CAS: 931-94-2; 1,1-Dimethoxycyclopentane

该化合物是有机化合物,其结构特征包括五角脊柱,配有两种甲氧(-OCH3)组,一般是室温无色液体,以相对低的粘度和中度挥发性而著称.二甲基二氧丙烷在有机溶剂中可溶解,但由于其具有水分的五角氧链,其溶解性有限.它经常被用作溶剂或试剂,用于各种化学反应和应用,特别是有机合成中.混合氧组的存在有助于其再活动,使其能够参与核分裂性替代反应.此外,甲氧二氧苯丙烷可能具有低毒性和易燃性等特性,这些特性是处理和储存的重要考虑因素.与许多有机化合物一样,应当采取安全防范措施,以尽量减少接触,并确保实验室或工业环境中的安全使用.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号67-56-1 甲醇 | CAS号120-92-3 环戊酮 | CAS号149-73-5 原甲酸三甲酯 | CAS号1825-61-2 甲氧基三甲基硅烷 | CAS号17497-52-8 1-Cyclopentenyl... | CAS号40648-08-6 1-iodo-2-methyl... | CAS号120-92-3 环戊酮 | CAS号67-56-1 甲醇 | CAS号2520-60-7 penten-1-yl cyc... | CAS号158432-46-3 Ethanone, 2,2,2... | CAS号1192-04-7 1-溴环戊-1-烯 | CAS号6789-46-4 6,7,14,15,22,23... | CAS号88441-46-7 methyl 4-cyclop... | CAS号63964-69-2 methyl 2,3-dihy...

合成工艺路线路线简述

  • 120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Methanol; 8 - 24 H,Rt1.2 Reagents: Sodium Methoxide Solvents: Methanol; Rt
    标题:Fmphos: Expanding The Catalytic Capacity Of Small-Bite-Angle Bisphosphine Ligands In Regioselective Alkene Hydrofunctionalizations
    作者:Chen,Xiao-Yang; Zhou,Xukai; Wang,Jianchun; Dong,Guangbin
    参考文献:Acs Catalysis 日期:2020 卷标:10(24) 页码:14349-14358]

    120-92-3 = 931-94-2
    反应条件:1.1 Reagents: Trimethyl Orthoformate Solvents: Methanol; 8 H,0.8 Gpa,40 °C
    标题:High-Pressure-Promoted Uncatalyzed Ketalization Of Ketones And Oxy-Michael/ketalization Of Conjugated Enones
    作者:Kumamoto,Koji; Ichikawa,Yoshiyasu; Kotsuki,Hiyoshizo
    参考文献:Synlett 日期:2005 卷标:(14) 页码:2254-2256]

    120-92-3 = 931-94-2
    反应条件:1.1 Reagents: Trimethyl Orthoformate Catalysts: Hydrochloric Acid Solvents: Methanol; 24 H,40 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; > 1 Min,40 °C
    标题:A Simple And Versatile Method For The Formation Of Acetals/ketals Using Trace Conventional Acids
    作者:Dong,Jian-Lian; Yu,Li-Si-Han; Xie,Jian-Wu
    参考文献:Acs Omega 日期:2018 卷标:3(5) 页码:4974-4985]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: Sulfuric Acid Solvents: Water; 10 Min,Rt
    标题:Production Of Ketone-Based Biopolymers From Catalytic Fast Pyrolysis Of Biomass
    参考文献:United States]

    120-92-3 = 931-94-2
    反应条件:1.1 Reagents: Trimethyl Orthoformate Catalysts: Methanesulfonic Acid,1,1,1-Trifluoro-,Cerium(3+) Salt (3:1) Solvents: Methanol; Rt; 45 Min,Rt1.2 Reagents: Triethylamine; Rt
    标题:A Facile Procedure For Acetalization Of Aldehydes And Ketones Catalyzed By Cerium(Iii) Trifluoromethanesulfonate
    作者:Ono,Fumiaki; Inatomi,Yoshiko; Tada,Yuusuke; Mori,Masaki; Sato,Tsuneo
    参考文献:Chemistry Letters 日期:2009 卷标:38(1) 页码:96-97]

    120-92-3 = 931-94-2
    反应条件:1.1 Reagents: Sodium Borohydride Catalysts: Tungstate(6-),[μ12-[orthosilicato(4-)-Ko:Ko:Ko:Ko′:Ko′:Ko′:Ko′′:Ko′′:Ko′′:Ko′′′...
    标题:Catalysis By Heteropoly Acids: Some New Aspects
    作者:Joshi,M. V.; Narasimhan,C. S.
    参考文献:Journal Of Catalysis 日期:1989 卷标:120(1) 页码:282-6]

