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CAS号2487-90-3 三甲氧基硅烷 | CAS号7766-50-9 11-溴-1-十一烯 | CAS号877593-17-4 11-巯基十一烷基三甲氧基硅烷专利信息
专利号:US-9303055-B2
优先权日:2001-03-14
标题 :Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
发明人:GAO XIAOLIAN; ZHANG HUA; YU PEILLIN; LEPROUST ERIC; PELLOIS JEAN PHILIPPE; XIANG QIN; ZHOU XIAOCHUAN
权利人:UNIV MICHIGAN; UNIV HOUSTON
摘要:A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.
专利号:US-2020148803-A1
优先权日:2018-11-09
标 题:Polymerizable multifunctional antimicrobial quaternary ammonium monomers, methods of synthesis, and uses thereof
发明人:FRUKHTBEYN STANISLAV; OKEKE UGOCHUKWU; BIENEK DIANE; SKRTIC DRAGO; ANTONUCCI JOSEPH; GIUSEPPETTI ANTHONY
权利人:ADA FOUND
摘要:in which structure a) includes functional groups R1, R2, R3, R4 and anion X and structure b) includes functional groups R1, R3, R4, R5 and anion R2, and in which structure a) is one of an ammonium monomer adhesive (AMadh) configuration and an ammonium monomer silane (AMsil) configuration, and structure b) is an ammonium monomer miscible (AMmis) configuration.
专利号:US-2003120035-A1
优先权日:2001-03-14
标 题:Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
专利号:US-7211654-B2
优先权日:2001-03-14
标 题:Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
专利号:US-2007287832-A1
优先权日:2001-03-14
标 题:Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
专利号:US-7807807-B2
优先权日:2001-03-14
标题 :Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports