CAS: 4774-24-7; 2-(Piperazin-1-yl)Quinoline

该化合物是一种化学化合物,被归类为一种管状衍生物,主要以其作为血清素受体对立体者的作用而著称,它具有5-HT2血清受体子型的亲近性,有助于其药理效应.Quipazine已就其在...

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CAS号110-85-0 哌嗪 | CAS号612-62-4 2-氯喹啉 | CAS号112036-71-2 2-(4-Cyano-1-pi... | CAS号103-84-4 N-乙酰苯胺 | CAS号59-31-4 2-羟基喹啉 | CAS号139477-46-6 2-(3-(4-(2-quin...

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    4-(喹啉-2-基)哌嗪-1-羧酸叔丁酯置于三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 喹哌嗪
    参考文献:Discovery Of Imidazole Carboxamides As Potent And Selective Cck1R Agonists
    标题:Discovery Of Imidazole Carboxamides As Potent And Selective Cck1R Agonists
    摘要:High-Throughput Screening Revealed Diaryl Pyrazole 3 As A Selective Albeit Modest Cholecystokinin 1 Receptor (Cck1R) Agonist. Sar Studies Led To The Discovery And Optimization Of A Novel Class Of 1,2-Diaryl Imidazole Carboxamides. Compound 44,Which Was Pro. Led Extensively,Showed Good In Vivo Mouse Gallbladder Emptying (Mgbe) And Lean Mouse Overnight Food Intake (Onfi) Reduction Activities. (C) 2008 Elsevier Ltd. All Rights Reserved.
    DOI:10.1016/j.Bmcl.2008.06.057

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    专利信息


    专利号:CN-103596927-A
    优先权日:2011-06-06
    标 题:A new method for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline

    专利号:CN-102898428-B
    优先权日:2012-09-20
    标 题:A kind of microwave synthesis method of spirocyclic piperazine quaternary ammonium salt compound

    专利号:US-8076315-B2
    优先权日:2005-10-14
    标题:Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists
    发明人:CARLEY DAVID W; RADULOVACKI MIODRAG
    权利人:CARLEY DAVID W; RADULOVACKI MIODRAG; UNIV ILLINOIS
    摘要:This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need thereof an effective dose of one or a combination of prostanoid receptor antagonists (eg. ramatroban, ifetroban, diphloretin, phosphate, polyphloretin phosphate, seratrodast, SC19220). The prostanoid receptor antagonist or combination of prostanoid receptor antagonists can be administered in conjunction with one or more serotonin receptor agonists, one or more cannabinoids receptor agonists, one or more serotonin reuptake inhibitors, one or more noradrenalin reuptake inhibitors, a combination of reuptake inhibitors, an inhibitor of prostanoid synthesis, or any combination of the foregoing.

    专利号:CN-102898428-A
    优先权日:2012-09-20
    标 题:A kind of microwave synthesis method of spirocyclic piperazine quaternary ammonium salt compound
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    主要参考文献


    1: Mok E, Paquette M, Thibault L. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25. doi: 10.1006/appe.2000.0321. 804(2):206-11. doi: 10.1016/s0006-8993(98)00625-8. 779(1-2):84-95. doi: 10.1016/s0006-8993(97)01082-2. 80(2):559-66. doi: 10.1016/s0306-4522(96)00708-7. 61(3):645-53. doi: 10.1016/0306-4522(94)90441-3. 14(6):330-3. doi: 10.1055/s-2007-1021187. 74(6):3006-12. doi: 10.1152/jappl.1993.74.6.3006. 42(4):809-13. doi: 10.1016/0091-3057(92)90034-d. 256(3):973-82. 43(5):530-6. Russian.

    合成参考文献


    参考文献:10.1093/brain/awr167
    摘要:Filli L, Zörner B, Weinmann O, Schwab ME. Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome. Brain. 2011 Aug;134(Pt 8):2261–73. doi: 10.1093/brain/awr167.
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