CAS: 115962-35-1; (R)-2-(Tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid

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📜(R)-(+)-1,2,3,4-四氢异喹啉-3-羧酸 以54%的收率获得
参考文献:Kazmierski,Wieslaw;Hruby,Victor J.,Tetrahedron,44,(1988) N 3,697-710
标题:Kazmierski,Wieslaw;Hruby,Victor J.,Tetrahedron,44,(1988) N 3,697-710

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.