CAS: 89991-52-6; 1-Amino-5,8-Dihydroxy-4-((2-((2-Hydroxyethyl)Amino)Ethyl)Amino)Anthracene-9,10-Dione

该化合物是基于炭疽杆菌的乳胶化物剂二氧化丙酮的衍生物.该化合物是药物质量控制中一个重要的杂质参考标准,确保二氧化丙酮配方的纯度和安全.其特征完善的结构有利于药物研制和制造过程中精确的分析检测和量化.作为一个杂质标记,它有助于遵守管制准则,例如ICH Q3A/B, 有助于准确识别和控制与工艺有关的杂质.该化合物的稳定性和界定的化学特性使它成为药物分析的方法验证和批次一致性评估的可靠工具.

英文名称1-Amino-5,8-Dihydroxy-4-((2-((2-Hydroxyethyl)Amino)Ethyl)Amino)Anthracene-9,10-Dione
中文名称去[2-[(2-羟基乙基)氨基]乙基]米托蒽醌
IUPAC名称1-amino-5,8-dihydroxy-4-((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione
其它别名1-Amino-5,8-Dihydroxy-4-[[2-[(2-Hydroxyethyl)Amino]Ethyl]Amino]-9,10-Anthracenedione; Des[2-[(2-Hydroxyethyl)Amino]Ethyl] Mitoxantrone(Mitoxantrone Impurity A); 1-Amino-5,8-Dihydroxy-4-(2-(2-Hydroxyethylamino)Ethylamino)Anthracene-9,10-Dione; Des[2-[(2-Hydroxyethyl)Amino]Ethyl] Mitoxantrone\n(Mitoxantrone Impurity A); Mitoxantrone Impurity 1(Mitoxantrone Ep Impurity A); Des[2-[(2-Hydroxyethyl)Amino]Ethyl] Mitoxantrone; Mitoxantrone Ep Impurity A; 9,10-Anthracenedione, 1-Amino-5,8-Dihydroxy-4-[[2-[(2-Hydroxyethyl)Amino]Ethyl]Amino]-
CAS编号89991-52-6
MFCD编号:MFCD28009475
FDA UNII编号:BV89R7E6Y3
分子式:C18H19N3O5分子量:357.37
产品CID: 1930296
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: NBSLQRRHRCDIHJ-UHFFFAOYSA-N
InChI=1S/C18H19N3O5/c19-9-1-2-10(21-6-5-20-7-8-22)14-13(9)17(25)15-11(23)3-4-12(24)16(15)18(14)26/h1-4,20-24H,5-8,19H2
计算化学: 氢键受体数8.0氢键供体数6.0可旋转键数6.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338

上下游产品

1-fluoro-5,8-dihydroxy-4-((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione

合成工艺路线路线简述

1195810-93-5 = 89991-52-6
反应条件:1.1 Reagents: Ammonium Hydroxide Solvents: Pyridine,Water; 2 H,110 °C
标题:Mitoxantrone Analogues As Ligands For A Stem-Loop Structure Of Tau Pre-Mrna
作者:Liu,Yang; Peacey,Eleanor; Dickson,John; Donahue,Christine P.; Zheng,Suxin; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(21) 页码:6523-6526

📜1-氟-1-去[2-[(2-羟基乙基)氨基]乙基氨基]米托蒽醌置于ammonium Hydroxide体系中,用吡啶作为反应溶剂,化学反应 2.0H,以50%的收率获得产物去[2-[(2-羟基乙基)氨基]乙基]米托蒽醌
参考文献:Mitoxantrone Analogues As Ligands For A Stem−loop Structure Of Tau Pre-Mrna
标题:Mitoxantrone Analogues As Ligands For A Stem−loop Structure Of Tau Pre-Mrna
摘要:A Series Of Mitoxantrone (Mtx) Analogues Have Been Designed,Synthesized,And Evaluated For Binding To And Stabilizing A Stern-Loop Structure That Serves As A Splicing Regulatory Element In The Pre-Mrna Of Tau,Which Is Involved In Alzheimer'S And Other Neurodegenerative Diseases. Several Compounds Showed Significantly Improved Binding Activity Relative To The Original Screening Hit Mitoxantrone. These Findings Establish Essential Structure-Activity Relationships To Further Optimize The Activity Of This Promising Class Of Compounds.
DOI:10.1021/jm9013407