CAS: 1486-70-0; 2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-3-Methoxy-4H-Chromen-4-One

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CAS号1486-57-3 2-(3,4-bis(benz... | CAS号55317-02-7 2-甲氧基-1-(2,4,6-... | CAS号108-73-6 间苯三酚 | CAS号5447-02-9 3,4-二苄氧基苯甲醛 | CAS号1570-05-4 3,4-二(苄氧基)苯甲酸 | CAS号1486-54-0 3,4-二(苄氧基)苯甲酰氯 | CAS号183067-65-4 2-(3,4-bis(benz... | CAS号153-18-4 芦丁 | CAS号1486-69-7 四乙酸 3-O-甲基槲皮素酯 | CAS号33429-83-3 槲皮素3,4'-二甲醚; 5,... | CAS号2068-02-2 3,7-二-O-甲基槲皮素 | CAS号572-32-7 阿亚黄素，缎木素

📜芦丁置于盐酸,Palladium 10% On Activated Carbon,氢气,Potassium Carbonate体系中,用 1,4-二氧六环,乙醇,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 11.5H,反应生成3-邻甲基槲皮素
参考文献:Discovery Of Metal Ions Chelator Quercetin Derivatives With Potent Anti-Hcv Activities
标题:Discovery Of Metal Ions Chelator Quercetin Derivatives With Potent Anti-Hcv Activities
摘要:α,γ-二酮酸(dka)1A的类似物或同系物通过螯合活性部位的两个镁离子,显示出对丙型肝炎病毒(hcv)ns5B聚合酶的强效抑制作用.黄酮类化合物槲皮素(2)的抗hcv活性部分可归因于其作为dka的结构模拟物.为了阐明抑制作用所需的结构特征并提高抗hcv效力,设计,合成了两种新型槲皮素类似物,即7-O-芳甲基槲皮素和槲皮素-3-O-苯甲酸酯,并在基于细胞的实验中评估了它们的抗hcv特性.在38个新合成的化合物中,7-O-取代衍生物3I和3-O-取代衍生物4F在相应系列中最具活性(ec50分别为3.8 μm和9.0 μm).对接研究表明,槲皮素类似物能够与hcv Ns5B活性部位的两个镁离子建立关键配位,并与其残基相互作用.
Doi:10.3390/molecules20046978

专利信息

专利号:US-2024026314-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
发明人：ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.

专利号:US-10967019-B2
优先权日:2015-11-30
标 题 :Method for protecting mitochondria in retina cell
发明人：CHENG HAN-CHUNG; TU CHI-TANG; YANG SHUN-CHIEH; SHEN MAN-CHING
权利人:TAIWAN MITOCHONDRION APPLIED TECH CO LTD
摘要:A use of an emblica extract in preparing a pharmaceutical composition for protecting mitochondria in retina is provided. When the pharmaceutical composition, which comprises the emblica extract, is provided to retinal cells, a use of the pharmaceutical composition comprises improvement of the ability of performing the oxidative phosphorylation for the synthesis of the adenosine triphosphate (ATP) by the mitochondria in the retinal cells under or exposed to ultraviolet light, and improvement of the coupling efficiency of the synthesis of the adenosine triphosphate by the mitochondria.

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

专利号:EP-4251758-A1
优先权日:2020-11-25
标 题:Polypeptides for use in the synthesis of bioactive phenolic compounds

专利号:CN-110408649-B
优先权日:2019-07-25
标题:Application of NOR gene and its encoded protein in regulating the synthesis of flavonoids in tomato fruit

专利号:WO-2022109736-A1
优先权日:2020-11-25
标题:Polypeptides for use in the synthesis of bioactive phenolic compounds