CAS: 1410880-22-6; 3-(4-(Dimethylamino)But-2-Enamido)-N-(3-Methyl-4-((4-(Pyridin-3-yl)Pyrimidin-2-yl)Amino)Phenyl)Benzamide
- 英文名称3-(4-(Dimethylamino)But-2-Enamido)-N-(3-Methyl-4-((4-(Pyridin-3-yl)Pyrimidin-2-yl)Amino)Phenyl)Benzamide
- 中文名称化合物JNK-IN-8
- IUPAC名称3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
- CAS编号1410880-22-6
- MFCD编号:MFCD22124890
- 分子式:C29H29N7O2分子量:507.6
- 产品CID: 629510
- 产品分类生物化工 → 抑制剂 → 丝裂原活化蛋白激酶(MAPK)
物理性质
合成工艺路线路线简述
海关参考信息
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专利信息
专利号:US-2025049791-A1
优先权日:2023-08-03
标题:Synthesis of MEK7 Inhibitors and methods of Use Thereof
发明人：SCHEIDT KARL A; KIM DALTON ROBERT; ORR MEGHAN JO
权利人:UNIV NORTHWESTERN
摘要:Disclosed herein are 4-phenoxypyrimidine compounds and derivatives thereof for use as inhibitors of mitogen-activated protein kinase 7 (MEK7). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with MEK7 activity, including cell proliferative diseases and disorders associated with MEK7 activity, such as cancer.
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主要参考文献
1: Xie X, Kaoud TS, Edupuganti R, Zhang T, Kogawa T, Zhao Y, Chauhan GB, Giannoukos DN, Qi Y, Tripathy D, Wang J, Gray NS, Dalby KN, Bartholomeusz C, Ueno NT. c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun. Oncogene. 2016 Dec 12. doi: 10.1038/onc.2016.417. [Epub ahead of print] doi: 10.1016/j.brainres.2016.10.013. doi: 10.1016/j.chembiol.2011.11.010.
4: Pathria G, Garg B, Garg K, Wagner C, Wagner SN. Dual c-Jun N-terminal kinase-cyclin D1 and extracellular signal-related kinase-c-Jun disjunction in human melanoma. Br J Dermatol. 2016 Dec;175(6):1221-1231. doi: 10.1111/bjd.14713. doi: 10.1016/j.bbrc.2013.09.130.
合成参考文献
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
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