CAS: 1721-69-3; ((1R,3As,5Ar,5Br,7Ar,9S,11Ar,11Br,13Ar,13Br)-9-Acetoxy-5A,5B,8,8,11A-Pentamethyl-1-(Prop-1-En-2-yl)Icosahydro-3Ah-Cyclopenta[a]Chrysen-3A-yl)Methyl Acetate
该化合物是属于三叶类的化学化合物,具体来自乳腺类结构,这种化合物具有四环结构特征,具有许多天然长地的典型的四环结构,其特点是有引信环状系统;3和28个位置上存在氢氧基体组,表明它有酒精功能,有助于其再活性和潜在的生物活动;二乙酸盐的指定表明这些氢氧基组是乙酰,加强了该化合物的亲性性和稳定性;这种三叶类动物往往存在于各种植物物种中,并因其不同的药性特性而闻名,包括抗炎,抗氧化剂和潜在的抗癌活动;3个位置上的特定立体化学化学化学组系对于其生物相互作用至关重要;
- 英文名称((1R,3As,5Ar,5Br,7Ar,9S,11Ar,11Br,13Ar,13Br)-9-Acetoxy-5A,5B,8,8,11A-Pentamethyl-1-(Prop-1-En-2-yl)Icosahydro-3Ah-Cyclopenta[a]Chrysen-3A-yl)Methyl Acetate
- 中文名称桦木脑二乙酸
- IUPAC名称((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-acetoxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysen-3a-yl)methyl acetate
- 其它别名[(1R,3As,5Ar,5Br,7Ar,9S,11Ar,11Br,13Ar,13Br)-9-Acetyloxy-5A,5B,8,8,11A-Pentamethyl-1-Prop-1-En-2-Yl-1,2,3,4,5,6,7,7A,9,10,11,11B,12,13,13A,13B-Hexadecahydrocyclopenta[a]Chrysen-3A-Yl]Methylacetate
- CAS编号1721-69-3
- MFCD编号:MFCD00017378
- EINECS号:217-015-5
- FDA UNII编号:U2YW502S1Q
- 分子式:C34H54O4分子量:526.8
- 产品CID: 882160
- 产品分类分析化学 → 标准品 → 分析标准品
物理性质
- 熔点221-223 °C
- 沸点548.1±23.0 °C at 760 mmHg
- 闪点258.0±21.0 °C
- 密度1.1±0.1 g/cm3
- PH:D20 +22° (c = 1.2 in CHCl3)
- PSA:52.6
- LogP:10.8
- 折射率1.526
- 蒸汽压0.0±1.5 mmHg at 25°C
- 溶解性Chloroform: 10 mg/mL,DMF: Slightly Soluble,DMSO: Slightly Soluble
- 外观形态白色至类白色固体
- 储存条件2-8°C
- 产品应用该化合物是贝图林的三叶杆和衍生物,具有抗病毒和肝脏保护活动,抑制SEMLIKI FOREST病毒(SFV)在受病毒感染的HH7细胞(IC50=9.1微克/M)中的复制.BETULLIN DIACETATATE(20毫克/千克)增加了BILE分泌率,这是由四氯化碳,乙醇或四环乙烷引发的肝炎的老鼠模型中的肝脏功能标志.
上下游产品
betulin acetic anhydride 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl bromide 28-acetoxybetulin20-oxo-29-norlupane-3β,28-diyl diacetate ()-3β,28-diacetoxydihydrobetulin allobetulin betulin合成工艺路线路线简述
📜白桦脂酸置于吡啶,Lithium Aluminium Tetrahydride体系中,化学反应生成桦木脑二乙酸
参考文献:有机光化学-第二部分,天然存在的三萜内酯,3β-羟基lupan-28,13β-内酰胺的光化学合成
标题:有机光化学-第二部分,天然存在的三萜内酯,3β-羟基lupan-28,13β-内酰胺的光化学合成
摘要:标题内酯的光化学合成是通过在单独的乙酸铅(iv)或乙酸铅(iv)+碳酸钙+碘或氧化汞+碘的存在下进行辐照而实现的.对该内酯和其他相关内酯的整脊测量(cd)提供了令人信服的证据来支持内酯环结构.
Doi:10.1016/s0040-4039(00)99143-3
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2909110000-乙醚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8969395-B2
优先权日:2009-05-20
标题 :Triterpenoid derivatives useful as antiproliferative agents
发明人：RIBEIRO SALVADOR JORGE ANTONIO; MENDES DOS SANTOS RITA CATARINA; CASCANTE SERRATOSA MARTA
权利人:RIBEIRO SALVADOR JORGE ANTONIO; MENDES DOS SANTOS RITA CATARINA; CASCANTE SERRATOSA MARTA; UNIV DE COIMBRA
摘要:Formula (I) and (II). The present invention relates to the use of a new lupane derivative of general formula (I) or (II), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, for preventing and/or inhibiting tumor growth and for treating cancer and other proliferative diseases, more particularly for treating leukemia, liver, cervical, colon and prostate cancer. The present invention also relates to the synthesis of these compounds and to pharmaceutical compositions which contain them.
专利号:RU-2190622-C1
优先权日:2001-12-26
标 题 :Method of synthesis of betulinic acid
专利号:RU-2150473-C1
优先权日:1999-08-09
标 题:Method of synthesis of betulinol diacetate
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Mikhailenko MA, Shakhtshneider TP, Eltsov IV, Kozlov AS, Kuznetsova SA, Karacharov АА, Boldyrev VV. Supramolecular architecture of betulin diacetate complexes with arabinogalactan from Larix sibirica. Carbohydr Polym. 2016 Mar 15;138:1-7. doi: 10.1016/j.carbpol.2015.11.047. Epub 2015 Nov 21. doi: 10.1080/14786419.2015.1060591. Epub 2015 Jul 13. doi: 10.1016/j.bmc.2010.01.003. Epub 2010 Jan 7. Russian. Russian.
合成参考文献
参考文献:10.1021/np060046r
摘要:Madureira AM, Gyémánt N, Ascenso JR, Abreu PM, Molnár J, Ferreira MU. Euphoportlandols A and B, Tetracylic Diterpene Polyesters from Euphorbia portlandica and Their Anti-MDR Effects in Cancer Cells. J. Nat. Prod. 2006 May 10;69(6):950–3. doi: 10.1021/np060046r.
📝 需求与反馈
尽可能描述清楚需求与问题信息
