类红细胞2相关因子2(nrf2)和与kelch样ech相关蛋白1(keap1)之间的蛋白相互作用是控制涉及氧化应激疾病的潜在治疗策略.在这里,在基于片段的解构重建(fbdr)研究中,将六类已知的小分子keap1-Nrf2 Ppi抑制剂分解为77个片段,并在四个正交试验中进行了测试.这给出了17个片段命中,其中x射线晶体学显示其中6个在keap1 Kelch结合袋中结合.相对于亲本片段,两个命中片段以220-380倍的亲和力(k I = 16μm)被合并到化合物8中.系统优化产生了一些与k I有关的新颖类似物值0.04-0.5μm,通过x射线晶体学测定的结合模式,以及增强的微粒体稳定性.这证明了fbdr如何可用于发现新的片段片段,阐明重要的配体-蛋白质相互作用以及鉴定keap1-Nrf2 Ppi的新有效抑制剂.
Doi:10.1021/acs.Jmedchem.0C02094

专利信息

专利号:US-9957355-B2
优先权日:2013-06-12
标 题 :Device and method for synthesis of a polymer under separation of a gaseous substance
发明人：ZHU NING; STAMMER ACHIM; CLAUSS JOACHIM; KORY GAD
权利人:BASF SE
摘要:The invention relates to a device for synthesis of a polymer under separation of a gaseous substance. Said device comprises a reaction chamber ( 1 ), which has a top section ( 11 ), a middle section ( 12 ) and a bottom section ( 13 ), an inlet opening ( 2 ) which is arranged in the middle section ( 12 ), a first outlet opening ( 3 ) which is arranged in the bottom section ( 13 ), a second outlet opening ( 4 ) which is arranged in the top section ( 11 ), a first return opening ( 51 ), which is arranged in the bottom section ( 13 ), a second outlet opening ( 52 ), which is arranged under the top section ( 11 ), a distribution device ( 6 ), which is arranged between the top section ( 11 ) and the middle section ( 12 ), and a removal device ( 7 ) which is arranged to be movable along the top section ( 11 ). The invention further relates to a method for synthesis of a polymer which can be carried out in said device.

专利号:US-9631051-B2
优先权日:2013-06-12
标 题:Device for the synthesis of a polymer with extraction of a gaseous substance comprising a reaction chamber having at least one circular-cylindrical section
发明人：ZHU NING; STAMMER ACHIM; CLAUSS JOACHIM; KORY GAD
权利人:BASF SE
摘要:An apparatus for synthesis of a polymer with separation of a gaseous substance comprises a reaction space having an essentially circular cylindrical upper section which is bounded by two circular faces and one shell face and has a longitudinal cylinder axis, and a lower section, an inlet orifice disposed in a circular face or the shell face of the upper section, a first outlet orifice disposed in a wall of the lower section, a second outlet orifice disposed in the shell face of the upper section opposite the first outlet orifice, and a removal device which is disposed so as to be rotatable about the longitudinal cylinder axis and is in contact with both circular faces and the shell face. This apparatus can especially be used for performance of a process including the feeding of an oligomer melt into a reaction space through an inlet orifice, the polymerization of the oligomer melt to give a polymer melt, the removal of the polymer melt from the reaction space through a first outlet orifice of the reaction space, and the removal of a gaseous substance from the reaction space through a second outlet orifice of the reaction space, wherein deposits on at least one inner wall of the reaction space are removed by a removal device and transported into the oligomer melt.

专利号:US-10808079-B2
优先权日:2015-03-27
标 题:Synthesis of copolyimides containing fluorine and silicon surface modifying agents
发明人：CONNELL JOHN W; WOHL JR CHRISTOPHER J; DOSS JEREME R; CROW ALLISON M; KIM WILLIAM T; LIN YI
权利人:NASA
摘要:Various embodiments provide random copolyimides that may possess the mechanical, thermal, chemical and optical properties associated with polyimides yet achieve a low energy surface. In various embodiments, the copolyimides may be prepared using a minor amounts of a diamino terminated fluorinated alkyl ether oligomer and a diamino terminated siloxane oligomer. The various embodiments include processes for making the copolyimides containing fluorine and silicon surface modifying agents and anisotropic coatings and articles of manufacture from them. Thus the coatings and articles of manufacture made with the copolyimides of the various embodiments may be characterized as having an anisotropic fluorine and silicon composition and low surface energy.

专利号:US-8329854-B2
优先权日:2010-09-27
标题 :Synthesis of tri-component resins
发明人：BIRAU MARIA; ALLEN C GEOFFREY
权利人:BIRAU MARIA; ALLEN C GEOFFREY; XEROX CORP
摘要:A resinous compound of the formulas or a salt thereof, wherein G1 is —X1C(O)OR1, —X2OC(O)R2, or —X2OH; G2 is R4, R12, —C(O)R2, —C(O)X1C(O)OR1, or —C(O)X2OC(O)R2; R1 is an alkyl having from 10 to 80 carbon atoms; R2 is an alkyl having from 2 to 40 carbon atoms; each R3 and R4 is independently hydrogen, alkyl, arylalkyl or alkylaryl; each R5 and each R6 is independently hydrogen or alkyl; X1 and X2 are both a straight or branched alkylene group; t1 is 1 to 20; t2 and t3 is independently 0 to 20; u1 is 1 to 30; u2 and u3 is independently 0 to 30; each R7 and each R8 is independently hydrogen, alkyl, or alkoxyl; each R9 and each R10 is independently hydrogen, alkyl, or alkoxyl; Ar is a substituted or unsubstituted aromatic moiety; p is 1 to 5; q is 1 to 12; A⊖ is selected from the group consisting of Cl−, Br−, I−, HSO4−, HSO3−, CH3SO3−, NO3−, HCOO−, CH3COO−, H2PO4−, SCN−, BF4−, ClO4−, SSO3−, PF6−, and SbCl6−; and J is alkyl, arylalkyl, or alkylaryl.

专利号:US-2013102730-A1
优先权日:2010-04-02
标 题:Polyamine-containing polymers and methods of synthesis and use
发明人：JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN
权利人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN; ALBERTA INNOVATES TECHNOLOGY FUTURES
摘要:The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).

专利号:US-2024279231-A1
优先权日:2021-05-20
标题:Map4k4 inhibitors and methods of synthesis and use thereof
发明人：AWASTHI VIBHUDUTTA; EEDA VENKATESWARARAO
权利人:UNIV OKLAHOMA
摘要:The compound DMX-5804, IUPAC name 5-(4-(2-methoxyethoxy)phenyl)-7-phenyl-3,4a,7,7a-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, is a potent and selective inhibitor of mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4). The present disclosure describes a scalable and practical synthesis process for making DMX-5804. The process (1) doesn't rely on transition metals, (2) has reduced duration of reactions, (3) is streamlined with significantly improved yields using low cost raw materials, (4) includes no microwave-assisted reactions, (5) does not require column purification, and (6) generally results in crystalized products having over a 95% purity in each step. The present disclosure also describes DMX-5804 analogs and derivatives for use in inhibiting MAP4K4, and scalable and practical processes for making such DMX-5804 analogs.