CAS: 6961-46-2; N-(2-Hydroxyethyl)-3-Phenylacrylamide

上下游产品

ethanolamine Cinnamic acid 3-phenyl-propenal cinnamoyl chloride5-Benzoyl-3-indancarbonsaeure-2'-zimtsaeureamidoethylester

肉桂酸置于三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,反应生成 羟乙桂胺
参考文献:Synthesis And Antidepressant-Like Action Of N-(2-Hydroxyethyl) Cinnamamide Derivatives In Mice
标题:Synthesis And Antidepressant-Like Action Of N-(2-Hydroxyethyl) Cinnamamide Derivatives In Mice
摘要:This Study Described The Chemical Synthesis And Pharmacological Evaluation Of A Series Of N-(2-Hydroxyethyl) Cinnamamide Derivatives. The Structures Of Them Were Characterized By Ir,(1)H-NMR,Ms And Elemental Analysis. Their Antidepressant Activities Were Evaluated By The Forced Swimming Test (Fst) And Tail Suspension Test (Tst). Pharmacological Results Of These Compounds Showed That Some Of Them,Given Orally,Significantly Reduced The Immobility Time In The Fst And Tst,Indicating The Antidepressant-Like Action. Among Them,Compounds N-(2-Hydroxyethyl)Cinnamamide (1G),(E)-3-(4-Hydroxy-3-Methoxyphenyl)-N-(2-Hydroxyethyl)Acrylamide (1I) And (E)-N-(2-Hydroxyethyl)-3-(3-Hydroxyphenyl)Acrylamide (1N),Active In The Two Models,Were Considered As The Most Promising Compounds In This Study.
DOI:10.1007/s00044-010-9470-7