CAS: 52670-38-9; 2-Ethynylaniline

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CAS号103529-16-4 (2-氨基苯炔基)三甲基硅烷 | CAS号615-43-0 2-碘苯胺 | CAS号74-86-2 乙炔 | CAS号1066-54-2 三甲基硅基乙炔 | CAS号167558-54-5 2-(2,2-dibromoe... | CAS号16433-96-8 2-硝基苯乙炔 | CAS号112671-40-6 N-[2-(2-trimeth... | CAS号112671-41-7 N-(2-(2-(trimet... | CAS号143321-89-5 Acetamide, 2,2,... | CAS号551-93-9 邻氨基苯乙酮 | CAS号120-72-9 吲哚 | CAS号3867-18-3 2-乙烯基苯胺 | CAS号32566-01-1 2-(2-氨基苯基)吲哚 | CAS号4491-33-2 2-喹啉甲酸乙酯 | CAS号228575-98-2 N-[2-[2-(2-amin... | CAS号948-65-2 2-苯基吲哚 | CAS号18735-98-3 5,11-dihydro-6H... | CAS号1885-29-6 2-氨基苯甲腈

📜2-Nitrocinnamic Acid置于palladium 10% On Activated Carbon,溴,一水合肼,溶剂黄146,1,8-二氮杂双环[5.4.0]十一碳-7-烯,三乙胺体系中,用 乙醇,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.2H,反应生成 2-氨基苯乙炔
参考文献:设计,合成和生物学评估带有1,2,3-三唑部分的新型尿嘧啶衍生物作为胸苷酸合酶(ts)抑制剂和潜在的抗肿瘤药物
标题:设计,合成和生物学评估带有1,2,3-三唑部分的新型尿嘧啶衍生物作为胸苷酸合酶(ts)抑制剂和潜在的抗肿瘤药物
摘要:胸苷酸合酶抑制剂的研究一直是抗癌药物开发的热点.在此,根据两种ts抑制剂的结构和药理特性,通过药物设计的分子组装原理,我们设计合成了30种新颖的尿嘧啶衍生物作为ts抑制剂.通过mtt分析评估了这些化合物对四种癌细胞系(a549,Ovcar-3,Sgc-7901和hepg2)的抗增殖能力.它们中的大多数对所有测试的细胞系均表现出优异的活性.此外,Hts分析结果表明,这些化合物具有独特的体外抑制hts活性的能力.值得注意的是,化合物13J对a549细胞表现出最强的活性(ic 50 = 1.18μm)和极显着的酶抑制(ic 50 = 0.13μm),优于培美曲塞(ptx,Ic 50 = 3.29μm和ic 50 = 2.04μm).流式细胞仪分析表明,化合物13J可以通过将细胞周期阻滞在g1 / S期来抑制a549细胞的增殖,进而诱导细胞凋亡.进一步的蛋白质印迹分析表明化合物13J可能下调周期检查点蛋白cyclin
DOI:10.1016/j.Ejmech.2019.03.047

专利信息

专利号:US-7342119-B2
优先权日:2003-09-30
标题 :Process for the synthesis of a CPLA2 inhibitor
发明人：DEHNHARDT CHRISTOPH M; MEGATI SREENIVASULU; MICHALAK RONALD S; RAVEENDRANATH PANOLIL
权利人:WYETH CORP
摘要:A process for making a substituted indole compound, including the steps of: reacting the compounds n nin a non-protic polar solvent in the presence of a catalyst to form the intermediate compoundn n nwherein Ph and X are as defined herein; and then,n nheating this intermediate compound in the solvent in the presence of the catalyst to form the substituted indole compoundn n nThe invention also includes compounds formed by this process.

专利号:WO-2024159724-A1
优先权日:2023-02-03
标 题:O-biphenyl oxazoline compound and synthesis method therefor
发明人：ZHU JIANSHE; WANG MINGCHUN; LI QINGYI
权利人:KEYLAB JIANGSU TECH CO LTD
摘要:A synthesis method for an o-biphenyl oxazoline compound. An aryl metal compound as represent by formula II reacts with aryl oxazoline as represented by formula III to generate the o-biphenyl oxazoline compound as represented by formula I. The o-biphenyl oxazoline compound can be used for industrial preparation of o-aminobiphenyl compounds, and used for synthesizing succinate dehydrogenase inhibitor fungicides (IV) such as fluxapyroxad, bixafen, boscalid, and pyraziflumid.

专利号:WO-2017118690-A1
优先权日:2016-01-08
标题:A novel synthetic pathway towards solithromycin and purification thereof
发明人：CUSAK ANJA; MARAS NENAD
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to an efficient route of synthesis of solithromycin and to a method of its purification which obviates the necessity of chromatographic purifications and improves the quality of the product by efficiently removing impurities.

专利号:US-2007066833-A1
优先权日:2005-08-19
标题 :Methods to synthesize indoles as precursors for pharmaceuticals
发明人：DUGAR SUNDEEP; GIANNOUSIS PETER
权利人:SCIOS INC
摘要:The invention provides improved methods for the synthesis of indoles, especially useful for making indoles having an ester or amide group at C-5. The methods involve cyclization of a protected ortho-acetylene-substituted aniline derivative to produce an indole.

专利号:US-2008177085-A1
优先权日:2003-09-30
标 题:Process for the Synthesis of a CPLA2 Inhibitor

专利号:US-2005070723-A1
优先权日:2003-09-30
标 题 :Process for the synthesis of a CPLA2 inhibitor