CAS: 6279-86-3; Triethyl Methanetricarboxylate

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4704-94-3 80370-42-9 99116-11-7

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CAS号541-41-3 氯甲酸乙酯 | CAS号105-53-3 丙二酸二乙酯 | CAS号543-27-1 氯甲酸异丁酯 | CAS号141-78-6 乙酸乙酯 | CAS号105-58-8 碳酸二乙酯 | CAS号996-82-7 sodium 1,3-diet... | CAS号4755-77-5 草酰氯单乙酯 | CAS号4704-94-3 2-羟甲基-1,3-丙二醇 | CAS号51-79-6 氨基甲酸乙酯 | CAS号108-13-4 丙二酰胺 | CAS号141-82-2 丙二酸 | CAS号71170-82-6 3-溴丙烷-1,1,1-三羧酸三乙酯 | CAS号68922-87-2 三乙基甲三羧酸钠衍生物 | CAS号10174-66-0 Propanediamide,... | CAS号1087-97-4 苯甲酰丙二酸二乙酯 | CAS号65-85-0 苯甲酸 | CAS号505-52-2 十三碳二元酸

Triethyl Pent-4-Ene-1,2,2-Tricarboxylate置于titanium(Iv) Isopropylate,异丙基氯化镁体系中,用 乙醚 作为反应溶剂,化学反应 1.0H,以83%的收率获得产物甲烷三羧酸三乙酯
参考文献:通过有机钛中间体对酯基进行新型 [1,N]-碳到碳重排,其中 Nv 从 2 到 5.主要导致重排的全范围和局限性
标题:通过有机钛中间体对酯基进行新型 [1,N]-碳到碳重排,其中 Nv 从 2 到 5.主要导致重排的全范围和局限性
摘要:具有不饱和侧链如 2,12,20,22,24,31 或 37 的丙二酸酯和甲三羧酸酯在 (η2-丙烯)Ti(Oi-Pr)2 的促进下进行新的酯重排反应,得到琥珀酸酯衍生物 4或 α,β-不饱和酯 17,21,23,25,34 或 38,通过酯基团从其原始双-或三-酯位置迁移到乙炔-或烯烃-钛络合物.已经发现与所需迁移竞争的副反应是酯侧链的脱烷基化和简单的环化.确定了允许酯迁移优先路径的底物和条件以及该反应的范围和限制.
DOI:10.1246/bcsj.71.1673

专利信息

专利号:WO-2018108954-A1
优先权日:2016-12-12
标题 :Process for the preparation of 2-(3-(fluoromethyl)azetidin-1-yl)ethan-1-ol
发明人：GOSSELIN FRANCIS; LINGHU XIN
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Methods of making 2-(3-(fluoromethyl)azetidin-1-yl)ethan-1-ol 9, an intermediate useful for the synthesis of estrogen receptor modulating compounds are described.

专利号:US-9896479-B2
优先权日:2012-05-16
标 题 :Functionalized naphthalene fluorophores
发明人：BRUMMOND KAY M; KOCSIS LAURA S; BENEDETTI ERICA
权利人:BRUMMOND KAY M; KAY M BRUMMOND
摘要:Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted.

专利号:US-9512174-B2
优先权日:2012-05-16
标 题 :Synthesis, structure and use of functionalized naphthalenes

专利号:US-9260449-B2
优先权日:2009-05-21
标 题:Method for preparing D-biotin
发明人：PAN YAJIN; PI SHIQING; DING WENZHEN; GU LIXIN; WEI ANGFENG; HE YIMIN
权利人:ZHEJIANG MED XINCHANG PHARM
摘要:The invention discloses a D-biotin preparation method. In the prior art, with a synthesis method utilizing malonic acid diester as raw materials, impurities are also produced along with the obtained D-biotin. The D-biotin preparation method is characterized in that with the presence of dimethyl sulfoxide and inorganic base as catalysts, methane tricarboxylic acid trialkyl ester and (3aR, 8aS, 8bS)-1,3-dibenzyl-2-oxo-10H-iminazole [3,4-d] thiophene [1,2-a] sulfuryl halide are subjected to condensation reaction in methylbenzene solvent to obtain intermediate (3 aS,4S,6aR)-1,3-dibenzyl-4-(ω,ω,ω-3-methoxycarbonylbutyl)-4H-1H-thiophene[3,4-d]iminazol e-2,4(1H)-ketone, and the D-biotin is obtained after the intermediate is treated by the aftertreatment method. By the D-biotin preparation method, production of the impurities is avoided, quality of the biotin is greatly improved on the existing basis, and side reaction is avoided too.

专利号:US-2015344450-A1
优先权日:2012-05-16
标 题 :Synthesis, structure and use of functionalized naphthalenes

专利号:US-2013310558-A1
优先权日:2012-05-16
标 题 :Synthesis, structure and use of functionalized naphthalenes