CAS: 20260-53-1; Nicotinoyl Chloride Hydrochloride

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39620-02-5 58757-38-3 49609-84-9

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CAS号636-79-3 3-吡啶羧酸 | CAS号59-67-6 烟酸 | CAS号110576-10-8 4-[(pyridine-3-... | CAS号5424-19-1 3-苯酰基嘧啶 | CAS号500-22-1 吡啶-3-甲醛 | CAS号37669-64-0 5-溴-3-吡啶甲醇 | CAS号142669-79-2 N-[4-(pyridine-... | CAS号142566-02-7 N-butyl-N-methy... | CAS号14621-03-5 3-Pyridinecarbo... | CAS号143570-62-1 N-benzyl-N-tert... | CAS号94-44-0 烟酸苄酯 | CAS号189169-96-8 N-[(2-nitrophen...

烟酸置于氯化亚砜体系中,化学反应 4.0H,以100%的收率获得氯化烟碱盐酸盐
参考文献:Homochiral Crystallization Of Helical Coordination Chains Bridged By Achiral Ligands: Can It Be Controlled By The Ligand Structure
标题:Homochiral Crystallization Of Helical Coordination Chains Bridged By Achiral Ligands: Can It Be Controlled By The Ligand Structure
摘要:描述了通过非手性的多吡啶配体连接的螺旋手性聚合物链的同手性/异手性结晶过程,这一过程取决于连接配体的结构,而与溶剂无关,暗示了一种设计螺旋链非手性晶体的潜在策略,即使用手性连接配体.
Doi:10.1039/b416412A

专利信息

专利号:US-6423847-B1
优先权日:1999-04-07
标题:Synthesis and clinical uses of D,α-tocopherol nicotinate compounds
发明人：PEARSON DON C; RICHARDSON KENNETH T
权利人:CHRONORX LLC
摘要:A process of synthesis of D,alpha-tocopherol nicotinate compounds is presented. Therapeutic uses for this compound are described. The active agents are demonstrated to be complementary in their physiological functions especially as these relate to cellular and endothelial biochemistry and physiology and, ultimately to vascular health. The active components of the invention are selected for inclusion in a unique combination that clinically reduces risks of vasculopathy, DNA strand breakage and neuronal excitotoxicity in various diseases. In addition to the systemic vascular benefits acquired, improvement of the vascular health of the eye reduces the risk of glaucomatous optic nerve atrophy with its accompanying visual field loss and potential blindness and reduces conditions of risk for macular degeneration.

专利号:US-6693122-B2
优先权日:1999-05-12
标题:Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
发明人：GARVEY DAVID S; SAENZ DE TEJADA INIGO
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated potassium channel activators, and novel compositions comprising at least one nitrosated and/or nitrosylated potassium channel activator, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one vasoactive agent. The present invention also provides novel compositions comprising at least one potassium channel activator, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one vasoactive agent. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing cardiovascular disorders, cerebrovascular disorders, hypertension, asthma, baldness, urinary incontinence, epilepsy, sleep disorders, gastrointestinal disorders, migraines, irritable bowel syndrome and sensitive skin.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-4021436-A
优先权日:1974-03-15
标题 :Derivatives of nicotinic acid with amines variously substituted
发明人：CAVAZZA CLAUDIO
权利人:CAVAZZA CLAUDIO
摘要:A novel thionicotinate of nicotinamide is disclosed having the formula: ##STR1## The compound has the useful pharmacological activity of lowering cholesterol, free fatty acid and triglyceride plasma levels. In cases of liver injury, administration of the compound has modified toward normal the injury-induced malfunction of the liver. A synthesis of the compound from nicotinoyl chloride hydrochloride is described as well as modes for the administration of the compound.

专利号:US-4021433-A
优先权日:1973-03-08
标 题:Derivative of nicotinic acid with amides
发明人：CAVAZZA CLAUDIO
权利人:SIGMA TAU IND FARMACEUTI
摘要:A novel cysteine thiolactone of nicotinamide is disclosed having the formula: ##STR1## The compounds, homo-cysteine thiolactone of nicotinamide, and its pharmacologically acceptable salts have the useful pharmacological activity of lowering cholesterol, free fatty acid and triglyceride plasma level in the case of altered lipid metabolism and improving BSP clearance ratio in cases of liver injury. n A synthesis of the compound from nicotinoyl chloride, hydrochloride or nicotinic acid esters is described as well as modes for the administration of the compound.