    120-92-3 + 1825-61-2 = 931-94-2 [标题:Reaction Conditions
    标题:Trialkylsilyl Triflates. Vi. A Facile Procedure For Acetalization Under Aprotic Conditions
    作者:Tsunoda,T.; Suzuki,M.; Noyori,R.
    参考文献:Tetrahedron Letters 日期:1980 卷标:21(14) 页码:1357-8]

    120-92-3 = 931-94-2
    反应条件:1.1 Reagents: Trimethyl Orthoformate Catalysts: Lithium Tetrafluoroborate Solvents: Methanol; 40 Min,Reflux1.2 Reagents: Sodium Bicarbonate Solvents: Water
    标题:An Efficient And Versatile Procedure For The Synthesis Of Acetals From Aldehydes And Ketones Catalyzed By Lithium Tetrafluoroborate
    作者:Hamada,Nao; Kazahaya,Kiyoshi; Shimizu,Hisashi; Sato,Tsuneo
    参考文献:Synlett 日期:2004 卷标:(6) 页码:1074-1076]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: (+/-)-Camphorsulfonic Acid; 1.5 H,Rt
    标题:A Versatile Method For The Protection Of Carbonyl Compounds By Camphor Sulfonic Acid
    作者:Yadav,Ram Naresh; Banik,Bimal Krishna
    参考文献:Current Organocatalysis 日期:2018 卷标:5(3) 页码:196-200]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: Sodium Sulfate Solvents: Methanol; 2 Min,Rt
    标题:Microwave Assisted Acetalization Of Carbonyl Compounds With Methanol Using Na2So4 (Anhydrous) And Mgso4 (Anhydrous) As Catalysts
    作者:Dewan,Sharwan K.; Singh,Ravinder
    参考文献:Oriental Journal Of Chemistry 日期:2002 卷标:18(3) 页码:521-524]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Monohydrate Solvents: Methanol; 30 Min,5 °C1.2 Reagents: Sodium Methoxide Solvents: Methanol; Neutralized
    标题:Process Development Of The Pde4 Inhibitor K-34
    作者:Yanagisawa,Arata; Taga,Masashi; Atsumi,Toshiyuki; Nishimura,Koichiro; Ando,Kyoji; Et Al
    参考文献:Organic Process Research & Development 日期:2011 卷标:15(2) 页码:376-381]

    120-92-3 = 931-94-2
    反应条件:1.1 Reagents: Triethyl Orthoformate Catalysts: Bromotrimethylsilane; 20 - 40 Min,Rt
    标题:Trimethylsilyl Bromide-Promoted Synthesis Of Acyclic And Cyclic Acetals
    作者:Wu,Liqiang; Yang,Chunguang; Yang,Limin; Yang,Lijuan
    参考文献:Youji Huaxue 日期:2009 卷标:29(11) 页码:1836-1839]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: Indium Triflate Solvents: Dichloromethane; 10 Min,Rt
    标题:Indium Triflate-Mediated Acetalization Of Aldehydes And Ketones
    作者:Smith,Brendan M.; Graham,Andrew E.
    参考文献:Tetrahedron Letters 日期:2006 卷标:47(52) 页码:9317-9319]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid,Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(Oh)2O10.Xh2O) Solvents: Methanol; 5 Min,Rt1.2 5 H,Rt
    标题:Simple Method For The Preparation Of Dimethyl Acetals From Ketones With Montmorillonite K 10 And P-Toluenesulfonic Acid
    作者:Regas,David
    参考文献:Synthetic Communications 日期:2006 卷标:36(15) 页码:2195-2201]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: Tetrafluoroboric Acid; 5 Min,25 - 30 °C
    标题:Tetrafluoroboric Acid Adsorbed On Silica Gel As A Reusable Heterogeneous Dual-Purpose Catalyst For Conversion Of Aldehydes/ketones Into Acetals/ketals And Back Again
    作者:Kumar,Dinesh; Kumar,Raj; Chakraborti,Asit K.
    参考文献:Synthesis 日期:2008 卷标:(8) 页码:1249-1256]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: Perchloric Acid,Silica; 5 Min,25 - 30 °C
    标题:Perchloric Acid Adsorbed On Silica Gel (HCLo4-Sio2) As An Inexpensive,Extremely Efficient,And Reusable Dual Catalyst System For Acetal/ketal Formation And Their Deprotection To Aldehydes/ketones
    作者:Kumar,Raj; Kumar,Dinesh; Chakraborti,Asit K.
    参考文献:Synthesis 日期:2007 卷标:(2) 页码:299-303]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Methanol; 24 H,Rt
    标题:Synthesis,17O Nmr Spectroscopy And Structure Of 2-Trifluoroacetyl-1-Methoxycycloalkenes
    作者:Bonacorso,Helio G.; Costa,Michelle B.; Moura,Sidnei; Pizzuti,Lucas; Martins,Marcos A. P.; Et Al
    参考文献:Journal Of Fluorine Chemistry 日期:2005 卷标:126(9-10) 页码:1396-1402]

