CAS: 577778-58-6; 4-(3-(Pyridin-4-yl)-1H-1,2,4-Triazol-5-yl)Picolinonitrile

相似化合物

4329-78-6 38634-05-8 577778-58-6

上下游产品

1-Hydroxy-4-(5-Pyridin-4-Yl-1,2,4-Triazol-3-Ylidene)Pyridine 36770-53-3
1-Hydroxy-4-(5-Pyridin-4-Yl-1,2,4-Triazol-3-Ylidene)Pyridine 36770-53-3
托匹司他中间体3 N-Benzyloxymethyl-5-(2-Cyano-Pyridin-4-yl)-3-(Pyridin-4-yl)-1,2,4-Triazole 837371-70-7

异烟酸甲酯置于磷酸,双氧水,Sodium Methylate,一水合肼,二甲氨基甲酰氯体系中,用 甲醇,水,溶剂黄146,N,N-二甲基甲酰胺,正丁醇 作为反应溶剂,化学反应 17.5H,反应生成 托比司他
参考文献:一种托吡司他的合成方法
标题:一种托吡司他的合成方法
摘要:本发明提供了一种托吡司他i的合成方法,包括以下步骤:1),以异烟酸甲酯ii为原料,在氧化剂存在下,经氧化反应生成异烟酸甲酯n‑氧化物iii;2),再与水合肼缩合得到异烟肼n‑氧化物iv;3),化合物iv与4‑氰基吡啶v在醇碱条件下反应反应生成4‑(2‑(亚氨基(吡啶‑4‑基)甲基)肼羰基)吡啶n‑氧化物vi;4),在二甲氨基甲酰氯存在下,与氰化物反应反应生成2‑氰基‑n'‑(亚氨基(吡啶‑4‑基)甲基)异烟肼vii;5),所得化合物vii在酸存在下进行环合,得到托吡司他i;反应路线如下:本发明方法中,一方面总收率相对于文献收率大幅提高,另一方面,路线采用的原料简单易得且成本低廉,各步骤反应条件温和,后处理简单;非常易于工业化控制.

专利信息

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-10308615-B2
优先权日:2015-05-29
标 题:Heterocyclic compounds as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; CONDON JEFFREY SCOTT; FLICK ANDREW CHRISTOPHER; GOPALSAMY ARIAMALA; KIRINCICH STEVEN J; MATHIAS JOHN PAUL; STROBACH JOSEPH WALTER; XIANG JASON SHAOYUN; XING LI HUANG; WANG XIAOLUN
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2018230127-A1
优先权日:2015-08-13
标题 :Bicyclic-Fused Heteroaryl Or Aryl Compounds
发明人：ANDERSON DAVID RANDOLPH; CURRAN KEVIN JOSEPH; GAVRIN LORI KRIM; GOLDBERG JOEL ADAM; LEE ARTHUR; LOWE MICHAEL DENNIS; PATNY AKSHAY; PIERCE BETSY SUSAN; SAIAH EDDINE; TRZUPEK JOHN DAVID
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds of Formula (Ia) are disclosed which are inhibitors of Interleukin-1 receptor associated kinase (IRAK4). Methods of treatment, methods of synthesis, and intermediates are also disclosed as defined in the specification.

专利号:US-10316018-B2
优先权日:2015-08-27
标题 :Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators
发明人：LEE KATHERINE LIN; ALLAIS CHRISTOPHE PHILIPPE; DEHNHARDT CHRISTOPH MARTIN; GAVRIN LORI KRIM; HAN SEUNGIL; HEPWORTH DAVID; LEE ARTHUR; LOVERING FRANK ELDRIDGE; MATHIAS JOHN PAUL; OWEN DAFYDD RHYS; PAPAIOANNOU NIKOLAOS; SAIAH EDDINE; STROHBACH JOSEPH WALTER; TRZUPEK JOHN DAVID; WRIGHT STEPHEN WAYNE; ZAPF CHRISTOPH WOLFGANG
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-114773262-B
优先权日:2022-05-19
标题:Synthesis method of methyl 2-cyano-4-pyridinecarboxylate

专利号:US-2021290651-A1
优先权日:2020-03-20
标 题:Methods of treating viral infections using inhibitors of nucleotide synthesis pathways