CAS: 1226056-71-8; N-Benzyl-2-(Pyrimidin-4-Ylamino)Thiazole-4-Carboxamide

上下游产品

CAS号163133-86-6 4(1H)-Pyrimidin...

📜在 三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 6.0H,以52.1%的收率获得n-苄基-2-(嘧啶-4-基氨基)噻唑-4-羧酰胺
参考文献:一种离子液体及利用其合成thiazovivin的方 法
标题:一种离子液体及利用其合成thiazovivin的方 法
摘要:本发明提供一种用于合成thiazovivin的离子液体,属于有机合成技术领域.所述离子液体具有如下通式1所示的结构:本发明还提供一种基于上述离子液体的thiazovivin合成方法,包括(1)将所述离子液体与苄胺连接得到化合物4;(2)将上述化合物4与2‑溴噻唑‑4‑羧酸进行酰化反应得到化合物5;(3)上述化合物5与4‑氨基嘧啶进行胺化反应得到化合物6;(4)将上述化合物6中的离子液体去掉即可得到所述thiazovivin.

专利信息

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.