CAS: 946525-43-5; (4-(Difluoromethyl)Phenyl)Boronic Acid

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  • 15164-44-0 = 946525-43-5
    反应条件:1.1 Reagents: (Diethylamino)Sulfur Trifluoride Solvents: Dichloromethane1.2 Reagents: Chloro(1-Methylethyl)Magnesium Solvents: Toluene,Tetrahydrofuran; Rt -> -70 °C; 30 Min,-70 °C1.3 Reagents: Trimethyl Borate; -70 °C -> -20 °C1.4 Reagents: Hydrochloric Acid Solvents: Water; -20 °C -> Rt
    标题:Glucopyranosyl-Substituted Benzonitrile Derivatives,Pharmaceutical Compositions Containing Such Compounds,Their Use And Process For Their Manufacture
    参考文献:World Intellectual Property Organization]

    15164-44-0 = 946525-43-5
    反应条件:1.1 Reagents: (Diethylamino)Sulfur Trifluoride Solvents: Dichloromethane1.2 Reagents: Chloro(1-Methylethyl)Magnesium Solvents: Toluene,Tetrahydrofuran,Hexane; Rt -> -70 °C; 30 Min,-70 °C1.3 Reagents: Trimethyl Borate,Hydrochloric Acid Solvents: Water; -70 °C -> -20 °C; -20 °C -> Rt
    标题:Process For The Preparation Of Glucopyranosyl-Substituted Benzonitriles For Use As Therapeutic Agents Treating Metabolic Disorders
    参考文献:United States
📜1-Iodo-4-(Difluoromethyl)Benzene,异丙基氯化镁,硼酸三甲酯 反应生成 4-二氟甲基苯硼酸
参考文献:Glucopyranosyl-Substituted Benzonitrile Derivatives,Pharmaceutical Compositions Containing Such Compounds,Their Use And Process For Their Manufacture
标题:Glucopyranosyl-Substituted Benzonitrile Derivatives,Pharmaceutical Compositions Containing Such Compounds,Their Use And Process For Their Manufacture
摘要:根据权利要求1所定义的葡萄糖吡喃取代苯腈衍生物,包括其互变异构体,立体异构体,混合物及其盐.本发明的化合物适用于治疗代谢性疾病.

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参考文献:10.1007/s00044-021-02751-4
摘要:Liu W, Chen H, Zhang X, Zhang X, Xu L, Lei Y, Zhu C, Ma B. Isatin derivatives as a new class of aldose reductase inhibitors with antioxidant activity. Medicinal Chemistry Research. 2021 Jun 18;30(8):1588–602. doi: 10.1007/s00044-021-02751-4.
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