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专利信息
专利号:US-2005019747-A1
优先权日:2002-08-07
标 题 :Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
发明人:ANDERSON DANIEL G; LEVENBERG SHULAMIT; LANGER ROBERT S
摘要:A method of screening cell-polymer interactions. The method includes depositing monomers as a plurality of discrete elements on a substrate, causing the deposited monomers to polymerize, thereby creating an array of discrete polymer elements on the substrate, incubating the substrate in a cell-containing culture medium, and characterizing a predetermined cell behavior on each polymer element.
专利号:CA-2539670-A1
优先权日:2003-09-15
标 题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
专利号:WO-2005028619-A2
优先权日:2003-09-15
标题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
专利号:EP-1675943-A4
优先权日:2003-09-15
标 题 :SYNTHESIS OF BIOMATERIALS ARRANGED IN AN ARRAY IN THE NANOLITE ASSEMBLY AND SCREENING THEREOF
专利号:EP-1675943-A2
优先权日:2003-09-15
标题 :Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
专利号:US-2011183867-A1
优先权日:2007-08-09
标题 :Polymer arrays for biofilm adhesion testing
发明人:DAVIES MARTYN CHRISTOPHER; ALEXANDER MORGAN; WILLIAMS PAUL; LANGER ROBERT; ANDERSON DANIEL; URQUHART ANDREW
权利人:UNIV NOTTINGHAM; MASSACHUSETTS INST TECHNOLOGY
摘要:This invention relates to a method of screening arrays of polymers having pre-determined surface energies. The polymer arrays of the present invention can be used to screen for microorganism adherence. More specifically the arrays can be used to screen for adherence of particular bacteria or fungi to particular polymers in the array. Furthermore, this invention relates to a method combining in-situ polymer synthesis with physico-chemical characterisation of the resulting polymer array and subsequent biological assays of bacterial or fungal adherence. This allows for high throughput screening and characterisation of candidate polymers which are not susceptible to bacterial or fungal adherence or which can be used to support bacterial or fungal adherence where such is required. The arrays can also be used to screen for inhibition or promotion of biofilm formation.