专利号:US-5922335-A 优先权日:1995-05-15 标 题:Uses for ascorbyl-phosphoryl-cholesterol in topical compositions 发明人:PTCHELINTSEV DMITRI 权利人:AVON PROD INC 摘要:Novel uses of 3'-(L-ascorbyl-2-o-phosphoryl)-cholesterol, 3'-(L-ascorbyl-3-o-phosphoryl)-cholesterol, structural or functional isomers thereof and salts thereof (referred to collectively as 'APC compounds') are disclosed. Such novel uses include a method of reducing epidermal synthesis of abnormal elastin, especially epidermal synthesis of abnormal elastin that results from exposure to UV radiation. Also disclosed is a novel method of stimulating keratinocyte formation of triglycerides. In addition, a novel method of achieving antioxidant activity, both in the skin and also in topical compositions, is disclosed.
专利号:EP-1776333-B1 优先权日:2004-07-21 标 题:Ammonium salts and ammonium salt/mineral salt clathrate compounds for use as vehicle and effective form for pharmaco-medical applications and for use as phase transfer agents for chemical applications 发明人:REUTER UWE; OETTMEIER RALF; KASCH HELMUT 权利人:KASCH HELMUT 摘要:This invention relates to ammonium salts and stable storable ammonium salts and ammonium salt/mineral salt clathrate compounds (inclusion compounds, clusters) having acid dibasic anionic acid residues such as bicarbonate, to methods for producing them and to pharmaco-medical and chemical synthetic applications for said compounds. According to the invention, compounds for pharmaco-medical and chemical synthetic applications are produced which comprise the ammonium salt and ammonium salt/mineral salt clathrate compounds (inclusion compounds, clusters) having acid dibasic anionic acid residues of general formula I with R1, R2, R3 and R4=alkyl and substituted alkyl straight-chain or branched, optionally having an alcohol, ether, silyether, ester, amino or amide function, H or aryl-alkyl, with aryl being an aromatic or heteroaromatic ring having optionally additional substituents, such as alkyl having 1 to 4 C atoms, OH, NR*2 with R*2=O, alkyl with alkyl of between 1 and 4 C atoms or H, COOH, COOR, CN, NO2 and the cationic positive N+ is optionally part of an active agent, Y is a dibasic acid residue of an organic dicarboxylic acid or CO3-, corresponding to HY-=HCO3-, and x=0.5 to 30 represents the number of the mineral salt molecules for clathrate compound formation or 0. In pharmaco-medical applications applies the generalizable effectiveness principle according to which to ammonium salt/mineral salt cluster is used as vehicle and active agent for novel forms of application of nitrogen-containing active agent bases. In chemistry, these agents are used in the synthesis of active agents and valuable products, e.g. of cyclic carbonates.
专利号:CN-108569966-A 优先权日:2017-03-08 标题:The synthesis of dimethyl butyn
专利号:CN-103224502-A 优先权日:2012-01-30 标 题:Adapters and Supports for Solid-Phase Synthesis of Nucleic Acids
专利号:US-7993390-B2 优先权日:2002-02-08 标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation 发明人:MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN 权利人:BOSTON SCIENT SCIMED INC 摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.
专利号:WO-2005059141-A1 优先权日:2003-12-17 标题 :Method of constructing yellow flower by regulating flavonoid synthesis system
摘要:American Journal of Physiology., 68(110), 1924 摘要:M. E. Krahl, A. K. Keltch, and G. H. A. Clowes. J. Pharmacol. Exptl. Therap. 68, 330 (1940). 摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664