    120-92-3 = 931-94-2
    反应条件:1.1 Reagents: Trimethyl Orthoformate Catalysts: Zinc Chloride Solvents: Methanol,Cyclohexane; 5 H,Reflux
    标题:Zinc Chloride As An Efficient Catalyst For Chemoselective Dimethyl Acetalization
    作者:Roy,Anupam; Rahman,Matiur; Das,Sudarshan; Kundu,Dhiman; Kundu,Shrishnu Kumar; Et Al
    参考文献:Synthetic Communications 日期:2009 卷标:39(4) 页码:590-595]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: Copper(Ii) Tetrafluoroborate; 5 Min,25 - 30 °C
    标题:Copper(Ii) Tetrafluoroborate As A Novel And Highly Efficient Catalyst For Acetal Formation
    作者:Kumar,Raj; Chakraborti,Asit K.
    参考文献:Tetrahedron Letters 日期:2005 卷标:46(48) 页码:8319-8323]

    120-92-3 = 931-94-2
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Methanol; 18 H,25 °C1.2 Reagents: Triethylamine
    标题:Photocatalytic Reductive Formation Of α-Tertiary Ethers From Ketals
    作者:Rossolini,Thomas; Ferko,Branislav; Dixon,Darren J.
    参考文献:Organic Letters 日期:2019 卷标:21(17) 页码:6668-6673
📜环戊酮置于n,N-Di-(2,6-Diisopropyl)-1,7-Dicyano-Perylen-3,4,9,10-Tetracarboxylic Acid Imide,三乙胺,Sodium Iodide体系中,用 乙腈 作为反应溶剂,化学反应 66.0H,反应生成 1,1-二甲氧基环戊烷
参考文献:不使用酸从醛和甲硅烷基醚光催化合成缩醛和缩酮
标题:不使用酸从醛和甲硅烷基醚光催化合成缩醛和缩酮
摘要:使用光而不是酸:从醛和酮衍生的甲硅烷基醚以及醛本身可以有效地反应,以非常好到极好的收率反应生成缩醛.醛类和醇类的底物范围很广,可以接受酸和氢不稳定的保护基团.
DOI:10.1002/chem.202203767

海关参考信息

专利信息


专利号:US-7368568-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-6933385-B2
优先权日:2001-08-03
标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:SCHERING AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-5386019-A
优先权日:1992-01-15
标 题 :Synthesis of inhibitors of calmodulin-mediated enzymes including KS-501, KS-502 and their enantiomers
发明人：DANISHEFSKY SAMUEL J; DUSHIN Russell; HAIT WILLIAM N
权利人:UNIV YALE
摘要:The total synthesis of a group of compounds with inhibitory effects on calmodulin-mediated enzyme activities has been accomplished. Among these synthesized compounds are KS-501 and KS-502. Other compounds that have been synthesized by the described scheme are ent-KS-501 and ent-KS-502 which are enantiomers of KS-501 and KS-502 and which also have inhibitory effects on calmodulin-mediated enzyme activities.

专利号:WO-0172706-A1
优先权日:2000-03-28
标题 :Synthesis of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
发明人：SAMBASIVAN GANESH; SRIDHARAN MADHAVAN; PADUDEVASTANA SATHYASHANKER; POORNAPRAJNA ACHARYA; MATHEW JOY; SRINATH SUMITHRA; NAIR SATHEESH
权利人:BIOCON LTD; SAMBASIVAN GANESH; SRIDHARAN MADHAVAN; PADUDEVASTANA SATHYASHANKER; POORNAPRAJNA ACHARYA; MATHEW JOY; SRINATH SUMITHRA; NAIR SATHEESH
摘要:The present invention discusses a novel process for the synthesis of [R-(R*,R*)]-2-(4-fluorophenyl)-B,D-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt by using 4-fluoro-α-[2-methyl-1-oxopropyl]η-oxo-N-β-diphenylbenzene butaneamide with (4R)-methyl 6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-3-acetate. The compound so prepared is useful as inhibitors of the enzyme HMG-CoA reductase and are thus used as hypolipidemic and hypocholesterolemic agents.

专利号:US-5280126-A
优先权日:1988-02-22
标题 :Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(±)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2-methyl-1-oxopropyl]-Y-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

专利号:US-5216174-A
优先权日:1988-02-22
标题:Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(±)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3carboxamide by a novel synthesis where 4-methyl-3-oxoN-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1Hpyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

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摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 420.
摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 389.
摘要:Fowler, L. S.; Sutherland, A., Science of Synthesis Knowledge Updates, (2010) 3, 129.
摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 408.
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