CAS: 18171-59-0; (Dichloromethyl)Dimethylchlorosilane

上下游产品

chloro-trimethyl-silane Chloro(chloromethyl)dimethylsilane (dichloromethyl)trimethylsilane chloro-chloromethyl-dimethylsilane 1,3-bis-dichloromethyl-1,1,3,3-tetramethyl-disiloxane 3H8Cl2O4SSiC3H8Cl2O4SSi

📜三甲基氯硅烷 反应生成(二氯甲基)二甲基氯硅烷
参考文献:The Preparation And Properties Of Some Chloromethylchlorosilanes
标题:The Preparation And Properties Of Some Chloromethylchlorosilanes
摘要:
Doi:10.1021/ja01226A057

专利信息

专利号:US-6008400-A
优先权日:1995-06-09
标题 :Orthoester reagents for use as protecting groups in oligonucleotide synthesis
发明人：SCARINGE STEPHEN; CARUTHERS MARVIN H
摘要:Phosphoramidite oligonucleotide synthesis is facilitated by the use of fluoride-labile 5' silyl protecting groups. RNA synthesis is improved by the use of 2 orthoester protecting groups. Reactions are conducted on a solid phase support and acidic deprotection conditions are avoided, as is the necessity of oxidizing the phosphite linkage between each coupling reaction.

专利号:US-10450331-B2
优先权日:2015-07-23
标 题:Functionalized cyanosilane and synthesis method and use thereof
发明人：ZHOU JIAN; ZENG XINGPING
权利人:UNIV EAST CHINA NORMAL
摘要:The present teachings relate to a functionalized silyl cyanide and synthetic methods thereof. As an example, the method may include adding a raw material silane and a cyanide source MCN in an organic solvent to produce the functionalized silyl cyanide in the absence of catalyst or in the presence of a metal salt catalyst. The functionalized silyl cyanide may be used in the reactions that classic TMSCN participates in, to synthesize important intermediates (e.g., cyanohydrin, amino alcohols and α-amino nitrile compounds), with improved reactivity and selectivity. The cyanosilyl ether resulted from the nucleophilic addition of functionalized silyl cyanide to aldehyde or ketone may undergo intramolecular reaction under appropriate conditions to transfer the functional groups on silicon onto the other parts of the product linked to silicon. Such a functional group transfer process may increase the synthesis efficiency and atom economy, as well as afford products unobtainable using traditional TMSCN.